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Alcohol consumption and Helicobacter pylori infection: results from the German National Health and Nutrition Survey.
Epidemiology 1999; 10(3):214-8E

Abstract

Alcohol has strong antimicrobial activity and stimulates gastric acid secretion. Alcohol consumption may therefore compromise the living conditions of Helicobacter pylori in the stomach. We assessed the relation of alcohol consumption with H. pylori infection among 1,785 participants ages 18-88 in the German National Health and Nutrition Survey. Detailed information on dietary and lifestyle habits was obtained in personal interviews using a standardized food frequency questionnaire. Serum samples were analyzed for H. pylori immunoglobulin G antibodies by enzyme-linked immunosorbent assay. Overall prevalence of H. pylori infection was 39.2%. There was a clear inverse dose-response-relation between reported alcohol consumption and H. pylori infection. The relation persisted after control for potential confounding factors. The adjusted prevalence ratios (95% confidence intervals) for H. pylori infection among persons who consumed up to 10, 10 to 20, and more than 20 gm of alcohol per day compared with non-drinkers were 0.93 (0.77-1.13), 0.82 (0.65-1.04), and 0.71 (0.55-0.92). The inverse relation between alcohol consumption and H. pylori infection was even stronger when individuals with an indication of a recent change of alcohol consumption were excluded from the analysis. These findings support the hypothesis that moderate alcohol consumption may facilitate spontaneous elimination of H. pylori infection among adults.

Authors+Show Affiliations

Department of Epidemiology, University of Ulm, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10230827

Citation

Brenner, H, et al. "Alcohol Consumption and Helicobacter Pylori Infection: Results From the German National Health and Nutrition Survey." Epidemiology (Cambridge, Mass.), vol. 10, no. 3, 1999, pp. 214-8.
Brenner H, Berg G, Lappus N, et al. Alcohol consumption and Helicobacter pylori infection: results from the German National Health and Nutrition Survey. Epidemiology. 1999;10(3):214-8.
Brenner, H., Berg, G., Lappus, N., Kliebsch, U., Bode, G., & Boeing, H. (1999). Alcohol consumption and Helicobacter pylori infection: results from the German National Health and Nutrition Survey. Epidemiology (Cambridge, Mass.), 10(3), pp. 214-8.
Brenner H, et al. Alcohol Consumption and Helicobacter Pylori Infection: Results From the German National Health and Nutrition Survey. Epidemiology. 1999;10(3):214-8. PubMed PMID: 10230827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and Helicobacter pylori infection: results from the German National Health and Nutrition Survey. AU - Brenner,H, AU - Berg,G, AU - Lappus,N, AU - Kliebsch,U, AU - Bode,G, AU - Boeing,H, PY - 1999/5/7/pubmed PY - 1999/5/7/medline PY - 1999/5/7/entrez SP - 214 EP - 8 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 10 IS - 3 N2 - Alcohol has strong antimicrobial activity and stimulates gastric acid secretion. Alcohol consumption may therefore compromise the living conditions of Helicobacter pylori in the stomach. We assessed the relation of alcohol consumption with H. pylori infection among 1,785 participants ages 18-88 in the German National Health and Nutrition Survey. Detailed information on dietary and lifestyle habits was obtained in personal interviews using a standardized food frequency questionnaire. Serum samples were analyzed for H. pylori immunoglobulin G antibodies by enzyme-linked immunosorbent assay. Overall prevalence of H. pylori infection was 39.2%. There was a clear inverse dose-response-relation between reported alcohol consumption and H. pylori infection. The relation persisted after control for potential confounding factors. The adjusted prevalence ratios (95% confidence intervals) for H. pylori infection among persons who consumed up to 10, 10 to 20, and more than 20 gm of alcohol per day compared with non-drinkers were 0.93 (0.77-1.13), 0.82 (0.65-1.04), and 0.71 (0.55-0.92). The inverse relation between alcohol consumption and H. pylori infection was even stronger when individuals with an indication of a recent change of alcohol consumption were excluded from the analysis. These findings support the hypothesis that moderate alcohol consumption may facilitate spontaneous elimination of H. pylori infection among adults. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/10230827/Alcohol_consumption_and_Helicobacter_pylori_infection:_results_from_the_German_National_Health_and_Nutrition_Survey_ L2 - http://Insights.ovid.com/pubmed?pmid=10230827 DB - PRIME DP - Unbound Medicine ER -