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Magnesium in diabetes mellitus.
Neth J Med 1999; 54(4):139-46NJ

Abstract

A tendency for magnesium deficiency in patients with diabetes mellitus is well-established. Glucosuria-related hypermagnesiuria, nutritional factors and hyperinsulinaemia-related hypermagnesiuria all can contribute. The plasma magnesium level has been shown to be inversely related to insulin sensitivity. Magnesium supplementation improves insulin sensitivity as well as insulin secretion in patients with type 2 diabetes. Nevertheless, no beneficial effects of oral magnesium supplementation has been demonstrated on glycaemic control either in patients with diabetes type 1 or 2. Oral magnesium supplementation reduced the development of type 2 diabetes in predisposed rats. There are some indications that magnesium decreases blood pressure, but negative results have been observed in trials that were, however, not designed to test effect on blood pressure as primary parameter. Patients with (severe) retinopathy have a lower plasma magnesium level compared to patients without retinopathy and a prospective study has shown the plasma magnesium level to be inversely related to occurrence or progression of retinopathy. Further study on magnesium (supplementation) is warranted in the prevention of type 2 and of (progression of) retinopathy as well as a means to reduce high blood pressure.

Authors+Show Affiliations

Department of Internal Medicine, Utrecht University Hospital, The Netherlands. h.w.devalk@digd.azu.nl

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10218382

Citation

de Valk, H W.. "Magnesium in Diabetes Mellitus." The Netherlands Journal of Medicine, vol. 54, no. 4, 1999, pp. 139-46.
de Valk HW. Magnesium in diabetes mellitus. Neth J Med. 1999;54(4):139-46.
de Valk, H. W. (1999). Magnesium in diabetes mellitus. The Netherlands Journal of Medicine, 54(4), pp. 139-46.
de Valk HW. Magnesium in Diabetes Mellitus. Neth J Med. 1999;54(4):139-46. PubMed PMID: 10218382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium in diabetes mellitus. A1 - de Valk,H W, PY - 1999/4/28/pubmed PY - 1999/4/28/medline PY - 1999/4/28/entrez SP - 139 EP - 46 JF - The Netherlands journal of medicine JO - Neth J Med VL - 54 IS - 4 N2 - A tendency for magnesium deficiency in patients with diabetes mellitus is well-established. Glucosuria-related hypermagnesiuria, nutritional factors and hyperinsulinaemia-related hypermagnesiuria all can contribute. The plasma magnesium level has been shown to be inversely related to insulin sensitivity. Magnesium supplementation improves insulin sensitivity as well as insulin secretion in patients with type 2 diabetes. Nevertheless, no beneficial effects of oral magnesium supplementation has been demonstrated on glycaemic control either in patients with diabetes type 1 or 2. Oral magnesium supplementation reduced the development of type 2 diabetes in predisposed rats. There are some indications that magnesium decreases blood pressure, but negative results have been observed in trials that were, however, not designed to test effect on blood pressure as primary parameter. Patients with (severe) retinopathy have a lower plasma magnesium level compared to patients without retinopathy and a prospective study has shown the plasma magnesium level to be inversely related to occurrence or progression of retinopathy. Further study on magnesium (supplementation) is warranted in the prevention of type 2 and of (progression of) retinopathy as well as a means to reduce high blood pressure. SN - 0300-2977 UR - https://www.unboundmedicine.com/medline/citation/10218382/Magnesium_in_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300297799000054 DB - PRIME DP - Unbound Medicine ER -