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Celiac sprue among US military veterans: associated disorders and clinical manifestations.

Abstract

The present study aimed to describe the clinical manifestations of celiac sprue related to malnutrition and to analyze the associations between celiac sprue and other diagnoses. A case-control study compared the occurrence of comorbid diagnoses in case and control subjects with and without celiac sprue, respectively. All patients with a primary or secondary diagnosis of celiac sprue (ICD-579.0) who were discharged from hospitals of the Department of Veterans Affairs between 1986 and 1995 were selected as case subjects. In a multivariate logistic regression analysis, the occurrence of celiac disease served as outcome variable, while age, gender, ethnicity, and the comorbid occurrences of other diagnoses served as predictor variables. A total of 458 individual patients with celiac sprue were identified. The data confirmed the known associations of celiac sprue with dermatitis herpetiformis, lactase deficiency, enlargement of lymph nodes, and lymphoma. Celiac sprue was also found to be statistically significantly associated with pancreatic insufficiency, Crohn's disease, functional bowel symptoms, chronic nonalcoholic hepatitis, and pulmonary eosinophilia. The nutritional manifestations associated with celiac disease included nutritional marasmus, cachexia, weight loss, hypocalcemia, osteoporosis, vitamin B-complex deficiency, and various types of iron- and vitamin-deficiency anemias. The large variety of complex associations clearly indicates that celiac sprue is a systemic disease that involves multiple organs and exceeds an isolated nutritional intolerance to gluten.

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  • Authors+Show Affiliations

    ,

    Department of Veterans Affairs Medical Center and The University of New Mexico, Albuquerque 87108, USA.

    ,

    Source

    Digestive diseases and sciences 44:5 1999 May pg 966-72

    MeSH

    Aged
    Case-Control Studies
    Celiac Disease
    Comorbidity
    Female
    Humans
    Male
    Middle Aged
    Military Personnel
    Retrospective Studies
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10235605

    Citation

    Delcò, F, et al. "Celiac Sprue Among US Military Veterans: Associated Disorders and Clinical Manifestations." Digestive Diseases and Sciences, vol. 44, no. 5, 1999, pp. 966-72.
    Delcò F, El-Serag HB, Sonnenberg A. Celiac sprue among US military veterans: associated disorders and clinical manifestations. Dig Dis Sci. 1999;44(5):966-72.
    Delcò, F., El-Serag, H. B., & Sonnenberg, A. (1999). Celiac sprue among US military veterans: associated disorders and clinical manifestations. Digestive Diseases and Sciences, 44(5), pp. 966-72.
    Delcò F, El-Serag HB, Sonnenberg A. Celiac Sprue Among US Military Veterans: Associated Disorders and Clinical Manifestations. Dig Dis Sci. 1999;44(5):966-72. PubMed PMID: 10235605.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Celiac sprue among US military veterans: associated disorders and clinical manifestations. AU - Delcò,F, AU - El-Serag,H B, AU - Sonnenberg,A, PY - 1999/5/11/pubmed PY - 1999/5/11/medline PY - 1999/5/11/entrez SP - 966 EP - 72 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 44 IS - 5 N2 - The present study aimed to describe the clinical manifestations of celiac sprue related to malnutrition and to analyze the associations between celiac sprue and other diagnoses. A case-control study compared the occurrence of comorbid diagnoses in case and control subjects with and without celiac sprue, respectively. All patients with a primary or secondary diagnosis of celiac sprue (ICD-579.0) who were discharged from hospitals of the Department of Veterans Affairs between 1986 and 1995 were selected as case subjects. In a multivariate logistic regression analysis, the occurrence of celiac disease served as outcome variable, while age, gender, ethnicity, and the comorbid occurrences of other diagnoses served as predictor variables. A total of 458 individual patients with celiac sprue were identified. The data confirmed the known associations of celiac sprue with dermatitis herpetiformis, lactase deficiency, enlargement of lymph nodes, and lymphoma. Celiac sprue was also found to be statistically significantly associated with pancreatic insufficiency, Crohn's disease, functional bowel symptoms, chronic nonalcoholic hepatitis, and pulmonary eosinophilia. The nutritional manifestations associated with celiac disease included nutritional marasmus, cachexia, weight loss, hypocalcemia, osteoporosis, vitamin B-complex deficiency, and various types of iron- and vitamin-deficiency anemias. The large variety of complex associations clearly indicates that celiac sprue is a systemic disease that involves multiple organs and exceeds an isolated nutritional intolerance to gluten. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/10235605/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10235605.ui DB - PRIME DP - Unbound Medicine ER -