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Endemic mycoses: a treatment update.
J Antimicrob Chemother. 1999 Mar; 43(3):321-31.JA

Abstract

Endemic mycoses remain a major public health problem in several countries and they are becoming increasingly frequent with the spread of HIV infection. Amphotericin B remains the drug of choice during the acute stage of life-threatening endemic mycoses occurring in both immunocompetent and immunocompromised hosts. Ketoconazole is effective in non-AIDS patients with non-life-threatening histoplasmosis, blastomycosis, or paracoccidioidomycosis. Itraconazole is the treatment of choice for non-life-threatening Histoplasma capsulatum or Blastomyces dermatitidis infections occurring in immunocompetent individuals and is the most efficient secondary prophylaxis of histoplasmosis in AIDS patients. Itraconazole is also effective in lymphocutaneous and visceral sporotrichosis, in paracoccidioidomycosis, for Penicillum marneffei infection, and is an alternative to amphotericin B for Histoplasma duboisii infection. Coccidioidomycosis may be effectively treated with prolonged and sometimes life-long itraconazole or fluconazole therapy. Fluconazole has relatively poor efficacy against histoplasmosis, blastomycosis and sporotrichosis. New antifungal agents have been tested in vitro or in animal models and may soon be evaluated in clinical trials.

Authors+Show Affiliations

Service de Médecine Interne, Centre de Recherche en Pathologie Infectieuse et Tropicale, Hôpital Avicenne, Université Paris Nord, Bobigny, France. olortho@pasteur.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10223586

Citation

Lortholary, O, et al. "Endemic Mycoses: a Treatment Update." The Journal of Antimicrobial Chemotherapy, vol. 43, no. 3, 1999, pp. 321-31.
Lortholary O, Denning DW, Dupont B. Endemic mycoses: a treatment update. J Antimicrob Chemother. 1999;43(3):321-31.
Lortholary, O., Denning, D. W., & Dupont, B. (1999). Endemic mycoses: a treatment update. The Journal of Antimicrobial Chemotherapy, 43(3), 321-31.
Lortholary O, Denning DW, Dupont B. Endemic Mycoses: a Treatment Update. J Antimicrob Chemother. 1999;43(3):321-31. PubMed PMID: 10223586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endemic mycoses: a treatment update. AU - Lortholary,O, AU - Denning,D W, AU - Dupont,B, PY - 1999/5/1/pubmed PY - 1999/5/1/medline PY - 1999/5/1/entrez SP - 321 EP - 31 JF - The Journal of antimicrobial chemotherapy JO - J. Antimicrob. Chemother. VL - 43 IS - 3 N2 - Endemic mycoses remain a major public health problem in several countries and they are becoming increasingly frequent with the spread of HIV infection. Amphotericin B remains the drug of choice during the acute stage of life-threatening endemic mycoses occurring in both immunocompetent and immunocompromised hosts. Ketoconazole is effective in non-AIDS patients with non-life-threatening histoplasmosis, blastomycosis, or paracoccidioidomycosis. Itraconazole is the treatment of choice for non-life-threatening Histoplasma capsulatum or Blastomyces dermatitidis infections occurring in immunocompetent individuals and is the most efficient secondary prophylaxis of histoplasmosis in AIDS patients. Itraconazole is also effective in lymphocutaneous and visceral sporotrichosis, in paracoccidioidomycosis, for Penicillum marneffei infection, and is an alternative to amphotericin B for Histoplasma duboisii infection. Coccidioidomycosis may be effectively treated with prolonged and sometimes life-long itraconazole or fluconazole therapy. Fluconazole has relatively poor efficacy against histoplasmosis, blastomycosis and sporotrichosis. New antifungal agents have been tested in vitro or in animal models and may soon be evaluated in clinical trials. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/10223586/Endemic_mycoses:_a_treatment_update_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/43.3.321 DB - PRIME DP - Unbound Medicine ER -