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Diagnosis and management of gout.
Am Fam Physician. 1999 Apr 01; 59(7):1799-806, 1810.AF

Abstract

Gout is a disease resulting from the deposition of urate crystals caused by the overproduction or underexcretion of uric acid. The disease is often, but not always, associated with elevated serum uric acid levels. Clinical manifestations include acute and chronic arthritis, tophi, interstitial renal disease and uric acid nephrolithiasis. The diagnosis is based on the identification of uric acid crystals in joints, tissues or body fluids. Treatment goals include termination of the acute attack, prevention of recurrent attacks and prevention of complications associated with the deposition of urate crystals in tissues. Pharmacologic management remains the mainstay of treatment. Acute attacks may be terminated with the use of nonsteroidal anti-inflammatory agents, colchicine or intra-articular injections of corticosteroids. Probenecid, sulfinpyrazone and allopurinol can be used to prevent recurrent attacks. Obesity, alcohol intake and certain foods and medications can contribute to hyperuricemia. These potentially exacerbating factors should be identified and modified.

Authors+Show Affiliations

Department of Clinical Pharmacy Practice, University of Mississippi School of Pharmacy, University of Mississippi Medical Center, Jackson 39216, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10208700

Citation

Pittman, J R., and M H. Bross. "Diagnosis and Management of Gout." American Family Physician, vol. 59, no. 7, 1999, pp. 1799-806, 1810.
Pittman JR, Bross MH. Diagnosis and management of gout. Am Fam Physician. 1999;59(7):1799-806, 1810.
Pittman, J. R., & Bross, M. H. (1999). Diagnosis and management of gout. American Family Physician, 59(7), 1799-806, 1810.
Pittman JR, Bross MH. Diagnosis and Management of Gout. Am Fam Physician. 1999 Apr 1;59(7):1799-806, 1810. PubMed PMID: 10208700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and management of gout. AU - Pittman,J R, AU - Bross,M H, PY - 1999/4/20/pubmed PY - 1999/4/20/medline PY - 1999/4/20/entrez SP - 1799-806, 1810 JF - American family physician JO - Am Fam Physician VL - 59 IS - 7 N2 - Gout is a disease resulting from the deposition of urate crystals caused by the overproduction or underexcretion of uric acid. The disease is often, but not always, associated with elevated serum uric acid levels. Clinical manifestations include acute and chronic arthritis, tophi, interstitial renal disease and uric acid nephrolithiasis. The diagnosis is based on the identification of uric acid crystals in joints, tissues or body fluids. Treatment goals include termination of the acute attack, prevention of recurrent attacks and prevention of complications associated with the deposition of urate crystals in tissues. Pharmacologic management remains the mainstay of treatment. Acute attacks may be terminated with the use of nonsteroidal anti-inflammatory agents, colchicine or intra-articular injections of corticosteroids. Probenecid, sulfinpyrazone and allopurinol can be used to prevent recurrent attacks. Obesity, alcohol intake and certain foods and medications can contribute to hyperuricemia. These potentially exacerbating factors should be identified and modified. SN - 0002-838X UR - https://www.unboundmedicine.com/medline/citation/10208700/Diagnosis_and_management_of_gout_ L2 - https://www.aafp.org/link_out?pmid=10208700 DB - PRIME DP - Unbound Medicine ER -