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Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease.
QJM. 1999 Jan; 92(1):39-45.QJM

Abstract

We studied the plasma chain-breaking antioxidants alpha carotene, beta carotene, lycopene, Vitamin A, Vitamin C, Vitamin E and a measure of total antioxidant capacity, TAC, in 79 patients with Alzheimer's disease (AD), 37 patients with vascular dementia (VaD), 18 patients with Parkinson's disease and dementia (PDem), and 58 matching controls, together with 41 patients with Parkinson's disease (PD) and 41 matching controls. Significant reductions in individual antioxidants were observed in all dementia groups. When compared to controls, the following were reduced: Vitamin A in AD (p < 0.01) and VaD (p < 0.001); Vitamin C in AD (p < 0.001), VaD (p < 0.001) and PDem (p < 0.01); Vitamin E in AD (p < 0.01) and VaD (p < 0.001); beta carotene in VaD (p = 0.01); lycopene in PDem (p < 0.001). Lycopene was also reduced in PDem compared to AD (p < 0.001) and VaD (p < 0.001). Antioxidant levels in PD were not depleted. No significant change in TAC was seen in any group. The reduction in plasma chain-breaking antioxidants in patients with dementia may reflect an increased free-radical activity, and a common role in cognitive impairment in these conditions. Increased free-radical activity in VaD and PDem could be associated with concomitant AD pathology. Individual antioxidant changes are not reflected in TAC.

Authors+Show Affiliations

Department of Geriatric Medicine, Queen's University of Belfast, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10209671

Citation

Foy, C J., et al. "Plasma Chain-breaking Antioxidants in Alzheimer's Disease, Vascular Dementia and Parkinson's Disease." QJM : Monthly Journal of the Association of Physicians, vol. 92, no. 1, 1999, pp. 39-45.
Foy CJ, Passmore AP, Vahidassr MD, et al. Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease. QJM. 1999;92(1):39-45.
Foy, C. J., Passmore, A. P., Vahidassr, M. D., Young, I. S., & Lawson, J. T. (1999). Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease. QJM : Monthly Journal of the Association of Physicians, 92(1), 39-45.
Foy CJ, et al. Plasma Chain-breaking Antioxidants in Alzheimer's Disease, Vascular Dementia and Parkinson's Disease. QJM. 1999;92(1):39-45. PubMed PMID: 10209671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease. AU - Foy,C J, AU - Passmore,A P, AU - Vahidassr,M D, AU - Young,I S, AU - Lawson,J T, PY - 1999/4/21/pubmed PY - 1999/4/21/medline PY - 1999/4/21/entrez SP - 39 EP - 45 JF - QJM : monthly journal of the Association of Physicians JO - QJM VL - 92 IS - 1 N2 - We studied the plasma chain-breaking antioxidants alpha carotene, beta carotene, lycopene, Vitamin A, Vitamin C, Vitamin E and a measure of total antioxidant capacity, TAC, in 79 patients with Alzheimer's disease (AD), 37 patients with vascular dementia (VaD), 18 patients with Parkinson's disease and dementia (PDem), and 58 matching controls, together with 41 patients with Parkinson's disease (PD) and 41 matching controls. Significant reductions in individual antioxidants were observed in all dementia groups. When compared to controls, the following were reduced: Vitamin A in AD (p < 0.01) and VaD (p < 0.001); Vitamin C in AD (p < 0.001), VaD (p < 0.001) and PDem (p < 0.01); Vitamin E in AD (p < 0.01) and VaD (p < 0.001); beta carotene in VaD (p = 0.01); lycopene in PDem (p < 0.001). Lycopene was also reduced in PDem compared to AD (p < 0.001) and VaD (p < 0.001). Antioxidant levels in PD were not depleted. No significant change in TAC was seen in any group. The reduction in plasma chain-breaking antioxidants in patients with dementia may reflect an increased free-radical activity, and a common role in cognitive impairment in these conditions. Increased free-radical activity in VaD and PDem could be associated with concomitant AD pathology. Individual antioxidant changes are not reflected in TAC. SN - 1460-2725 UR - https://www.unboundmedicine.com/medline/citation/10209671/Plasma_chain_breaking_antioxidants_in_Alzheimer's_disease_vascular_dementia_and_Parkinson's_disease_ L2 - https://academic.oup.com/qjmed/article-lookup/doi/10.1093/qjmed/92.1.39 DB - PRIME DP - Unbound Medicine ER -