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RETRACTED ARTICLE

Granisetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting after thyroidectomy.
Laryngoscope. 1999 04; 109(4):664-7.L

Abstract

OBJECTIVES/HYPOTHESIS

Patients undergoing thyroidectomy may be especially at risk of experiencing postoperative nausea and vomiting (PONV). This study was undertaken to compare the efficacy and safety of granisetron, droperidol, and metoclopramide for preventing PONV after thyroidectomy.

STUDY DESIGN

Prospective randomized, double-blind study.

METHODS

One hundred twenty female patients received granisetron 40 microg/kg, droperidol 20 microg/kg, or metoclopramide 0.2 mg/kg (n = 40, each) intravenously (IV) immediately before the induction of anesthesia. A standardized general anesthetic technique was employed throughout the procedure.

RESULTS

The incidence of a complete response, that is, no PONV and no need for another rescue antiemetic during the first 3 hours (0 to 3 hours) after anesthesia was 90% with granisetron, 55% with droperidol, and 50% with metoclopramide, respectively; the corresponding incidence during the next 21 hours (3 to 24 hours) after anesthesia was 85%, 50%, and 45% (P<.05; overall Fisher's Exact probability test). No clinically important adverse events were observed in any of the groups.

CONCLUSIONS

Prophylactic therapy with granisetron is superior to droperidol or metoclopramide for preventing PONV after thyroidectomy.

Authors+Show Affiliations

Department of Anesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

10201761

Citation

Fujii, Y, et al. "Granisetron, Droperidol, and Metoclopramide for Preventing Postoperative Nausea and Vomiting After Thyroidectomy." The Laryngoscope, vol. 109, no. 4, 1999, pp. 664-7.
Fujii Y, Tanaka H, Kobayashi N. Granisetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting after thyroidectomy. Laryngoscope. 1999;109(4):664-7.
Fujii, Y., Tanaka, H., & Kobayashi, N. (1999). Granisetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting after thyroidectomy. The Laryngoscope, 109(4), 664-7.
Fujii Y, Tanaka H, Kobayashi N. Granisetron, Droperidol, and Metoclopramide for Preventing Postoperative Nausea and Vomiting After Thyroidectomy. Laryngoscope. 1999;109(4):664-7. PubMed PMID: 10201761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Granisetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting after thyroidectomy. AU - Fujii,Y, AU - Tanaka,H, AU - Kobayashi,N, PY - 1999/4/14/pubmed PY - 1999/4/14/medline PY - 1999/4/14/entrez SP - 664 EP - 7 JF - The Laryngoscope JO - Laryngoscope VL - 109 IS - 4 N2 - OBJECTIVES/HYPOTHESIS: Patients undergoing thyroidectomy may be especially at risk of experiencing postoperative nausea and vomiting (PONV). This study was undertaken to compare the efficacy and safety of granisetron, droperidol, and metoclopramide for preventing PONV after thyroidectomy. STUDY DESIGN: Prospective randomized, double-blind study. METHODS: One hundred twenty female patients received granisetron 40 microg/kg, droperidol 20 microg/kg, or metoclopramide 0.2 mg/kg (n = 40, each) intravenously (IV) immediately before the induction of anesthesia. A standardized general anesthetic technique was employed throughout the procedure. RESULTS: The incidence of a complete response, that is, no PONV and no need for another rescue antiemetic during the first 3 hours (0 to 3 hours) after anesthesia was 90% with granisetron, 55% with droperidol, and 50% with metoclopramide, respectively; the corresponding incidence during the next 21 hours (3 to 24 hours) after anesthesia was 85%, 50%, and 45% (P<.05; overall Fisher's Exact probability test). No clinically important adverse events were observed in any of the groups. CONCLUSIONS: Prophylactic therapy with granisetron is superior to droperidol or metoclopramide for preventing PONV after thyroidectomy. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/10201761/Granisetron_droperidol_and_metoclopramide_for_preventing_postoperative_nausea_and_vomiting_after_thyroidectomy_ L2 - https://doi.org/10.1097/00005537-199904000-00028 DB - PRIME DP - Unbound Medicine ER -