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Serum levels of soluble tumor necrosis factor receptors and effects of interferon therapy in patients with chronic hepatitis C virus infection.
Am J Gastroenterol. 1999 May; 94(5):1332-40.AJ

Abstract

OBJECTIVE

The aim of this study was to understand the significance of the tumor necrosis factor receptor (TNFR)-mediated signaling pathway in the pathophysiology of chronic hepatitis C.

METHODS

The serum levels of soluble TNFRs (sTNFRs; sTNFR p55 and sTNFR p75) were measured in 84 patients with chronic hepatitis C virus (HCV) infection (24 sustained responders and 25 nonresponders to interferon [IFN] therapy and 35 patients with persistent normal blood chemistries) and 20 healthy controls, then compared with clinical parameters.

RESULTS

The serum levels of sTNFRs increased in proportion to the severity of liver disease. The levels of sTNFRs revealed significant correlations with the serum levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, and gamma-globulin, but not with the serum levels of HCV-core protein. In the sustained responder group, the levels of sTNFR p75 showed a significant decrease (p < 0.0002) 1 yr after IFN therapy, although the levels of sTNFR p55 did not. The levels of sTNFR p75 were correlated with the serum levels of macrophage-colony stimulating factor both before and after IFN therapy. In the nonresponder group, the levels of both sTNFRs were unaltered after IFN therapy.

CONCLUSIONS

The TNF alpha-TNFRs system, especially the TNFR p75-mediated pathway, is involved in the hepatic inflammation-fibrosis process in chronic hepatitis C. The serum levels of sTNFR p75, but not sTNFR p55, were correlated with the serum levels of macrophage colony stimulating factor in this process.

Authors+Show Affiliations

Itoh Y
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Okanoue T
No affiliation info available
Ohnishi N
No affiliation info available
Sakamoto M
No affiliation info available
Nishioji K
No affiliation info available
Nakagawa Y
No affiliation info available
Minami M
No affiliation info available
Murakami Y
No affiliation info available
Kashima K
No affiliation info available

MeSH

AdultAlanine TransaminaseAntiviral AgentsAspartate AminotransferasesFemaleHepacivirusHepatitis C, ChronicHumansInterferon-alphaMacrophage Colony-Stimulating FactorMaleMiddle AgedReceptors, Tumor Necrosis FactorViral Core Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10235215

Citation

Itoh, Y, et al. "Serum Levels of Soluble Tumor Necrosis Factor Receptors and Effects of Interferon Therapy in Patients With Chronic Hepatitis C Virus Infection." The American Journal of Gastroenterology, vol. 94, no. 5, 1999, pp. 1332-40.
Itoh Y, Okanoue T, Ohnishi N, et al. Serum levels of soluble tumor necrosis factor receptors and effects of interferon therapy in patients with chronic hepatitis C virus infection. Am J Gastroenterol. 1999;94(5):1332-40.
Itoh, Y., Okanoue, T., Ohnishi, N., Sakamoto, M., Nishioji, K., Nakagawa, Y., Minami, M., Murakami, Y., & Kashima, K. (1999). Serum levels of soluble tumor necrosis factor receptors and effects of interferon therapy in patients with chronic hepatitis C virus infection. The American Journal of Gastroenterology, 94(5), 1332-40.
Itoh Y, et al. Serum Levels of Soluble Tumor Necrosis Factor Receptors and Effects of Interferon Therapy in Patients With Chronic Hepatitis C Virus Infection. Am J Gastroenterol. 1999;94(5):1332-40. PubMed PMID: 10235215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of soluble tumor necrosis factor receptors and effects of interferon therapy in patients with chronic hepatitis C virus infection. AU - Itoh,Y, AU - Okanoue,T, AU - Ohnishi,N, AU - Sakamoto,M, AU - Nishioji,K, AU - Nakagawa,Y, AU - Minami,M, AU - Murakami,Y, AU - Kashima,K, PY - 1999/5/11/pubmed PY - 1999/5/11/medline PY - 1999/5/11/entrez SP - 1332 EP - 40 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 94 IS - 5 N2 - OBJECTIVE: The aim of this study was to understand the significance of the tumor necrosis factor receptor (TNFR)-mediated signaling pathway in the pathophysiology of chronic hepatitis C. METHODS: The serum levels of soluble TNFRs (sTNFRs; sTNFR p55 and sTNFR p75) were measured in 84 patients with chronic hepatitis C virus (HCV) infection (24 sustained responders and 25 nonresponders to interferon [IFN] therapy and 35 patients with persistent normal blood chemistries) and 20 healthy controls, then compared with clinical parameters. RESULTS: The serum levels of sTNFRs increased in proportion to the severity of liver disease. The levels of sTNFRs revealed significant correlations with the serum levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, and gamma-globulin, but not with the serum levels of HCV-core protein. In the sustained responder group, the levels of sTNFR p75 showed a significant decrease (p < 0.0002) 1 yr after IFN therapy, although the levels of sTNFR p55 did not. The levels of sTNFR p75 were correlated with the serum levels of macrophage-colony stimulating factor both before and after IFN therapy. In the nonresponder group, the levels of both sTNFRs were unaltered after IFN therapy. CONCLUSIONS: The TNF alpha-TNFRs system, especially the TNFR p75-mediated pathway, is involved in the hepatic inflammation-fibrosis process in chronic hepatitis C. The serum levels of sTNFR p75, but not sTNFR p55, were correlated with the serum levels of macrophage colony stimulating factor in this process. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10235215/Serum_levels_of_soluble_tumor_necrosis_factor_receptors_and_effects_of_interferon_therapy_in_patients_with_chronic_hepatitis_C_virus_infection_ DB - PRIME DP - Unbound Medicine ER -