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Long-term treatment with angiotensin converting enzyme inhibitor restores reduced calcitonin gene-related peptide-containing vasodilator nerve function in mesenteric artery of spontaneously hypertensive rats.
Jpn J Pharmacol. 1999 Feb; 79(2):221-9.JJ

Abstract

Effects of long-term treatment with angiotensin converting enzyme (ACE) inhibitor on decreased function of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRP nerves) in mesenteric resistance artery were investigated in spontaneously hypertensive rats (SHR). Eight-week-old SHR were treated for 7 weeks with 0.1% captopril, 0.01% temocapril, 0.05% pindolol or 0.005% hydralazine in drinking water. Long-term treatment with each drug significantly lowered mean blood pressure of SHR. In isolated and perfused mesenteric vascular beds with active tone, periarterial nerve stimulation (PNS) (0.5 to 8 Hz) produced frequency-dependent vasodilations, which were abolished by CGRP(8-37) (CGRP-receptor antagonist) and significantly smaller in SHR than in normotensive Wistar Kyoto rats. Treatment of SHR with captopril and temocapril but not with pindolol and hydralazine resulted in significantly greater PNS-induced vasodilation than in non-treated SHR, but ACE-inhibitor treatment did not affect vasodilation induced by exogenous CGRP. In captopril-treated SHR preparations, PNS evoked significantly larger CGRP-like immunoreactive release than in non-treated SHR. In non-treated 15-week-old SHR preparations, direct perfusion of captopril or temocapril (0.1 microM and 1 microM) did not modify frequency-dependent vasodilation in response to PNS. These results suggest that long-term ACE inhibitor treatment prevents or restores CGRP nerve function reduction in SHR.

Authors+Show Affiliations

Department of Clinical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Okayama University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10202858

Citation

Kawasaki, H, et al. "Long-term Treatment With Angiotensin Converting Enzyme Inhibitor Restores Reduced Calcitonin Gene-related Peptide-containing Vasodilator Nerve Function in Mesenteric Artery of Spontaneously Hypertensive Rats." Japanese Journal of Pharmacology, vol. 79, no. 2, 1999, pp. 221-9.
Kawasaki H, Okazaki M, Nakatsuma A, et al. Long-term treatment with angiotensin converting enzyme inhibitor restores reduced calcitonin gene-related peptide-containing vasodilator nerve function in mesenteric artery of spontaneously hypertensive rats. Jpn J Pharmacol. 1999;79(2):221-9.
Kawasaki, H., Okazaki, M., Nakatsuma, A., Mimaki, Y., Araki, H., & Gomita, Y. (1999). Long-term treatment with angiotensin converting enzyme inhibitor restores reduced calcitonin gene-related peptide-containing vasodilator nerve function in mesenteric artery of spontaneously hypertensive rats. Japanese Journal of Pharmacology, 79(2), 221-9.
Kawasaki H, et al. Long-term Treatment With Angiotensin Converting Enzyme Inhibitor Restores Reduced Calcitonin Gene-related Peptide-containing Vasodilator Nerve Function in Mesenteric Artery of Spontaneously Hypertensive Rats. Jpn J Pharmacol. 1999;79(2):221-9. PubMed PMID: 10202858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term treatment with angiotensin converting enzyme inhibitor restores reduced calcitonin gene-related peptide-containing vasodilator nerve function in mesenteric artery of spontaneously hypertensive rats. AU - Kawasaki,H, AU - Okazaki,M, AU - Nakatsuma,A, AU - Mimaki,Y, AU - Araki,H, AU - Gomita,Y, PY - 1999/4/15/pubmed PY - 1999/4/15/medline PY - 1999/4/15/entrez SP - 221 EP - 9 JF - Japanese journal of pharmacology JO - Jpn J Pharmacol VL - 79 IS - 2 N2 - Effects of long-term treatment with angiotensin converting enzyme (ACE) inhibitor on decreased function of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRP nerves) in mesenteric resistance artery were investigated in spontaneously hypertensive rats (SHR). Eight-week-old SHR were treated for 7 weeks with 0.1% captopril, 0.01% temocapril, 0.05% pindolol or 0.005% hydralazine in drinking water. Long-term treatment with each drug significantly lowered mean blood pressure of SHR. In isolated and perfused mesenteric vascular beds with active tone, periarterial nerve stimulation (PNS) (0.5 to 8 Hz) produced frequency-dependent vasodilations, which were abolished by CGRP(8-37) (CGRP-receptor antagonist) and significantly smaller in SHR than in normotensive Wistar Kyoto rats. Treatment of SHR with captopril and temocapril but not with pindolol and hydralazine resulted in significantly greater PNS-induced vasodilation than in non-treated SHR, but ACE-inhibitor treatment did not affect vasodilation induced by exogenous CGRP. In captopril-treated SHR preparations, PNS evoked significantly larger CGRP-like immunoreactive release than in non-treated SHR. In non-treated 15-week-old SHR preparations, direct perfusion of captopril or temocapril (0.1 microM and 1 microM) did not modify frequency-dependent vasodilation in response to PNS. These results suggest that long-term ACE inhibitor treatment prevents or restores CGRP nerve function reduction in SHR. SN - 0021-5198 UR - https://www.unboundmedicine.com/medline/citation/10202858/Long_term_treatment_with_angiotensin_converting_enzyme_inhibitor_restores_reduced_calcitonin_gene_related_peptide_containing_vasodilator_nerve_function_in_mesenteric_artery_of_spontaneously_hypertensive_rats_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/jjp/79.221?from=PubMed DB - PRIME DP - Unbound Medicine ER -