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A comparative study of recurrent pterygium surgery: limbal conjunctival autograft transplantation versus mitomycin C with conjunctival flap.
Ophthalmology. 1999 Apr; 106(4):817-21.O

Abstract

OBJECTIVE

To compare the recurrence rate following treatment of recurrent pterygia using one of two techniques-limbal conjunctival autograft transplantation versus low-dose intraoperative mitomycin C (0.2 mg/ml) combined with conjunctival flap closure.

DESIGN

Randomized clinical trial.

PARTICIPANTS

Eighty-one patients with recurrent pterygia treated by limbal conjunctival autograft transplantation (n= 41) or mitomycin C combined with conjunctival flap (n= 40) participated.

INTERVENTION

Limbal conjunctival autograft transplantation or low-dose intraoperative mitomycin C application with conjunctival flap technique was performed on recurrent pterygium cases.

MAIN OUTCOME MEASURES

Recurrence of pterygium and postoperative complications.

RESULTS

During mean follow-up periods of 16+/-1.9 and 15.5+/-1.5 months, six recurrences (14.6%) in the limbal conjunctival autograft transplantation group and five recurrences (12.5%) in the mitomycin C group were observed (P=0.77). The difference between the mean ages of recurrent (26.4+/-8.0 years) and nonrecurrent (35.8+/-11.9 years) cases for all patients was statistically significant (P=0.014). Technically, limbal conjunctival autograft transplantation seemed to be more difficult. The most frequent complication in limbal conjunctival autograft transplantation was graft edema, whereas that in the mitomycin C group was superficial keratitis.

CONCLUSION

Both techniques showed similar recurrence rates in the treatment of recurrent pterygia. Although technically easier to perform, further follow-up is necessary to determine the long-term safety of low-dose intraoperative mitomycin C with conjunctival flap closure. The surgeon's familiarity with either procedure should determine the method of choice.

Authors+Show Affiliations

Department of Ophthalmology, Gülhane Military Medical Academy, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10201608

Citation

Mutlu, F M., et al. "A Comparative Study of Recurrent Pterygium Surgery: Limbal Conjunctival Autograft Transplantation Versus Mitomycin C With Conjunctival Flap." Ophthalmology, vol. 106, no. 4, 1999, pp. 817-21.
Mutlu FM, Sobaci G, Tatar T, et al. A comparative study of recurrent pterygium surgery: limbal conjunctival autograft transplantation versus mitomycin C with conjunctival flap. Ophthalmology. 1999;106(4):817-21.
Mutlu, F. M., Sobaci, G., Tatar, T., & Yildirim, E. (1999). A comparative study of recurrent pterygium surgery: limbal conjunctival autograft transplantation versus mitomycin C with conjunctival flap. Ophthalmology, 106(4), 817-21.
Mutlu FM, et al. A Comparative Study of Recurrent Pterygium Surgery: Limbal Conjunctival Autograft Transplantation Versus Mitomycin C With Conjunctival Flap. Ophthalmology. 1999;106(4):817-21. PubMed PMID: 10201608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study of recurrent pterygium surgery: limbal conjunctival autograft transplantation versus mitomycin C with conjunctival flap. AU - Mutlu,F M, AU - Sobaci,G, AU - Tatar,T, AU - Yildirim,E, PY - 1999/4/14/pubmed PY - 1999/4/14/medline PY - 1999/4/14/entrez SP - 817 EP - 21 JF - Ophthalmology JO - Ophthalmology VL - 106 IS - 4 N2 - OBJECTIVE: To compare the recurrence rate following treatment of recurrent pterygia using one of two techniques-limbal conjunctival autograft transplantation versus low-dose intraoperative mitomycin C (0.2 mg/ml) combined with conjunctival flap closure. DESIGN: Randomized clinical trial. PARTICIPANTS: Eighty-one patients with recurrent pterygia treated by limbal conjunctival autograft transplantation (n= 41) or mitomycin C combined with conjunctival flap (n= 40) participated. INTERVENTION: Limbal conjunctival autograft transplantation or low-dose intraoperative mitomycin C application with conjunctival flap technique was performed on recurrent pterygium cases. MAIN OUTCOME MEASURES: Recurrence of pterygium and postoperative complications. RESULTS: During mean follow-up periods of 16+/-1.9 and 15.5+/-1.5 months, six recurrences (14.6%) in the limbal conjunctival autograft transplantation group and five recurrences (12.5%) in the mitomycin C group were observed (P=0.77). The difference between the mean ages of recurrent (26.4+/-8.0 years) and nonrecurrent (35.8+/-11.9 years) cases for all patients was statistically significant (P=0.014). Technically, limbal conjunctival autograft transplantation seemed to be more difficult. The most frequent complication in limbal conjunctival autograft transplantation was graft edema, whereas that in the mitomycin C group was superficial keratitis. CONCLUSION: Both techniques showed similar recurrence rates in the treatment of recurrent pterygia. Although technically easier to perform, further follow-up is necessary to determine the long-term safety of low-dose intraoperative mitomycin C with conjunctival flap closure. The surgeon's familiarity with either procedure should determine the method of choice. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/10201608/A_comparative_study_of_recurrent_pterygium_surgery:_limbal_conjunctival_autograft_transplantation_versus_mitomycin_C_with_conjunctival_flap_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(99)90172-0 DB - PRIME DP - Unbound Medicine ER -