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[Oxidative stress in neurodegeneration].
Rev Neurol 1999 Mar 1-15; 28(5):504-11RN

Abstract

INTRODUCTION

The aetiology of the neuronal death which occurs in neurodegenerative diseases is still unknown. These disorders are of insidious onset and follow an inexorable, gradually progressive course. The best known and most frequent are Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).

DEVELOPMENT

Advances in molecular genetics and neurobiochemistry towards the understanding of processes involved in cell death, suggest the association of phenomena of excito-toxicity and oxidation damage in the selective degeneration of neuronal populations, characteristic of these disorders.

CONCLUSION

The evidence presented here suggests that the species reactive to oxygen (SRO) play a direct part in the aetiology and/or pathogenesis of neurodegenerative disorders, although it is still very difficult to establish whether these reactive species represent the primary etiological factor, or are toxic products secondary to tissue damage.

Authors+Show Affiliations

Departamento de Neurobioquímica, Centro Internacional de Restauración Neurológica, CIREN, La Habana, Cuba. mariae@neubas.sld.cuNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

spa

PubMed ID

10229967

Citation

González-Fraguela, M E., et al. "[Oxidative Stress in Neurodegeneration]." Revista De Neurologia, vol. 28, no. 5, 1999, pp. 504-11.
González-Fraguela ME, Castellano-Benítez O, González-Hoyuela M. [Oxidative stress in neurodegeneration]. Rev Neurol. 1999;28(5):504-11.
González-Fraguela, M. E., Castellano-Benítez, O., & González-Hoyuela, M. (1999). [Oxidative stress in neurodegeneration]. Revista De Neurologia, 28(5), pp. 504-11.
González-Fraguela ME, Castellano-Benítez O, González-Hoyuela M. [Oxidative Stress in Neurodegeneration]. Rev Neurol. 1999;28(5):504-11. PubMed PMID: 10229967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Oxidative stress in neurodegeneration]. AU - González-Fraguela,M E, AU - Castellano-Benítez,O, AU - González-Hoyuela,M, PY - 1999/5/7/pubmed PY - 1999/5/7/medline PY - 1999/5/7/entrez SP - 504 EP - 11 JF - Revista de neurologia JO - Rev Neurol VL - 28 IS - 5 N2 - INTRODUCTION: The aetiology of the neuronal death which occurs in neurodegenerative diseases is still unknown. These disorders are of insidious onset and follow an inexorable, gradually progressive course. The best known and most frequent are Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). DEVELOPMENT: Advances in molecular genetics and neurobiochemistry towards the understanding of processes involved in cell death, suggest the association of phenomena of excito-toxicity and oxidation damage in the selective degeneration of neuronal populations, characteristic of these disorders. CONCLUSION: The evidence presented here suggests that the species reactive to oxygen (SRO) play a direct part in the aetiology and/or pathogenesis of neurodegenerative disorders, although it is still very difficult to establish whether these reactive species represent the primary etiological factor, or are toxic products secondary to tissue damage. SN - 0210-0010 UR - https://www.unboundmedicine.com/medline/citation/10229967/[Oxidative_stress_in_neurodegeneration]_ L2 - https://medlineplus.gov/degenerativenervediseases.html DB - PRIME DP - Unbound Medicine ER -