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Clinical efficacy of lower dose flutamide 125 mg/day in the treatment of hirsutism.
J Endocrinol Invest. 1999 Mar; 22(3):165-8.JE

Abstract

Thirty-four patients with moderate-severe hirsutism were enrolled in this study. The patients received 125 mg/day flutamide for a period of 6 months. Hirsutism score and hormone parameters including FSH, LH, T, free T, androstenedione (A), DHEAS, PRL and sex hormone-binding globulin (SHBG) levels were evaluated in all patients before treatment and repeated at every three-monthly intervals. Hirsutism greatly improved during flutamide therapy, and the hirsutism score significantly decreased at month 3 and 6 from a mean (+/-SD) of 17.19+/-4.55 to 10.75+/-3.84 (p<0.001) and 17.19+/-4.55 to 5.91+/-2.53 (p<0.001), respectively. A significant reduction in hirsutism score (mean%+/-SD) as compared to baseline was observed at 3 months (37.78+/-13.30, p<0.001) and at 6 months (65.47+/-13.49, p<0.001). No significant changes in the levels of hormone and no serious side effects were observed in the patients. The lower dose flutamide, 125 mg/day, is a safe and cost-effective drug in the treatment of hirsutism. Lower dose flutamide may be used in place of high dose flutamide, 250 to 750 mg/day.

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Publisher Full Text

Authors+Show Affiliations

Müderris II
Department of Obstetrics and Gynecology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.
Bayram F
No affiliation info available

MeSH

AdolescentAdultAndrogen AntagonistsAndrostenedioneDehydroepiandrosterone SulfateEstradiolFemaleFlutamideFollicle Stimulating HormoneHirsutismHumansLuteinizing HormoneProlactinSex Hormone-Binding GlobulinTestosterone

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

10219882

Citation

Müderris, I I., and F Bayram. "Clinical Efficacy of Lower Dose Flutamide 125 Mg/day in the Treatment of Hirsutism." Journal of Endocrinological Investigation, vol. 22, no. 3, 1999, pp. 165-8.
Müderris II, Bayram F. Clinical efficacy of lower dose flutamide 125 mg/day in the treatment of hirsutism. J Endocrinol Invest. 1999;22(3):165-8.
Müderris, I. I., & Bayram, F. (1999). Clinical efficacy of lower dose flutamide 125 mg/day in the treatment of hirsutism. Journal of Endocrinological Investigation, 22(3), 165-8.
Müderris II, Bayram F. Clinical Efficacy of Lower Dose Flutamide 125 Mg/day in the Treatment of Hirsutism. J Endocrinol Invest. 1999;22(3):165-8. PubMed PMID: 10219882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical efficacy of lower dose flutamide 125 mg/day in the treatment of hirsutism. AU - Müderris,I I, AU - Bayram,F, PY - 1999/4/29/pubmed PY - 1999/4/29/medline PY - 1999/4/29/entrez SP - 165 EP - 8 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 22 IS - 3 N2 - Thirty-four patients with moderate-severe hirsutism were enrolled in this study. The patients received 125 mg/day flutamide for a period of 6 months. Hirsutism score and hormone parameters including FSH, LH, T, free T, androstenedione (A), DHEAS, PRL and sex hormone-binding globulin (SHBG) levels were evaluated in all patients before treatment and repeated at every three-monthly intervals. Hirsutism greatly improved during flutamide therapy, and the hirsutism score significantly decreased at month 3 and 6 from a mean (+/-SD) of 17.19+/-4.55 to 10.75+/-3.84 (p<0.001) and 17.19+/-4.55 to 5.91+/-2.53 (p<0.001), respectively. A significant reduction in hirsutism score (mean%+/-SD) as compared to baseline was observed at 3 months (37.78+/-13.30, p<0.001) and at 6 months (65.47+/-13.49, p<0.001). No significant changes in the levels of hormone and no serious side effects were observed in the patients. The lower dose flutamide, 125 mg/day, is a safe and cost-effective drug in the treatment of hirsutism. Lower dose flutamide may be used in place of high dose flutamide, 250 to 750 mg/day. SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/10219882/Clinical_efficacy_of_lower_dose_flutamide_125_mg/day_in_the_treatment_of_hirsutism_ L2 - https://link.springer.com/article/10.1007/BF03343536 DB - PRIME DP - Unbound Medicine ER -