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Dorzolamide effect on ocular blood flow.
Invest Ophthalmol Vis Sci. 1999 May; 40(6):1270-5.IO

Abstract

PURPOSE

To evaluate the effect of dorzolamide on ocular blood flow in normal and glaucomatous eyes.

METHODS

Twenty-six eyes with documented open-angle glaucoma of 26 patients and 13 normal control eyes of 8 age-matched subjects were included in this study. All eyes underwent color Doppler imaging for measuring peak-systolic velocity, end-diastolic velocity, and resistance index in the ophthalmic and central retinal arteries and the maximal and minimal velocities in the central retinal vein. Eyes were grouped in control and initial and advanced glaucoma categories. Measurements were made in all groups before and after application of topical dorzolamide. Intragroup comparisons between baseline and dorzolamide conditions were made using paired Student's t-test. Intergroup comparisons under baseline conditions between normal and glaucomatous eyes were made by using the one-way ANOVA test. Statistical significance was set at P < 0.05.

RESULTS

The peak-systolic velocity of the central retinal artery in glaucomatous eyes and the end-diastolic velocity of the ophthalmic and central retinal arteries in all groups were significantly higher after application of dorzolamide. The minimal velocity of the central retinal vein showed significantly higher values after dorzolamide, whereas the maximal velocity remained unchanged. The peak-systolic velocity of the ophthalmic artery in all groups and the peak-systolic velocity of the central retinal artery in normal eyes also remained unchanged. The resistance index was significantly lower in the ophthalmic and central retinal arteries in all groups after dorzolamide. The intraocular pressure was significantly reduced in all groups after dorzolamide. Under baseline conditions normal control eyes and glaucomatous eyes showed differences in various measurements. Peak-systolic velocity was significantly lower in glaucomatous eyes than in normal control eyes with the exception of the ophthalmic artery in the initial glaucoma group. End-diastolic velocity was lower in glaucomatous eyes than in control eyes in both arteries. Maximal and minimal velocities of the central retinal vein were lower in glaucomatous eyes than in normal control eyes. Resistance index was higher in glaucomatous eyes than in normal control eyes in the ophthalmic artery but not in the central retinal artery.

CONCLUSIONS

Most hemodynamic parameters of intraocular and periocular vessels improve after application of topical dorzolamide in both normal control and glaucomatous eyes. Dorzolamide should be regarded as a useful drug for treatment of glaucoma not only because it reduces intraocular pressure but also because it improves the ocular blood supply.

Authors+Show Affiliations

Instituto Galego de Oftalmoloxia, Facultad de Medicina, Complejo Hospitalario Universitario de Santiago, Universidad de Santiago, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10235564

Citation

Martinez, A, et al. "Dorzolamide Effect On Ocular Blood Flow." Investigative Ophthalmology & Visual Science, vol. 40, no. 6, 1999, pp. 1270-5.
Martinez A, Gonzalez F, Capeans C, et al. Dorzolamide effect on ocular blood flow. Invest Ophthalmol Vis Sci. 1999;40(6):1270-5.
Martinez, A., Gonzalez, F., Capeans, C., Perez, R., & Sanchez-Salorio, M. (1999). Dorzolamide effect on ocular blood flow. Investigative Ophthalmology & Visual Science, 40(6), 1270-5.
Martinez A, et al. Dorzolamide Effect On Ocular Blood Flow. Invest Ophthalmol Vis Sci. 1999;40(6):1270-5. PubMed PMID: 10235564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorzolamide effect on ocular blood flow. AU - Martinez,A, AU - Gonzalez,F, AU - Capeans,C, AU - Perez,R, AU - Sanchez-Salorio,M, PY - 1999/5/11/pubmed PY - 1999/5/11/medline PY - 1999/5/11/entrez SP - 1270 EP - 5 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 40 IS - 6 N2 - PURPOSE: To evaluate the effect of dorzolamide on ocular blood flow in normal and glaucomatous eyes. METHODS: Twenty-six eyes with documented open-angle glaucoma of 26 patients and 13 normal control eyes of 8 age-matched subjects were included in this study. All eyes underwent color Doppler imaging for measuring peak-systolic velocity, end-diastolic velocity, and resistance index in the ophthalmic and central retinal arteries and the maximal and minimal velocities in the central retinal vein. Eyes were grouped in control and initial and advanced glaucoma categories. Measurements were made in all groups before and after application of topical dorzolamide. Intragroup comparisons between baseline and dorzolamide conditions were made using paired Student's t-test. Intergroup comparisons under baseline conditions between normal and glaucomatous eyes were made by using the one-way ANOVA test. Statistical significance was set at P < 0.05. RESULTS: The peak-systolic velocity of the central retinal artery in glaucomatous eyes and the end-diastolic velocity of the ophthalmic and central retinal arteries in all groups were significantly higher after application of dorzolamide. The minimal velocity of the central retinal vein showed significantly higher values after dorzolamide, whereas the maximal velocity remained unchanged. The peak-systolic velocity of the ophthalmic artery in all groups and the peak-systolic velocity of the central retinal artery in normal eyes also remained unchanged. The resistance index was significantly lower in the ophthalmic and central retinal arteries in all groups after dorzolamide. The intraocular pressure was significantly reduced in all groups after dorzolamide. Under baseline conditions normal control eyes and glaucomatous eyes showed differences in various measurements. Peak-systolic velocity was significantly lower in glaucomatous eyes than in normal control eyes with the exception of the ophthalmic artery in the initial glaucoma group. End-diastolic velocity was lower in glaucomatous eyes than in control eyes in both arteries. Maximal and minimal velocities of the central retinal vein were lower in glaucomatous eyes than in normal control eyes. Resistance index was higher in glaucomatous eyes than in normal control eyes in the ophthalmic artery but not in the central retinal artery. CONCLUSIONS: Most hemodynamic parameters of intraocular and periocular vessels improve after application of topical dorzolamide in both normal control and glaucomatous eyes. Dorzolamide should be regarded as a useful drug for treatment of glaucoma not only because it reduces intraocular pressure but also because it improves the ocular blood supply. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/10235564/Dorzolamide_effect_on_ocular_blood_flow_ L2 - https://iovs.arvojournals.org/article.aspx?volume=40&amp;issue=6&amp;page=1270 DB - PRIME DP - Unbound Medicine ER -