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Intralesional injection of triamcinolone in the treatment of lichen sclerosus.
J Reprod Med. 1999 Apr; 44(4):332-4.JR

Abstract

OBJECTIVE

To assess intralesional vulvar injections of triamcinolone as an alternative to using topical treatment.

STUDY DESIGN

This was an open trial, in eight patients, of intralesional injection of triamcinolone in patients with symptomatic lichen sclerosus who could not use primary topical treatments. The patients' pretreatment and posttreatment clinical symptoms and gross physical findings were reviewed. In some patients pretreatment and posttreatment biopsies were performed.

RESULTS

There was a decrease in severity scores in the categories of symptoms and physical findings. In four patients who consented to posttreatment biopsy, there was a decrease in severity scores on histopathologic findings.

CONCLUSION

Intralesional injection of triamcinolone hexacetonide into sites of vulvar lichen sclerosus seems to be an effective alternative to using topical agents.

Authors+Show Affiliations

Mazdisnian F
Department of Obstetrics and Gynecology, Olive View-UCLA Medical Center, University of California at Los Angeles School of Medicine, USA.
Degregorio F
No affiliation info available
Mazdisnian F
No affiliation info available
Palmieri A
No affiliation info available

MeSH

Anti-Inflammatory AgentsBiopsyFemaleHumansInjections, IntralesionalLichen Sclerosus et AtrophicusSeverity of Illness IndexTreatment OutcomeTriamcinoloneVulvar Lichen Sclerosus

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

10319301

Citation

Mazdisnian, F, et al. "Intralesional Injection of Triamcinolone in the Treatment of Lichen Sclerosus." The Journal of Reproductive Medicine, vol. 44, no. 4, 1999, pp. 332-4.
Mazdisnian F, Degregorio F, Mazdisnian F, et al. Intralesional injection of triamcinolone in the treatment of lichen sclerosus. J Reprod Med. 1999;44(4):332-4.
Mazdisnian, F., Degregorio, F., Mazdisnian, F., & Palmieri, A. (1999). Intralesional injection of triamcinolone in the treatment of lichen sclerosus. The Journal of Reproductive Medicine, 44(4), 332-4.
Mazdisnian F, et al. Intralesional Injection of Triamcinolone in the Treatment of Lichen Sclerosus. J Reprod Med. 1999;44(4):332-4. PubMed PMID: 10319301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intralesional injection of triamcinolone in the treatment of lichen sclerosus. AU - Mazdisnian,F, AU - Degregorio,F, AU - Mazdisnian,F, AU - Palmieri,A, PY - 1999/5/13/pubmed PY - 1999/5/13/medline PY - 1999/5/13/entrez SP - 332 EP - 4 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 44 IS - 4 N2 - OBJECTIVE: To assess intralesional vulvar injections of triamcinolone as an alternative to using topical treatment. STUDY DESIGN: This was an open trial, in eight patients, of intralesional injection of triamcinolone in patients with symptomatic lichen sclerosus who could not use primary topical treatments. The patients' pretreatment and posttreatment clinical symptoms and gross physical findings were reviewed. In some patients pretreatment and posttreatment biopsies were performed. RESULTS: There was a decrease in severity scores in the categories of symptoms and physical findings. In four patients who consented to posttreatment biopsy, there was a decrease in severity scores on histopathologic findings. CONCLUSION: Intralesional injection of triamcinolone hexacetonide into sites of vulvar lichen sclerosus seems to be an effective alternative to using topical agents. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/10319301/Intralesional_injection_of_triamcinolone_in_the_treatment_of_lichen_sclerosus_ DB - PRIME DP - Unbound Medicine ER -