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Diet and risk of cancer of the upper aerodigestive tract--II. Nutrients.
Oral Oncol 1999; 35(1):22-6OO

Abstract

In order to examine the risks of cancer of the upper aerodigestive tract (UADC) associated with nutrient intake, a case-control study was conducted in Uruguay in the period of January 1996-December 1997. All patients afflicted with cancer of the oral cavity, pharynx, larynx, and esophagus, were included in the study. Cases were frequency-matched with hospitalized patients on age, sex, residence, and urban/rural status. A strong positive association with protein intake was observed (OR 2.5, 95% CI 1.5-4.4), whereas antioxidants were associated with an inverse association (OR for vitamin C 0.5, 95% CI 0.3-0.8). Non-nutritive substances, like flavonoids displayed a marked reduction in risk of 70%. Possible mechanisms for these findings are discussed.

Authors+Show Affiliations

Registro Nacional de Cancer, Montevideo Uruguay.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10211306

Citation

De Stefani, E, et al. "Diet and Risk of Cancer of the Upper Aerodigestive tract--II. Nutrients." Oral Oncology, vol. 35, no. 1, 1999, pp. 22-6.
De Stefani E, Ronco A, Mendilaharsu M, et al. Diet and risk of cancer of the upper aerodigestive tract--II. Nutrients. Oral Oncol. 1999;35(1):22-6.
De Stefani, E., Ronco, A., Mendilaharsu, M., & Deneo-Pellegrini, H. (1999). Diet and risk of cancer of the upper aerodigestive tract--II. Nutrients. Oral Oncology, 35(1), pp. 22-6.
De Stefani E, et al. Diet and Risk of Cancer of the Upper Aerodigestive tract--II. Nutrients. Oral Oncol. 1999;35(1):22-6. PubMed PMID: 10211306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and risk of cancer of the upper aerodigestive tract--II. Nutrients. AU - De Stefani,E, AU - Ronco,A, AU - Mendilaharsu,M, AU - Deneo-Pellegrini,H, PY - 1999/4/22/pubmed PY - 1999/4/22/medline PY - 1999/4/22/entrez SP - 22 EP - 6 JF - Oral oncology JO - Oral Oncol. VL - 35 IS - 1 N2 - In order to examine the risks of cancer of the upper aerodigestive tract (UADC) associated with nutrient intake, a case-control study was conducted in Uruguay in the period of January 1996-December 1997. All patients afflicted with cancer of the oral cavity, pharynx, larynx, and esophagus, were included in the study. Cases were frequency-matched with hospitalized patients on age, sex, residence, and urban/rural status. A strong positive association with protein intake was observed (OR 2.5, 95% CI 1.5-4.4), whereas antioxidants were associated with an inverse association (OR for vitamin C 0.5, 95% CI 0.3-0.8). Non-nutritive substances, like flavonoids displayed a marked reduction in risk of 70%. Possible mechanisms for these findings are discussed. SN - 1368-8375 UR - https://www.unboundmedicine.com/medline/citation/10211306/Diet_and_risk_of_cancer_of_the_upper_aerodigestive_tract__II__Nutrients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(98)00061-X DB - PRIME DP - Unbound Medicine ER -