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Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up.
Radiology. 1999 Mar; 210(3):799-805.R

Abstract

PURPOSE

To determine the rate and causes of false-negative findings and histologic underestimates at stereotactic biopsy of nonpalpable breast lesions.

MATERIALS AND METHODS

Stereotactic, 14-gauge, automated, large-core needle biopsy (LCNB) was performed in 483 consecutive nonpalpable breast lesions. Excision was advised for the 143 carcinomas, 25 atypical ductal hyperplasia (ADH) lesions, and five radial scars. Mammographic follow-up was advised for the benign lesions without a repeat biopsy.

RESULTS

Of the 310 benign lesions, 259 underwent mammographic follow-up at 6-85 months (median, 55 months) without repeat biopsy, 48 underwent repeat biopsy and three were lost to follow-up. On the basis of the histologic diagnosis of carcinoma at surgical biopsy, diagnosis with LCNB was not correct (i.e., disease was underestimated at histologic examination) in 14 (58%) of 24 ADH lesions and two (40%) of five radial scars. Two (1.2%) of 161 lesions with a final diagnosis of carcinoma were benign at LCNB but malignant at repeat biopsy (i.e., false-negative findings at LCNB). Repeat biopsy was prompted by mammographic progression at 6 and 18 months after LCNB.

CONCLUSION

The false-negative rate with LCNB was 1.2% in this study and 4.0% in the literature. The presence of carcinoma in ADH and radial scar lesions was often underestimated.

Authors+Show Affiliations

Department of Radiology, Palo Alto Medical Clinic, CA 94301, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10207484

Citation

Jackman, R J., et al. "Stereotactic, Automated, Large-core Needle Biopsy of Nonpalpable Breast Lesions: False-negative and Histologic Underestimation Rates After Long-term Follow-up." Radiology, vol. 210, no. 3, 1999, pp. 799-805.
Jackman RJ, Nowels KW, Rodriguez-Soto J, et al. Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up. Radiology. 1999;210(3):799-805.
Jackman, R. J., Nowels, K. W., Rodriguez-Soto, J., Marzoni, F. A., Finkelstein, S. I., & Shepard, M. J. (1999). Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up. Radiology, 210(3), 799-805.
Jackman RJ, et al. Stereotactic, Automated, Large-core Needle Biopsy of Nonpalpable Breast Lesions: False-negative and Histologic Underestimation Rates After Long-term Follow-up. Radiology. 1999;210(3):799-805. PubMed PMID: 10207484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stereotactic, automated, large-core needle biopsy of nonpalpable breast lesions: false-negative and histologic underestimation rates after long-term follow-up. AU - Jackman,R J, AU - Nowels,K W, AU - Rodriguez-Soto,J, AU - Marzoni,F A,Jr AU - Finkelstein,S I, AU - Shepard,M J, PY - 1999/4/20/pubmed PY - 2001/3/28/medline PY - 1999/4/20/entrez SP - 799 EP - 805 JF - Radiology JO - Radiology VL - 210 IS - 3 N2 - PURPOSE: To determine the rate and causes of false-negative findings and histologic underestimates at stereotactic biopsy of nonpalpable breast lesions. MATERIALS AND METHODS: Stereotactic, 14-gauge, automated, large-core needle biopsy (LCNB) was performed in 483 consecutive nonpalpable breast lesions. Excision was advised for the 143 carcinomas, 25 atypical ductal hyperplasia (ADH) lesions, and five radial scars. Mammographic follow-up was advised for the benign lesions without a repeat biopsy. RESULTS: Of the 310 benign lesions, 259 underwent mammographic follow-up at 6-85 months (median, 55 months) without repeat biopsy, 48 underwent repeat biopsy and three were lost to follow-up. On the basis of the histologic diagnosis of carcinoma at surgical biopsy, diagnosis with LCNB was not correct (i.e., disease was underestimated at histologic examination) in 14 (58%) of 24 ADH lesions and two (40%) of five radial scars. Two (1.2%) of 161 lesions with a final diagnosis of carcinoma were benign at LCNB but malignant at repeat biopsy (i.e., false-negative findings at LCNB). Repeat biopsy was prompted by mammographic progression at 6 and 18 months after LCNB. CONCLUSION: The false-negative rate with LCNB was 1.2% in this study and 4.0% in the literature. The presence of carcinoma in ADH and radial scar lesions was often underestimated. SN - 0033-8419 UR - https://www.unboundmedicine.com/medline/citation/10207484/Stereotactic_automated_large_core_needle_biopsy_of_nonpalpable_breast_lesions:_false_negative_and_histologic_underestimation_rates_after_long_term_follow_up_ L2 - https://pubs.rsna.org/doi/10.1148/radiology.210.3.r99mr19799?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -