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Effect of branched-chain amino acids (BCAA), glucose, and glucose plus BCAA on endurance performance in rats.
Med Sci Sports Exerc 1999; 31(4):583-7MS

Abstract

PURPOSE

The purpose of this study was to assess the effects of pre-exercise administration of branched-chain amino acids (BCAA), glucose, and glucose plus BCAA on time to exhaustion during treadmill exercise in rats.

METHODS

Wistar rats were injected intraperitoneally with 1 mL of saline (0.9% NaCl), BCAA (30 mg), glucose (100 mg), or glucose plus BCAA 5 min before either 45 min of submaximal exercise (N = 32) or running to exhaustion (N = 24). After the submaximal exercise test, blood was collected for the measurement of ammonia, BCAA, free tryptophan (free TRP), glucose, free fatty acid, and lactic acid, and muscle samples were taken from the m. soleus for determination of glycogen content.

RESULTS

Mean run time to exhaustion was significantly longer after BCAA administration (158+/-26 min) compared with that after saline (118+/-35 min)(P<0.05) but not compared with that after glucose administration (179+/-21 min). When glucose is administered before exercise, the supplementary administration of BCAA had no additional effect on performance (171+/-12 min). The data on blood ammonia, ratio of free TRP/BCAA, and muscle glycogen did not provide a clue for explaining the higher endurance performance after BCAA supplementation.

CONCLUSION

The results support the hypothesis that the effect of BCAA administration on performance could be related to carbohydrate availability during exercise.

Authors+Show Affiliations

Department of Pediatric Cardiology, and Institute of Kinesiology and Sport Sciences, University of Ghent, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10211856

Citation

Calders, P, et al. "Effect of Branched-chain Amino Acids (BCAA), Glucose, and Glucose Plus BCAA On Endurance Performance in Rats." Medicine and Science in Sports and Exercise, vol. 31, no. 4, 1999, pp. 583-7.
Calders P, Matthys D, Derave W, et al. Effect of branched-chain amino acids (BCAA), glucose, and glucose plus BCAA on endurance performance in rats. Med Sci Sports Exerc. 1999;31(4):583-7.
Calders, P., Matthys, D., Derave, W., & Pannier, J. L. (1999). Effect of branched-chain amino acids (BCAA), glucose, and glucose plus BCAA on endurance performance in rats. Medicine and Science in Sports and Exercise, 31(4), pp. 583-7.
Calders P, et al. Effect of Branched-chain Amino Acids (BCAA), Glucose, and Glucose Plus BCAA On Endurance Performance in Rats. Med Sci Sports Exerc. 1999;31(4):583-7. PubMed PMID: 10211856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of branched-chain amino acids (BCAA), glucose, and glucose plus BCAA on endurance performance in rats. AU - Calders,P, AU - Matthys,D, AU - Derave,W, AU - Pannier,J L, PY - 1999/4/22/pubmed PY - 1999/4/22/medline PY - 1999/4/22/entrez SP - 583 EP - 7 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 31 IS - 4 N2 - PURPOSE: The purpose of this study was to assess the effects of pre-exercise administration of branched-chain amino acids (BCAA), glucose, and glucose plus BCAA on time to exhaustion during treadmill exercise in rats. METHODS: Wistar rats were injected intraperitoneally with 1 mL of saline (0.9% NaCl), BCAA (30 mg), glucose (100 mg), or glucose plus BCAA 5 min before either 45 min of submaximal exercise (N = 32) or running to exhaustion (N = 24). After the submaximal exercise test, blood was collected for the measurement of ammonia, BCAA, free tryptophan (free TRP), glucose, free fatty acid, and lactic acid, and muscle samples were taken from the m. soleus for determination of glycogen content. RESULTS: Mean run time to exhaustion was significantly longer after BCAA administration (158+/-26 min) compared with that after saline (118+/-35 min)(P<0.05) but not compared with that after glucose administration (179+/-21 min). When glucose is administered before exercise, the supplementary administration of BCAA had no additional effect on performance (171+/-12 min). The data on blood ammonia, ratio of free TRP/BCAA, and muscle glycogen did not provide a clue for explaining the higher endurance performance after BCAA supplementation. CONCLUSION: The results support the hypothesis that the effect of BCAA administration on performance could be related to carbohydrate availability during exercise. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/10211856/Effect_of_branched_chain_amino_acids__BCAA__glucose_and_glucose_plus_BCAA_on_endurance_performance_in_rats_ L2 - http://Insights.ovid.com/pubmed?pmid=10211856 DB - PRIME DP - Unbound Medicine ER -