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Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy.
Hepatogastroenterology. 1999 Jan-Feb; 46(25):31-7.H

Abstract

BACKGROUND/AIMS

Cytological examination of pancreatic juice is useful in the diagnosis of an occult cancer of the pancreas. The early diagnosis of pancreatic carcinoma using traditional radiographic or ultrasonographic methods is extremely difficult.

METHODOLOGY

In order to detect an early pancreatic cancer, cytological examination, measurement of tumor marker, and detection of K-ras point mutation were performed using the samples of pure pancreatic juice aspirated endoscopically in patients who had symptoms or findings that suggested pancreatic disease.

RESULTS

By routine ERP-cytology, positive cytologic results were obtained in 15 (4%) out of 359 patients without a mass. With the aid of intra-operative cytodiagnosis, all 15 occult neoplasms of the pancreas were successfully resected. One patient died from another disease without evidence of recurrence. However, the other patients were alive with no evidence of recurrence for an average of 5.5 years following surgery. The patients who had negative ERP-cytology results were observed, but no further cases of pancreatic cancer were found. The CEA levels in the pure pancreatic juice were significantly higher in patients with pancreatic cancer than in those with pancreatitis. K-ras point mutation at codon 12 was detected not only in cases of pancreatic cancer, but also in cases of chronic pancreatitis as well as control subjects.

CONCLUSIONS

Cytological examination of pancreatic juice is useful in the diagnosis of an early and potentially curable in situ cancer of the pancreas. The CEA levels in the pure pancreatic juice provided useful information for differentiating the pancreatic cancer from chronic pancreatitis. K-ras point mutation at codon 12 in pancreatic juice was considered to be useful in identifying patients at high risk for the development of pancreatic cancer.

Authors+Show Affiliations

Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10228761

Citation

Nakaizumi, A, et al. "Diagnosis of Pancreatic Cancer By Cytology and Measurement of Oncogene and Tumor Markers in Pure Pancreatic Juice Aspirated By Endoscopy." Hepato-gastroenterology, vol. 46, no. 25, 1999, pp. 31-7.
Nakaizumi A, Uehara H, Takenaka A, et al. Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy. Hepatogastroenterology. 1999;46(25):31-7.
Nakaizumi, A., Uehara, H., Takenaka, A., Uedo, N., Sakai, N., Yano, H., Ohigashi, H., Ishikawa, O., Ishiguro, S., Sugano, K., & Tatsuta, M. (1999). Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy. Hepato-gastroenterology, 46(25), 31-7.
Nakaizumi A, et al. Diagnosis of Pancreatic Cancer By Cytology and Measurement of Oncogene and Tumor Markers in Pure Pancreatic Juice Aspirated By Endoscopy. Hepatogastroenterology. 1999 Jan-Feb;46(25):31-7. PubMed PMID: 10228761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy. AU - Nakaizumi,A, AU - Uehara,H, AU - Takenaka,A, AU - Uedo,N, AU - Sakai,N, AU - Yano,H, AU - Ohigashi,H, AU - Ishikawa,O, AU - Ishiguro,S, AU - Sugano,K, AU - Tatsuta,M, PY - 1999/5/6/pubmed PY - 1999/5/6/medline PY - 1999/5/6/entrez SP - 31 EP - 7 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 46 IS - 25 N2 - BACKGROUND/AIMS: Cytological examination of pancreatic juice is useful in the diagnosis of an occult cancer of the pancreas. The early diagnosis of pancreatic carcinoma using traditional radiographic or ultrasonographic methods is extremely difficult. METHODOLOGY: In order to detect an early pancreatic cancer, cytological examination, measurement of tumor marker, and detection of K-ras point mutation were performed using the samples of pure pancreatic juice aspirated endoscopically in patients who had symptoms or findings that suggested pancreatic disease. RESULTS: By routine ERP-cytology, positive cytologic results were obtained in 15 (4%) out of 359 patients without a mass. With the aid of intra-operative cytodiagnosis, all 15 occult neoplasms of the pancreas were successfully resected. One patient died from another disease without evidence of recurrence. However, the other patients were alive with no evidence of recurrence for an average of 5.5 years following surgery. The patients who had negative ERP-cytology results were observed, but no further cases of pancreatic cancer were found. The CEA levels in the pure pancreatic juice were significantly higher in patients with pancreatic cancer than in those with pancreatitis. K-ras point mutation at codon 12 was detected not only in cases of pancreatic cancer, but also in cases of chronic pancreatitis as well as control subjects. CONCLUSIONS: Cytological examination of pancreatic juice is useful in the diagnosis of an early and potentially curable in situ cancer of the pancreas. The CEA levels in the pure pancreatic juice provided useful information for differentiating the pancreatic cancer from chronic pancreatitis. K-ras point mutation at codon 12 in pancreatic juice was considered to be useful in identifying patients at high risk for the development of pancreatic cancer. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/10228761/Diagnosis_of_pancreatic_cancer_by_cytology_and_measurement_of_oncogene_and_tumor_markers_in_pure_pancreatic_juice_aspirated_by_endoscopy_ L2 - http://www.diseaseinfosearch.org/result/5551 DB - PRIME DP - Unbound Medicine ER -