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Genetic models for non insulin dependent diabetes mellitus in rodents.
J Basic Clin Physiol Pharmacol 1998; 9(2-4):325-45JB

Abstract

Efforts to identify human genes with major effects on insulin resistance and type II diabetes have yet to be successful because of the technical difficulties associated with the analysis of complex traits in humans. Animal models, particularly the rodent models with their well developed genetic tools, and their genetic similarity to humans, offer an alternate approach to access genes important in the etiology of diabetes. This approach is validated by the remarkable progress that has been made in the identification and characterization of the genes mutated in five monogenic mouse models of obesity. Identification of these genes has led to new insights into the etiology of obesity and provided promising targets for therapeutic intervention. Arguably, genetic animal models could do the same for our understanding of diabetes. In this brief review, we introduce rodent models of type II diabetes and report on the state of their genetic analyses.

Authors+Show Affiliations

Jackson Laboratory, Bar Harbor, Maine 04609, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

10212842

Citation

Kim, J H., et al. "Genetic Models for Non Insulin Dependent Diabetes Mellitus in Rodents." Journal of Basic and Clinical Physiology and Pharmacology, vol. 9, no. 2-4, 1998, pp. 325-45.
Kim JH, Nishina PM, Naggert JK. Genetic models for non insulin dependent diabetes mellitus in rodents. J Basic Clin Physiol Pharmacol. 1998;9(2-4):325-45.
Kim, J. H., Nishina, P. M., & Naggert, J. K. (1998). Genetic models for non insulin dependent diabetes mellitus in rodents. Journal of Basic and Clinical Physiology and Pharmacology, 9(2-4), pp. 325-45.
Kim JH, Nishina PM, Naggert JK. Genetic Models for Non Insulin Dependent Diabetes Mellitus in Rodents. J Basic Clin Physiol Pharmacol. 1998;9(2-4):325-45. PubMed PMID: 10212842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic models for non insulin dependent diabetes mellitus in rodents. AU - Kim,J H, AU - Nishina,P M, AU - Naggert,J K, PY - 1999/4/23/pubmed PY - 1999/4/23/medline PY - 1999/4/23/entrez SP - 325 EP - 45 JF - Journal of basic and clinical physiology and pharmacology JO - J Basic Clin Physiol Pharmacol VL - 9 IS - 2-4 N2 - Efforts to identify human genes with major effects on insulin resistance and type II diabetes have yet to be successful because of the technical difficulties associated with the analysis of complex traits in humans. Animal models, particularly the rodent models with their well developed genetic tools, and their genetic similarity to humans, offer an alternate approach to access genes important in the etiology of diabetes. This approach is validated by the remarkable progress that has been made in the identification and characterization of the genes mutated in five monogenic mouse models of obesity. Identification of these genes has led to new insights into the etiology of obesity and provided promising targets for therapeutic intervention. Arguably, genetic animal models could do the same for our understanding of diabetes. In this brief review, we introduce rodent models of type II diabetes and report on the state of their genetic analyses. SN - 0792-6855 UR - https://www.unboundmedicine.com/medline/citation/10212842/Genetic_models_for_non_insulin_dependent_diabetes_mellitus_in_rodents_ L2 - https://www.degruyter.com/doi/10.1515/jbcpp.1998.9.2-4.325 DB - PRIME DP - Unbound Medicine ER -