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[Effects of aluminum on neurobehavioral function and metabolism of monoamine neurotransmitter].
Zhonghua Yu Fang Yi Xue Za Zhi. 1998 Mar; 32(2):82-4.ZY

Abstract

OBJECTIVE

To evaluate the effects of occupational exposure to aluminum on neurobahavioral function and metabolism of monoamine neurotransmitter.

METHODS

Thirty-three workers exposed to aluminum and 40 controls were studied. Air aluminum concentrations in workplace environment were detected with an atomic absorption spectrophotometer, homovanillic acid (HVA) and vanilylmandellic acid (VMA) in urine and aluminum in serum and urine were detected with high perfolmance liquid chromatography. Neurobehavioral function was tested with Neurobehavioral Core Test Battery recommended by WHO.

RESULTS

Geometric time-weighted average of aluminum in workplace environment was 0.95 mg/m3, ranging from 0.31 to 4.12 mg/m3, and urine aluminum levels in workers exposed to aluminum averaged 12.25 micrograms/L, significantly higher than that in controls (5.78 micrograms/L). There was no significant difference in serum aluminum between the exposed and controls. Both urine VMA and HVA levels were higher in the workers exposed to aluminum, and urine VMA level in the exposed was significantly higher than that in controls. There was significant difference in neurobehavioral test, including Santa Ana, digit symbol and Benton tests between the exposed and control workers.

CONCLUSION

It suggests that occupational exposure to low level of aluminum can affect the neurobehavioral function and metabolism of monoamine neurotransmitter.

Authors+Show Affiliations

Department of Occupational Health, Shanghai Medical University.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

10322803

Citation

Yang, H, et al. "[Effects of Aluminum On Neurobehavioral Function and Metabolism of Monoamine Neurotransmitter]." Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], vol. 32, no. 2, 1998, pp. 82-4.
Yang H, Zheng Y, Liang Y. [Effects of aluminum on neurobehavioral function and metabolism of monoamine neurotransmitter]. Zhonghua Yu Fang Yi Xue Za Zhi. 1998;32(2):82-4.
Yang, H., Zheng, Y., & Liang, Y. (1998). [Effects of aluminum on neurobehavioral function and metabolism of monoamine neurotransmitter]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], 32(2), 82-4.
Yang H, Zheng Y, Liang Y. [Effects of Aluminum On Neurobehavioral Function and Metabolism of Monoamine Neurotransmitter]. Zhonghua Yu Fang Yi Xue Za Zhi. 1998;32(2):82-4. PubMed PMID: 10322803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of aluminum on neurobehavioral function and metabolism of monoamine neurotransmitter]. AU - Yang,H, AU - Zheng,Y, AU - Liang,Y, PY - 1999/5/14/pubmed PY - 1999/5/14/medline PY - 1999/5/14/entrez SP - 82 EP - 4 JF - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] JO - Zhonghua Yu Fang Yi Xue Za Zhi VL - 32 IS - 2 N2 - OBJECTIVE: To evaluate the effects of occupational exposure to aluminum on neurobahavioral function and metabolism of monoamine neurotransmitter. METHODS: Thirty-three workers exposed to aluminum and 40 controls were studied. Air aluminum concentrations in workplace environment were detected with an atomic absorption spectrophotometer, homovanillic acid (HVA) and vanilylmandellic acid (VMA) in urine and aluminum in serum and urine were detected with high perfolmance liquid chromatography. Neurobehavioral function was tested with Neurobehavioral Core Test Battery recommended by WHO. RESULTS: Geometric time-weighted average of aluminum in workplace environment was 0.95 mg/m3, ranging from 0.31 to 4.12 mg/m3, and urine aluminum levels in workers exposed to aluminum averaged 12.25 micrograms/L, significantly higher than that in controls (5.78 micrograms/L). There was no significant difference in serum aluminum between the exposed and controls. Both urine VMA and HVA levels were higher in the workers exposed to aluminum, and urine VMA level in the exposed was significantly higher than that in controls. There was significant difference in neurobehavioral test, including Santa Ana, digit symbol and Benton tests between the exposed and control workers. CONCLUSION: It suggests that occupational exposure to low level of aluminum can affect the neurobehavioral function and metabolism of monoamine neurotransmitter. SN - 0253-9624 UR - https://www.unboundmedicine.com/medline/citation/10322803/[Effects_of_aluminum_on_neurobehavioral_function_and_metabolism_of_monoamine_neurotransmitter]_ L2 - https://medlineplus.gov/occupationalhealth.html DB - PRIME DP - Unbound Medicine ER -