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Secondary metabolites from the roots of Astragalus trojanus.
J Nat Prod. 1999 Apr; 62(4):563-8.JN

Abstract

Six novel cycloartane-type glycosides were isolated from the roots of Astragalus trojanus. Two of these, compounds 1 and 2, have (20R, 24S)-epoxy-3beta,6alpha,16beta,25-tetrahydroxycycloartane as the aglycon, while compounds 3-6 possess 3beta,6alpha,16beta,(24S), 25-pentahydroxycycloartane as the aglycon. The saccharide moieties linked to the C-3, C-6, and C-24 or C-25 positions of the aglycons in 1-6 contained either xylopyranose, glucopyranose, rhamnopyranose, or arabinopyranose units. Structure elucidation of compounds 1-6 was accomplished through the extensive use of 1D and 2D NMR techniques. In addition, a new oleanene glycoside (7) and a new tryptophan derivative (8) were also isolated and characterized.

Authors+Show Affiliations

Bedir E
Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey.
Calis I
No affiliation info available
Aquino R
No affiliation info available
Piacente S
No affiliation info available
Pizza C
No affiliation info available

MeSH

Carbohydrate SequenceChromatography, High Pressure LiquidMagnetic Resonance SpectroscopyMass SpectrometryMolecular Sequence DataPlant RootsPlants, MedicinalSaponinsSpectrophotometry, InfraredSpectrophotometry, UltravioletTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10217709

Citation

Bedir, E, et al. "Secondary Metabolites From the Roots of Astragalus Trojanus." Journal of Natural Products, vol. 62, no. 4, 1999, pp. 563-8.
Bedir E, Calis I, Aquino R, et al. Secondary metabolites from the roots of Astragalus trojanus. J Nat Prod. 1999;62(4):563-8.
Bedir, E., Calis, I., Aquino, R., Piacente, S., & Pizza, C. (1999). Secondary metabolites from the roots of Astragalus trojanus. Journal of Natural Products, 62(4), 563-8.
Bedir E, et al. Secondary Metabolites From the Roots of Astragalus Trojanus. J Nat Prod. 1999;62(4):563-8. PubMed PMID: 10217709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Secondary metabolites from the roots of Astragalus trojanus. AU - Bedir,E, AU - Calis,I, AU - Aquino,R, AU - Piacente,S, AU - Pizza,C, PY - 1999/4/28/pubmed PY - 1999/4/28/medline PY - 1999/4/28/entrez SP - 563 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 62 IS - 4 N2 - Six novel cycloartane-type glycosides were isolated from the roots of Astragalus trojanus. Two of these, compounds 1 and 2, have (20R, 24S)-epoxy-3beta,6alpha,16beta,25-tetrahydroxycycloartane as the aglycon, while compounds 3-6 possess 3beta,6alpha,16beta,(24S), 25-pentahydroxycycloartane as the aglycon. The saccharide moieties linked to the C-3, C-6, and C-24 or C-25 positions of the aglycons in 1-6 contained either xylopyranose, glucopyranose, rhamnopyranose, or arabinopyranose units. Structure elucidation of compounds 1-6 was accomplished through the extensive use of 1D and 2D NMR techniques. In addition, a new oleanene glycoside (7) and a new tryptophan derivative (8) were also isolated and characterized. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/10217709/Secondary_metabolites_from_the_roots_of_Astragalus_trojanus_ L2 - https://doi.org/10.1021/np980399t DB - PRIME DP - Unbound Medicine ER -