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Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry.
Neurosci Lett 1998; 254(3):137-40NL

Abstract

The distribution in the rat brain of fatty acid amide hydrolase (FAAH) an enzyme that catalyzes the hydrolysis of the endogenous cannabinoid anandamide was studied by immunohistochemistry. An immunopurified, polyclonal antibody to the C terminal region of FAAH was used in these studies. The large principal neurons, such as pyramidal cells in the cerebral cortex, the pyramidal cells the hippocampus, Purkinje cells in the cerebellar cortex and the mitral cells in the olfactory bulb, showed the strongest FAAH immunoreactivity. These FAAH-containing principal neurons except the mitral cells in the olfactory bulb are in close proximity with cannabinoid CB1 receptors as revealed by our previous immunohistochemical study. Moderately or lightly stained FAAH-containing neurons were also found in the amygdala, the basal ganglia, the deep cerebellar nuclei, the ventral posterior nuclei of the thalamus, the optic layer and the intermediate white layer of the superior colliculus and the red nucleus in the midbrain, and motor neurons of the spinal cord. These data demonstrate that FAAH is heterogeneously distributed and this distribution exhibits considerable, although not complete, overlap with the distribution of cannabinoid CB1 receptors in rat brain.

Authors+Show Affiliations

Department of Psychology, Brown University, Providence, RI 02912, USA. tk@fizzy.psych.brown.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10214976

Citation

Tsou, K, et al. "Fatty Acid Amide Hydrolase Is Located Preferentially in Large Neurons in the Rat Central Nervous System as Revealed By Immunohistochemistry." Neuroscience Letters, vol. 254, no. 3, 1998, pp. 137-40.
Tsou K, Nogueron MI, Muthian S, et al. Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. Neurosci Lett. 1998;254(3):137-40.
Tsou, K., Nogueron, M. I., Muthian, S., Sañudo-Pena, M. C., Hillard, C. J., Deutsch, D. G., & Walker, J. M. (1998). Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. Neuroscience Letters, 254(3), pp. 137-40.
Tsou K, et al. Fatty Acid Amide Hydrolase Is Located Preferentially in Large Neurons in the Rat Central Nervous System as Revealed By Immunohistochemistry. Neurosci Lett. 1998 Oct 2;254(3):137-40. PubMed PMID: 10214976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. AU - Tsou,K, AU - Nogueron,M I, AU - Muthian,S, AU - Sañudo-Pena,M C, AU - Hillard,C J, AU - Deutsch,D G, AU - Walker,J M, PY - 1999/4/24/pubmed PY - 1999/4/24/medline PY - 1999/4/24/entrez SP - 137 EP - 40 JF - Neuroscience letters JO - Neurosci. Lett. VL - 254 IS - 3 N2 - The distribution in the rat brain of fatty acid amide hydrolase (FAAH) an enzyme that catalyzes the hydrolysis of the endogenous cannabinoid anandamide was studied by immunohistochemistry. An immunopurified, polyclonal antibody to the C terminal region of FAAH was used in these studies. The large principal neurons, such as pyramidal cells in the cerebral cortex, the pyramidal cells the hippocampus, Purkinje cells in the cerebellar cortex and the mitral cells in the olfactory bulb, showed the strongest FAAH immunoreactivity. These FAAH-containing principal neurons except the mitral cells in the olfactory bulb are in close proximity with cannabinoid CB1 receptors as revealed by our previous immunohistochemical study. Moderately or lightly stained FAAH-containing neurons were also found in the amygdala, the basal ganglia, the deep cerebellar nuclei, the ventral posterior nuclei of the thalamus, the optic layer and the intermediate white layer of the superior colliculus and the red nucleus in the midbrain, and motor neurons of the spinal cord. These data demonstrate that FAAH is heterogeneously distributed and this distribution exhibits considerable, although not complete, overlap with the distribution of cannabinoid CB1 receptors in rat brain. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/10214976/Fatty_acid_amide_hydrolase_is_located_preferentially_in_large_neurons_in_the_rat_central_nervous_system_as_revealed_by_immunohistochemistry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394098007009 DB - PRIME DP - Unbound Medicine ER -