Tags

Type your tag names separated by a space and hit enter

Redox metals and neurodegenerative disease.

Abstract

Multiple lines of evidence implicate redox-active transition metals as mediators of oxidative stress in neurodegenerative diseases. Among the recent research discoveries is the finding that transition metals bind to proteins associated with neurodegeneration, including the prion protein. Whereas binding in the latter case may serve an antioxidant function, adventitious binding of metals to other proteins appears to preserve their catalytic redox activity in a manner that disturbs free radical homeostasis. Alterations in the levels of copper- and iron-containing metalloenzymes, involved in processing partially reduced oxygen species, are also likely to contribute to altered redox balance in neurodegenerative diseases. Nonetheless, even in familial forms of amyotrophic lateral sclerosis linked to mutations in superoxide dismutase, it is unclear whether an altered enzyme activity or, indirectly, a disturbance in transition-metal homeostasis is involved in the disease pathogenesis.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Chemistry, Case Western Reserve University, Cleveland, OH44106, USA. LMS3@PO.CWRU.EDU

    ,

    Source

    MeSH

    Amyloid beta-Peptides
    Homeostasis
    Humans
    Metals
    Neurodegenerative Diseases
    Oxidation-Reduction
    Oxidative Stress
    Superoxide Dismutase

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    10226049

    Citation

    Sayre, L M., et al. "Redox Metals and Neurodegenerative Disease." Current Opinion in Chemical Biology, vol. 3, no. 2, 1999, pp. 220-5.
    Sayre LM, Perry G, Smith MA. Redox metals and neurodegenerative disease. Curr Opin Chem Biol. 1999;3(2):220-5.
    Sayre, L. M., Perry, G., & Smith, M. A. (1999). Redox metals and neurodegenerative disease. Current Opinion in Chemical Biology, 3(2), pp. 220-5.
    Sayre LM, Perry G, Smith MA. Redox Metals and Neurodegenerative Disease. Curr Opin Chem Biol. 1999;3(2):220-5. PubMed PMID: 10226049.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Redox metals and neurodegenerative disease. AU - Sayre,L M, AU - Perry,G, AU - Smith,M A, PY - 1999/5/5/pubmed PY - 1999/5/5/medline PY - 1999/5/5/entrez SP - 220 EP - 5 JF - Current opinion in chemical biology JO - Curr Opin Chem Biol VL - 3 IS - 2 N2 - Multiple lines of evidence implicate redox-active transition metals as mediators of oxidative stress in neurodegenerative diseases. Among the recent research discoveries is the finding that transition metals bind to proteins associated with neurodegeneration, including the prion protein. Whereas binding in the latter case may serve an antioxidant function, adventitious binding of metals to other proteins appears to preserve their catalytic redox activity in a manner that disturbs free radical homeostasis. Alterations in the levels of copper- and iron-containing metalloenzymes, involved in processing partially reduced oxygen species, are also likely to contribute to altered redox balance in neurodegenerative diseases. Nonetheless, even in familial forms of amyotrophic lateral sclerosis linked to mutations in superoxide dismutase, it is unclear whether an altered enzyme activity or, indirectly, a disturbance in transition-metal homeostasis is involved in the disease pathogenesis. SN - 1367-5931 UR - https://www.unboundmedicine.com/medline/citation/10226049/Redox_metals_and_neurodegenerative_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1367-5931(99)80035-0 DB - PRIME DP - Unbound Medicine ER -