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SPECT imaging of pre- and postsynaptic dopaminergic alterations in L-dopa-untreated PD.
Neurology. 1999 Apr 12; 52(6):1206-14.Neur

Abstract

BACKGROUND

In PD, presynaptic dopamine transporters are known to be decreased, whereas postsynaptic striatal D2 receptors are proposed to be upregulated. However, the relationship between these alterations is not clear.

OBJECTIVE

To evaluate the ability of SPECT to detect both the pre- and postsynaptic dopaminergic alterations of the striatum in patients with L-dopa-untreated PD.

METHODS

We studied 10 L-dopa-untreated patients with clinically mild PD and 21 age-matched normal controls. Individuals had both presynaptic [123I]beta-CIT dopamine transporter and postsynaptic [123I]IBF D2 SPECT studies 1 week apart.

RESULTS

In PD patients, the dopamine transporter binding potential Rv ipsilateral/contralateral to the most affected limbs was 30%/41%, 41%/50%, and 59%/68% lower than controls for caudate, anterior putamen, and posterior putamen, respectively. These bilateral Rv decreases showed a lateralized difference more reduced in the contralateral striatum as well as intrastriatal differences most reduced in the posterior putamen. In contrast, in PD patients the D2 binding potential Rv ipsilateral/contralateral was 15%/16% higher for caudate, 18%/14% higher for anterior putamen, and 28%/31% higher for posterior putamen. These bilateral Rv increases showed no lateralized differences and less marked intrastriatal differences. The motor Unified Parkinson's Disease Rating Scale scores negatively correlated with dopamine transporter Rv but not with D2 Rv.

CONCLUSIONS

SPECT imaging can detect characteristic dopaminergic alterations in the striatum of dopa-untreated PD patients including the upregulation of postsynaptic D2 receptors (denervation supersensitivity). SPECT is widely available and is a promising clinical tool to evaluate PD patients.

Authors+Show Affiliations

Division of Nuclear Medicine, Mount Sinai Hospital Site of University Medical Imaging Center, University of Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10214745

Citation

Ichise, M, et al. "SPECT Imaging of Pre- and Postsynaptic Dopaminergic Alterations in L-dopa-untreated PD." Neurology, vol. 52, no. 6, 1999, pp. 1206-14.
Ichise M, Kim YJ, Ballinger JR, et al. SPECT imaging of pre- and postsynaptic dopaminergic alterations in L-dopa-untreated PD. Neurology. 1999;52(6):1206-14.
Ichise, M., Kim, Y. J., Ballinger, J. R., Vines, D., Erami, S. S., Tanaka, F., & Lang, A. E. (1999). SPECT imaging of pre- and postsynaptic dopaminergic alterations in L-dopa-untreated PD. Neurology, 52(6), 1206-14.
Ichise M, et al. SPECT Imaging of Pre- and Postsynaptic Dopaminergic Alterations in L-dopa-untreated PD. Neurology. 1999 Apr 12;52(6):1206-14. PubMed PMID: 10214745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SPECT imaging of pre- and postsynaptic dopaminergic alterations in L-dopa-untreated PD. AU - Ichise,M, AU - Kim,Y J, AU - Ballinger,J R, AU - Vines,D, AU - Erami,S S, AU - Tanaka,F, AU - Lang,A E, PY - 1999/4/24/pubmed PY - 1999/4/24/medline PY - 1999/4/24/entrez SP - 1206 EP - 14 JF - Neurology JO - Neurology VL - 52 IS - 6 N2 - BACKGROUND: In PD, presynaptic dopamine transporters are known to be decreased, whereas postsynaptic striatal D2 receptors are proposed to be upregulated. However, the relationship between these alterations is not clear. OBJECTIVE: To evaluate the ability of SPECT to detect both the pre- and postsynaptic dopaminergic alterations of the striatum in patients with L-dopa-untreated PD. METHODS: We studied 10 L-dopa-untreated patients with clinically mild PD and 21 age-matched normal controls. Individuals had both presynaptic [123I]beta-CIT dopamine transporter and postsynaptic [123I]IBF D2 SPECT studies 1 week apart. RESULTS: In PD patients, the dopamine transporter binding potential Rv ipsilateral/contralateral to the most affected limbs was 30%/41%, 41%/50%, and 59%/68% lower than controls for caudate, anterior putamen, and posterior putamen, respectively. These bilateral Rv decreases showed a lateralized difference more reduced in the contralateral striatum as well as intrastriatal differences most reduced in the posterior putamen. In contrast, in PD patients the D2 binding potential Rv ipsilateral/contralateral was 15%/16% higher for caudate, 18%/14% higher for anterior putamen, and 28%/31% higher for posterior putamen. These bilateral Rv increases showed no lateralized differences and less marked intrastriatal differences. The motor Unified Parkinson's Disease Rating Scale scores negatively correlated with dopamine transporter Rv but not with D2 Rv. CONCLUSIONS: SPECT imaging can detect characteristic dopaminergic alterations in the striatum of dopa-untreated PD patients including the upregulation of postsynaptic D2 receptors (denervation supersensitivity). SPECT is widely available and is a promising clinical tool to evaluate PD patients. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/10214745/SPECT_imaging_of_pre__and_postsynaptic_dopaminergic_alterations_in_L_dopa_untreated_PD_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=10214745 DB - PRIME DP - Unbound Medicine ER -