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A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum accompanied with multiple endocrine neoplasia type 1.
Hepatogastroenterology. 1999 Jan-Feb; 46(25):257-60.H

Abstract

A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum accompanied by multiple endocrine neoplasia type-1 (MEN-1) is reported. A 46 year-old female underwent distal gastrectomy due to gastric ulcer 5 years ago. As ulceration of the residual stomach recurred, further examination was performed. Hyperprolactinemia, hypergastrinemia, primary hyperparathyroidism, pancreatic tumor, and duodenal carcinoid were evident, and the diagnoses of Zollinger-Ellison syndrome and MEN-1 were established. The origin of the gastrin secretion was suspected to be from the pancreatic tumor, so sampling of the portal blood was performed. As lesion on the gastrinoma in the pancreas could not be identified, total parathyroidectomy was performed for primary hyperparathyroidism. The level of the gastrin secretion, however, remained high. Partial resection of the duodenum for the duodenal carcinoid and a distal pancreatectomy were carried out concurrently. Immunohistochemical study of the anti-gastrin antibody revealed duodenal tumor cells. Initially, the gastrinoma was thought to be in the pancreas, however, the lesion accompanied with MEN-1 and the Zollinger-Ellison syndrome had occurred in the duodenum.

Authors+Show Affiliations

Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10228803

Citation

Yazawa, K, et al. "A Case of Zollinger-Ellison Syndrome Produced By Gastrinoma in the Duodenum Accompanied With Multiple Endocrine Neoplasia Type 1." Hepato-gastroenterology, vol. 46, no. 25, 1999, pp. 257-60.
Yazawa K, Kuroda T, Watanabe H, et al. A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum accompanied with multiple endocrine neoplasia type 1. Hepatogastroenterology. 1999;46(25):257-60.
Yazawa, K., Kuroda, T., Watanabe, H., Shimozawa, N., Nakata, S., Fujimori, Y., Koide, N., Koike, S., Kajikawa, S., Adachi, W., & Amano, J. (1999). A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum accompanied with multiple endocrine neoplasia type 1. Hepato-gastroenterology, 46(25), 257-60.
Yazawa K, et al. A Case of Zollinger-Ellison Syndrome Produced By Gastrinoma in the Duodenum Accompanied With Multiple Endocrine Neoplasia Type 1. Hepatogastroenterology. 1999 Jan-Feb;46(25):257-60. PubMed PMID: 10228803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum accompanied with multiple endocrine neoplasia type 1. AU - Yazawa,K, AU - Kuroda,T, AU - Watanabe,H, AU - Shimozawa,N, AU - Nakata,S, AU - Fujimori,Y, AU - Koide,N, AU - Koike,S, AU - Kajikawa,S, AU - Adachi,W, AU - Amano,J, PY - 1999/5/6/pubmed PY - 1999/5/6/medline PY - 1999/5/6/entrez SP - 257 EP - 60 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 46 IS - 25 N2 - A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum accompanied by multiple endocrine neoplasia type-1 (MEN-1) is reported. A 46 year-old female underwent distal gastrectomy due to gastric ulcer 5 years ago. As ulceration of the residual stomach recurred, further examination was performed. Hyperprolactinemia, hypergastrinemia, primary hyperparathyroidism, pancreatic tumor, and duodenal carcinoid were evident, and the diagnoses of Zollinger-Ellison syndrome and MEN-1 were established. The origin of the gastrin secretion was suspected to be from the pancreatic tumor, so sampling of the portal blood was performed. As lesion on the gastrinoma in the pancreas could not be identified, total parathyroidectomy was performed for primary hyperparathyroidism. The level of the gastrin secretion, however, remained high. Partial resection of the duodenum for the duodenal carcinoid and a distal pancreatectomy were carried out concurrently. Immunohistochemical study of the anti-gastrin antibody revealed duodenal tumor cells. Initially, the gastrinoma was thought to be in the pancreas, however, the lesion accompanied with MEN-1 and the Zollinger-Ellison syndrome had occurred in the duodenum. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/10228803/A_case_of_Zollinger_Ellison_syndrome_produced_by_gastrinoma_in_the_duodenum_accompanied_with_multiple_endocrine_neoplasia_type_1_ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -