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Histamine content does not influence the tolerance of wine in normal subjects.
Allerg Immunol (Paris) 1999; 31(2):45-8AI

Abstract

Histamine has been incriminated as having a responsibility for intolerance reaction to wines. We have made a study by double blind oral provocation test to find the effect of ingestion of a histamine-rich (22.8 mg.l-1) and a histamine free wine in eight healthy subjects. Blood samples were taken at 0, 10, 30 and 45 minutes after ingestion of the wine for measurement of plasma histamine and methylhistamine. Urines were collected 5 hours before and 5 hours after ingestion for measurement of urinary methylhistamine. No subject presented a reaction of intolerance after ingestion of wine rich or poor in histamine. No change in plasma histamine and plasma and urinary methylhistamine was seen. This study shows that the amount of histamine in wine has no clinical or biological effect in healthy subjects, and this emphasized the efficiency in man of the systems for degradation of histamine that is absorbed by the alimentary tract.

Authors+Show Affiliations

Service de Médecine D, Médecine Interne-Immunologie Cliníque et Allergologie Hôpital Central-29, Nancy, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10219426

Citation

Kanny, G, et al. "Histamine Content Does Not Influence the Tolerance of Wine in Normal Subjects." Allergie Et Immunologie, vol. 31, no. 2, 1999, pp. 45-8.
Kanny G, Bauza T, Frémont S, et al. Histamine content does not influence the tolerance of wine in normal subjects. Allerg Immunol (Paris). 1999;31(2):45-8.
Kanny, G., Bauza, T., Frémont, S., Guillemin, F., Blaise, A., Daumas, F., ... Moneret-Vautrin, D. A. (1999). Histamine content does not influence the tolerance of wine in normal subjects. Allergie Et Immunologie, 31(2), pp. 45-8.
Kanny G, et al. Histamine Content Does Not Influence the Tolerance of Wine in Normal Subjects. Allerg Immunol (Paris). 1999;31(2):45-8. PubMed PMID: 10219426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine content does not influence the tolerance of wine in normal subjects. AU - Kanny,G, AU - Bauza,T, AU - Frémont,S, AU - Guillemin,F, AU - Blaise,A, AU - Daumas,F, AU - Cabanis,J C, AU - Nicolas,J P, AU - Moneret-Vautrin,D A, PY - 1999/4/29/pubmed PY - 1999/4/29/medline PY - 1999/4/29/entrez SP - 45 EP - 8 JF - Allergie et immunologie JO - Allerg Immunol (Paris) VL - 31 IS - 2 N2 - Histamine has been incriminated as having a responsibility for intolerance reaction to wines. We have made a study by double blind oral provocation test to find the effect of ingestion of a histamine-rich (22.8 mg.l-1) and a histamine free wine in eight healthy subjects. Blood samples were taken at 0, 10, 30 and 45 minutes after ingestion of the wine for measurement of plasma histamine and methylhistamine. Urines were collected 5 hours before and 5 hours after ingestion for measurement of urinary methylhistamine. No subject presented a reaction of intolerance after ingestion of wine rich or poor in histamine. No change in plasma histamine and plasma and urinary methylhistamine was seen. This study shows that the amount of histamine in wine has no clinical or biological effect in healthy subjects, and this emphasized the efficiency in man of the systems for degradation of histamine that is absorbed by the alimentary tract. SN - 0397-9148 UR - https://www.unboundmedicine.com/medline/citation/10219426/Histamine_content_does_not_influence_the_tolerance_of_wine_in_normal_subjects_ DB - PRIME DP - Unbound Medicine ER -