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Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
Hepatogastroenterology. 1999 Jan-Feb; 46(25):532-9.H

Abstract

The significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas is still unclear. The aim of this study was to evaluate the significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas. All of the 78 reports written from 1988 to 1996 on K-ras point mutation of carcinoma, mucin-producing tumors, and hyperplastic epithelia of the pancreas in both surgical or autopsy specimens and pancreatic juice are reviewed. As results, in surgical or autopsy specimens, K-ras mutation was found in 81% of ordinary duct cell carcinoma and in 53% of mucin-producing tumor of the pancreas; this mutation was also found in hyperplastic epithelia in chronic pancreatitis (7%) and in autopsy cases without pancreatic diseases. In pancreatic juice, K-ras mutation was found in 72% of ordinary pancreatic carcinoma and in 53% of mucin-producing tumor, respectively. In conclusion, most previous reports have indicated that K-ras mutation in pancreatic juice is useful for a diagnosis of pancreatic carcinoma. However, since K-ras gene mutation was also detected in non-tumorous lesions, the diagnosis of pancreatic carcinomas is not necessarily correct if it is based solely on the detection of K-ras mutation in pancreatic juice. Future studies should focus on analyzing the amino acid sequence of K-ras mutation or the combination of this mutation with other parameters such as tumor markers in pancreatic juice, to enhance its specificity and accuracy.

Authors+Show Affiliations

First Department of Surgery, Yamagata University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

10228857

Citation

Kimura, W, et al. "Significance of K-ras Codon 12 Point Mutation in Pancreatic Juice in the Diagnosis of Carcinoma of the Pancreas." Hepato-gastroenterology, vol. 46, no. 25, 1999, pp. 532-9.
Kimura W, Zhao B, Futakawa N, et al. Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas. Hepatogastroenterology. 1999;46(25):532-9.
Kimura, W., Zhao, B., Futakawa, N., Muto, T., & Makuuchi, M. (1999). Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas. Hepato-gastroenterology, 46(25), 532-9.
Kimura W, et al. Significance of K-ras Codon 12 Point Mutation in Pancreatic Juice in the Diagnosis of Carcinoma of the Pancreas. Hepatogastroenterology. 1999 Jan-Feb;46(25):532-9. PubMed PMID: 10228857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas. AU - Kimura,W, AU - Zhao,B, AU - Futakawa,N, AU - Muto,T, AU - Makuuchi,M, PY - 1999/5/6/pubmed PY - 1999/5/6/medline PY - 1999/5/6/entrez SP - 532 EP - 9 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 46 IS - 25 N2 - The significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas is still unclear. The aim of this study was to evaluate the significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas. All of the 78 reports written from 1988 to 1996 on K-ras point mutation of carcinoma, mucin-producing tumors, and hyperplastic epithelia of the pancreas in both surgical or autopsy specimens and pancreatic juice are reviewed. As results, in surgical or autopsy specimens, K-ras mutation was found in 81% of ordinary duct cell carcinoma and in 53% of mucin-producing tumor of the pancreas; this mutation was also found in hyperplastic epithelia in chronic pancreatitis (7%) and in autopsy cases without pancreatic diseases. In pancreatic juice, K-ras mutation was found in 72% of ordinary pancreatic carcinoma and in 53% of mucin-producing tumor, respectively. In conclusion, most previous reports have indicated that K-ras mutation in pancreatic juice is useful for a diagnosis of pancreatic carcinoma. However, since K-ras gene mutation was also detected in non-tumorous lesions, the diagnosis of pancreatic carcinomas is not necessarily correct if it is based solely on the detection of K-ras mutation in pancreatic juice. Future studies should focus on analyzing the amino acid sequence of K-ras mutation or the combination of this mutation with other parameters such as tumor markers in pancreatic juice, to enhance its specificity and accuracy. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/10228857/Significance_of_K_ras_codon_12_point_mutation_in_pancreatic_juice_in_the_diagnosis_of_carcinoma_of_the_pancreas_ L2 - https://medlineplus.gov/pancreaticcancer.html DB - PRIME DP - Unbound Medicine ER -