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Quantitation of carboxyhaemoglobin in blood: external quality assessment of techniques.
Br J Biomed Sci. 1998 Jun; 55(2):123-6.BJ

Abstract

The performance of four dedicated carbon monoxide (CO)-oximeters (AVL, Chiron, IL, Radiometer), spectrophotometry with and without dithionite, spectrophotometry by second derivative, and the Whitehead and Worthington precipitation technique for the measurement of carboxyhaemoglobin in blood was compared by a mean of 136 participants in the United Kingdom National External Quality Assessment Scheme in 21 samples formulated to contain from 4% to 48% carboxyhaemoglobin. The dedicated instruments and spectrophotometry by second derivative were of significantly higher precision than the other techniques, producing fewer measurements rejected as being > 3 standard deviations from the sample mean and having a lower standard deviation for non-rejected measurements. The AVL instrument and spectrophotometry by second derivative had a significant positive bias compared to the other techniques. The Whitehead and Worthington method was of an unacceptably low precision.

Authors+Show Affiliations

Barnett K
Cardiff Bioanalytical Services Ltd, Cardiff Medicentre, Wales, UK.
Wilson JF
No affiliation info available

MeSH

Carbon Monoxide PoisoningCarboxyhemoglobinHumansOximetryQuality Assurance, Health CareSpectrophotometryWales

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10198470

Citation

Barnett, K, and J F. Wilson. "Quantitation of Carboxyhaemoglobin in Blood: External Quality Assessment of Techniques." British Journal of Biomedical Science, vol. 55, no. 2, 1998, pp. 123-6.
Barnett K, Wilson JF. Quantitation of carboxyhaemoglobin in blood: external quality assessment of techniques. Br J Biomed Sci. 1998;55(2):123-6.
Barnett, K., & Wilson, J. F. (1998). Quantitation of carboxyhaemoglobin in blood: external quality assessment of techniques. British Journal of Biomedical Science, 55(2), 123-6.
Barnett K, Wilson JF. Quantitation of Carboxyhaemoglobin in Blood: External Quality Assessment of Techniques. Br J Biomed Sci. 1998;55(2):123-6. PubMed PMID: 10198470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitation of carboxyhaemoglobin in blood: external quality assessment of techniques. AU - Barnett,K, AU - Wilson,J F, PY - 1999/4/13/pubmed PY - 1999/4/13/medline PY - 1999/4/13/entrez SP - 123 EP - 6 JF - British journal of biomedical science JO - Br J Biomed Sci VL - 55 IS - 2 N2 - The performance of four dedicated carbon monoxide (CO)-oximeters (AVL, Chiron, IL, Radiometer), spectrophotometry with and without dithionite, spectrophotometry by second derivative, and the Whitehead and Worthington precipitation technique for the measurement of carboxyhaemoglobin in blood was compared by a mean of 136 participants in the United Kingdom National External Quality Assessment Scheme in 21 samples formulated to contain from 4% to 48% carboxyhaemoglobin. The dedicated instruments and spectrophotometry by second derivative were of significantly higher precision than the other techniques, producing fewer measurements rejected as being > 3 standard deviations from the sample mean and having a lower standard deviation for non-rejected measurements. The AVL instrument and spectrophotometry by second derivative had a significant positive bias compared to the other techniques. The Whitehead and Worthington method was of an unacceptably low precision. SN - 0967-4845 UR - https://www.unboundmedicine.com/medline/citation/10198470/Quantitation_of_carboxyhaemoglobin_in_blood:_external_quality_assessment_of_techniques_ L2 - https://medlineplus.gov/carbonmonoxidepoisoning.html DB - PRIME DP - Unbound Medicine ER -