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Physical functioning and exercise capacity in patients on dialysis.
Adv Ren Replace Ther. 1999 Apr; 6(2):141-8.AR

Abstract

Patients on dialysis have extremely limited exercise capacity, and poor physical functioning has been linked to low quality of life and high mortality in this population. The reason for the debility of patients on dialysis is far from clear despite years of study. The anemia of chronic renal disease is clearly a contributing factor, but uremic myopathy and resulting decreased muscle oxygen utilization have a significant impact on the physical functioning of patients on dialysis as well. Although it is likely that factors related to uremia adversely affect muscle function, some of the abnormalities demonstrated in uremic muscle are consistent with disuse atrophy. The clear contribution of anemia and the possible role of limited physical activity have led to studies of the effects of erythropoietin and aerobic exercise training on exercise capacity in end-stage renal disease patients. Both of these interventions result in increased exercise capacity. Thus vigorous treatment of anemia and uremia and encouragement of physical activity are important interventions to maximize the physical functioning of patients on dialysis. In addition, more studies are needed to clarify the causes of debility in this population and the impact of interventions on physical functioning, quality of life, and mortality.

Authors+Show Affiliations

Division of Nephrology, San Francisco VA Medical Center, University of California San Francisco, USA. johanse@itsa.ucsf.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10230881

Citation

Johansen, K L.. "Physical Functioning and Exercise Capacity in Patients On Dialysis." Advances in Renal Replacement Therapy, vol. 6, no. 2, 1999, pp. 141-8.
Johansen KL. Physical functioning and exercise capacity in patients on dialysis. Adv Ren Replace Ther. 1999;6(2):141-8.
Johansen, K. L. (1999). Physical functioning and exercise capacity in patients on dialysis. Advances in Renal Replacement Therapy, 6(2), 141-8.
Johansen KL. Physical Functioning and Exercise Capacity in Patients On Dialysis. Adv Ren Replace Ther. 1999;6(2):141-8. PubMed PMID: 10230881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical functioning and exercise capacity in patients on dialysis. A1 - Johansen,K L, PY - 1999/5/7/pubmed PY - 1999/5/7/medline PY - 1999/5/7/entrez SP - 141 EP - 8 JF - Advances in renal replacement therapy JO - Adv Ren Replace Ther VL - 6 IS - 2 N2 - Patients on dialysis have extremely limited exercise capacity, and poor physical functioning has been linked to low quality of life and high mortality in this population. The reason for the debility of patients on dialysis is far from clear despite years of study. The anemia of chronic renal disease is clearly a contributing factor, but uremic myopathy and resulting decreased muscle oxygen utilization have a significant impact on the physical functioning of patients on dialysis as well. Although it is likely that factors related to uremia adversely affect muscle function, some of the abnormalities demonstrated in uremic muscle are consistent with disuse atrophy. The clear contribution of anemia and the possible role of limited physical activity have led to studies of the effects of erythropoietin and aerobic exercise training on exercise capacity in end-stage renal disease patients. Both of these interventions result in increased exercise capacity. Thus vigorous treatment of anemia and uremia and encouragement of physical activity are important interventions to maximize the physical functioning of patients on dialysis. In addition, more studies are needed to clarify the causes of debility in this population and the impact of interventions on physical functioning, quality of life, and mortality. SN - 1073-4449 UR - https://www.unboundmedicine.com/medline/citation/10230881/Physical_functioning_and_exercise_capacity_in_patients_on_dialysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1073444999000205 DB - PRIME DP - Unbound Medicine ER -