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Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network.
Arch Intern Med 1999; 159(7):748-54AI

Abstract

BACKGROUND

Antioxidant supplementation is thought to improve immunity and thereby reduce infectious morbidity. However, few large trials in elderly people have been conducted that include end points for clinical variables.

OBJECTIVE

To determine the effects of long-term daily supplementation with trace elements (zinc sulfate and selenium sulfide) or vitamins (beta carotene, ascorbic acid, and vitamin E) on immunity and the incidence of infections in institutionalized elderly people.

METHODS

This randomized, double-blind, placebo-controlled intervention study included 725 institutionalized elderly patients (>65 years) from 25 geriatric centers in France. Patients received an oral daily supplement of nutritional doses of trace elements (zinc and selenium sulfide) or vitamins (beta carotene, ascorbic acid, and vitamin E) or a placebo within a 2 x 2 factorial design for 2 years.

MAIN OUTCOME MEASURES

Delayed-type hypersensitivity skin response, humoral response to influenza vaccine, and infectious morbidity and mortality.

RESULTS

Correction of specific nutrient deficiencies was observed after 6 months of supplementation and was maintained for the first year, during which there was no effect of any treatment on delayed-type hypersensitivity skin response. Antibody titers after influenza vaccine were higher in groups that received trace elements alone or associated with vitamins, whereas the vitamin group had significantly lower antibody titers (P<.05). The number of patients without respiratory tract infections during the study was higher in groups that received trace elements (P = .06). Supplementation with neither trace elements nor vitamins significantly reduced the incidence of urogenital infections. Survival analysis for the 2 years did not show any differences between the 4 groups.

CONCLUSIONS

Low-dose supplementation of zinc and selenium provides significant improvement in elderly patients by increasing the humoral response after vaccination and could have considerable public health importance by reducing morbidity from respiratory tract infections.

Authors+Show Affiliations

Scientific and Technical Institute for Foods and Nutrition, Conservatiore National des Arts et Méttiers, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10218756

Citation

Girodon, F, et al. "Impact of Trace Elements and Vitamin Supplementation On Immunity and Infections in Institutionalized Elderly Patients: a Randomized Controlled Trial. MIN. VIT. AOX. Geriatric Network." Archives of Internal Medicine, vol. 159, no. 7, 1999, pp. 748-54.
Girodon F, Galan P, Monget AL, et al. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network. Arch Intern Med. 1999;159(7):748-54.
Girodon, F., Galan, P., Monget, A. L., Boutron-Ruault, M. C., Brunet-Lecomte, P., Preziosi, P., ... Herchberg, S. (1999). Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network. Archives of Internal Medicine, 159(7), pp. 748-54.
Girodon F, et al. Impact of Trace Elements and Vitamin Supplementation On Immunity and Infections in Institutionalized Elderly Patients: a Randomized Controlled Trial. MIN. VIT. AOX. Geriatric Network. Arch Intern Med. 1999 Apr 12;159(7):748-54. PubMed PMID: 10218756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network. AU - Girodon,F, AU - Galan,P, AU - Monget,A L, AU - Boutron-Ruault,M C, AU - Brunet-Lecomte,P, AU - Preziosi,P, AU - Arnaud,J, AU - Manuguerra,J C, AU - Herchberg,S, PY - 1999/4/28/pubmed PY - 1999/4/28/medline PY - 1999/4/28/entrez SP - 748 EP - 54 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 159 IS - 7 N2 - BACKGROUND: Antioxidant supplementation is thought to improve immunity and thereby reduce infectious morbidity. However, few large trials in elderly people have been conducted that include end points for clinical variables. OBJECTIVE: To determine the effects of long-term daily supplementation with trace elements (zinc sulfate and selenium sulfide) or vitamins (beta carotene, ascorbic acid, and vitamin E) on immunity and the incidence of infections in institutionalized elderly people. METHODS: This randomized, double-blind, placebo-controlled intervention study included 725 institutionalized elderly patients (>65 years) from 25 geriatric centers in France. Patients received an oral daily supplement of nutritional doses of trace elements (zinc and selenium sulfide) or vitamins (beta carotene, ascorbic acid, and vitamin E) or a placebo within a 2 x 2 factorial design for 2 years. MAIN OUTCOME MEASURES: Delayed-type hypersensitivity skin response, humoral response to influenza vaccine, and infectious morbidity and mortality. RESULTS: Correction of specific nutrient deficiencies was observed after 6 months of supplementation and was maintained for the first year, during which there was no effect of any treatment on delayed-type hypersensitivity skin response. Antibody titers after influenza vaccine were higher in groups that received trace elements alone or associated with vitamins, whereas the vitamin group had significantly lower antibody titers (P<.05). The number of patients without respiratory tract infections during the study was higher in groups that received trace elements (P = .06). Supplementation with neither trace elements nor vitamins significantly reduced the incidence of urogenital infections. Survival analysis for the 2 years did not show any differences between the 4 groups. CONCLUSIONS: Low-dose supplementation of zinc and selenium provides significant improvement in elderly patients by increasing the humoral response after vaccination and could have considerable public health importance by reducing morbidity from respiratory tract infections. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/10218756/Impact_of_trace_elements_and_vitamin_supplementation_on_immunity_and_infections_in_institutionalized_elderly_patients:_a_randomized_controlled_trial__MIN__VIT__AOX__geriatric_network_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/159/pg/748 DB - PRIME DP - Unbound Medicine ER -