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Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill.
Biochem Mol Biol Int. 1999 Apr; 47(4):707-14.BM

Abstract

Anti-tumor active polysaccharide against Sarcoma 180 was isolated by DEAE-Sepharose CL-6B and Sepharose 4B column chromatography from the hot-water soluble fraction of the mycelium of liquid-cultured Agaricus blazei mill. This polysaccharide did not react with antibodies of anti-tumor polysaccharides such as lentinan, gliforan, and FIII-2-b which is one of anti-tumor polysaccharides from Agaricus blazei. Moreover, the analyses of 13C-NMR and GC-MS suggested that this polysaccharide was preliminarily glucomannan with a main chain of beta-1,2-linked D-mannopyranosyl residues and beta-D-glucopyranosyl-3-O-beta-D-glucopyranosyl residues as a side chain. This polysaccharide was completely different from the anti-tumor polysaccharide from fruiting body of Agaricus blazei, beta-1,6-glucan.

Authors+Show Affiliations

Graduate School of Science and Technology, Kobe University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10319424

Citation

Mizuno, M, et al. "Anti-tumor Polysaccharide From the Mycelium of Liquid-cultured Agaricus Blazei Mill." Biochemistry and Molecular Biology International, vol. 47, no. 4, 1999, pp. 707-14.
Mizuno M, Minato K, Ito H, et al. Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. Biochem Mol Biol Int. 1999;47(4):707-14.
Mizuno, M., Minato, K., Ito, H., Kawade, M., Terai, H., & Tsuchida, H. (1999). Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. Biochemistry and Molecular Biology International, 47(4), 707-14.
Mizuno M, et al. Anti-tumor Polysaccharide From the Mycelium of Liquid-cultured Agaricus Blazei Mill. Biochem Mol Biol Int. 1999;47(4):707-14. PubMed PMID: 10319424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. AU - Mizuno,M, AU - Minato,K, AU - Ito,H, AU - Kawade,M, AU - Terai,H, AU - Tsuchida,H, PY - 1999/5/13/pubmed PY - 1999/5/13/medline PY - 1999/5/13/entrez SP - 707 EP - 14 JF - Biochemistry and molecular biology international JO - Biochem Mol Biol Int VL - 47 IS - 4 N2 - Anti-tumor active polysaccharide against Sarcoma 180 was isolated by DEAE-Sepharose CL-6B and Sepharose 4B column chromatography from the hot-water soluble fraction of the mycelium of liquid-cultured Agaricus blazei mill. This polysaccharide did not react with antibodies of anti-tumor polysaccharides such as lentinan, gliforan, and FIII-2-b which is one of anti-tumor polysaccharides from Agaricus blazei. Moreover, the analyses of 13C-NMR and GC-MS suggested that this polysaccharide was preliminarily glucomannan with a main chain of beta-1,2-linked D-mannopyranosyl residues and beta-D-glucopyranosyl-3-O-beta-D-glucopyranosyl residues as a side chain. This polysaccharide was completely different from the anti-tumor polysaccharide from fruiting body of Agaricus blazei, beta-1,6-glucan. SN - 1039-9712 UR - https://www.unboundmedicine.com/medline/citation/10319424/Anti_tumor_polysaccharide_from_the_mycelium_of_liquid_cultured_Agaricus_blazei_mill_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:10319424 DB - PRIME DP - Unbound Medicine ER -