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Serodiagnosis of histoplasmosis, paracoccidioidomycosis and penicilliosis marneffei; current status and future trends.
Med Mycol. 1998 Dec; 36(6):351-64.MM

Abstract

Effective serodiagnosis of systemic fungal infections is of increasing importance, particularly with regard to the identification of infection with Histoplasma capsulatum, Paracoccidioides brasiliensis and Penicillium marneffei. Methodology has been based either around antibody or antigen detection, although there is clear overlap between the two. Antibody-based detection systems for the diagnosis of histoplasmosis, paracoccidioidomycosis and penicilliosis marneffei have now begun to incorporate a range of highly purified and well-characterized antigens, in contrast to the situation of a few years ago when relatively crude preparations derived from either whole cells or culture filtrate were used. The application of such antigens offers improvements in reproducibility and specificity, although the detection of meaningful antibody responses in immunosuppressed individuals remains a problem. Partly as a consequence of this a great deal of attention has focused on the development of antigen detection assays, and such methods have proved particularly successful, as for instance in the serodiagnosis of histoplasmosis in AIDS patients. The recent utilization of monoclonal antibodies in the development of antigen detection methods for the diagnosis of histoplasmosis and paracoccidioidomycosis offers further scope for improvement in this area.

Authors+Show Affiliations

Dunhill Dermatology Unit, St John's Institute of Dermatology, Guy's Hospital, London, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10206744

Citation

Hamilton, A J.. "Serodiagnosis of Histoplasmosis, Paracoccidioidomycosis and Penicilliosis Marneffei; Current Status and Future Trends." Medical Mycology, vol. 36, no. 6, 1998, pp. 351-64.
Hamilton AJ. Serodiagnosis of histoplasmosis, paracoccidioidomycosis and penicilliosis marneffei; current status and future trends. Med Mycol. 1998;36(6):351-64.
Hamilton, A. J. (1998). Serodiagnosis of histoplasmosis, paracoccidioidomycosis and penicilliosis marneffei; current status and future trends. Medical Mycology, 36(6), 351-64.
Hamilton AJ. Serodiagnosis of Histoplasmosis, Paracoccidioidomycosis and Penicilliosis Marneffei; Current Status and Future Trends. Med Mycol. 1998;36(6):351-64. PubMed PMID: 10206744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serodiagnosis of histoplasmosis, paracoccidioidomycosis and penicilliosis marneffei; current status and future trends. A1 - Hamilton,A J, PY - 1999/4/17/pubmed PY - 1999/4/17/medline PY - 1999/4/17/entrez SP - 351 EP - 64 JF - Medical mycology JO - Med Mycol VL - 36 IS - 6 N2 - Effective serodiagnosis of systemic fungal infections is of increasing importance, particularly with regard to the identification of infection with Histoplasma capsulatum, Paracoccidioides brasiliensis and Penicillium marneffei. Methodology has been based either around antibody or antigen detection, although there is clear overlap between the two. Antibody-based detection systems for the diagnosis of histoplasmosis, paracoccidioidomycosis and penicilliosis marneffei have now begun to incorporate a range of highly purified and well-characterized antigens, in contrast to the situation of a few years ago when relatively crude preparations derived from either whole cells or culture filtrate were used. The application of such antigens offers improvements in reproducibility and specificity, although the detection of meaningful antibody responses in immunosuppressed individuals remains a problem. Partly as a consequence of this a great deal of attention has focused on the development of antigen detection assays, and such methods have proved particularly successful, as for instance in the serodiagnosis of histoplasmosis in AIDS patients. The recent utilization of monoclonal antibodies in the development of antigen detection methods for the diagnosis of histoplasmosis and paracoccidioidomycosis offers further scope for improvement in this area. SN - 1369-3786 UR - https://www.unboundmedicine.com/medline/citation/10206744/Serodiagnosis_of_histoplasmosis_paracoccidioidomycosis_and_penicilliosis_marneffei L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1369-3786&date=1998&volume=36&issue=6&spage=351 DB - PRIME DP - Unbound Medicine ER -