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Increased cancer risk among relatives of nonsmoking lung cancer cases.
Genet Epidemiol 1999; 17(1):1-15GE

Abstract

Lung cancer has been shown to aggregate in families of nonsmoking lung cancer cases with an earlier age at onset. The current study evaluates whether relatives of nonsmoking lung cancer cases are at increased risk of cancers at sites other than lung. Families were identified through 257 population-based, nonsmoking lung cancer cases and 277 population-based, nonsmoking controls residing in metropolitan Detroit. Data were collected for 2,252 relatives of cases and 2,408 relatives of controls. First-degree relatives of nonsmoking lung cancer cases were at 1.52-fold (95% CI, 1.02-2.27) increased risk of cancer of the digestive system after adjustment for each relative's age, race, sex, and smoking status. Relative risk estimates also were elevated, but not significantly, for tobacco-related cancers (RR = 1.39) and breast cancer (RR = 1.72). Among first-degree relatives of younger probands (age 40-59), risk was non-significantly increased 72% (95% CI 0.95-3.10) for all cancers combined and 3.14-fold for cancers of the digestive system (95% CI 0.76-12.9). Nonsmoking relatives of cases were at increased risk of all cancer sites combined (RR = 1.32; 95% CI 1.003-1.73), cancers other than lung (RR = 1.37; 95% CI 1.03-1.82), and digestive system cancers (RR = 2.01; 95% CI 1.20-3.37). These findings of moderate familial aggregation for cancers of the lung, digestive system, breast, and tobacco-related sites suggest that common susceptibility genes may act to increase risk for a variety of cancers in families.

Authors+Show Affiliations

Department of Human Genetics, MCP Hahnemann School of Medicine, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10323181

Citation

Schwartz, A G., et al. "Increased Cancer Risk Among Relatives of Nonsmoking Lung Cancer Cases." Genetic Epidemiology, vol. 17, no. 1, 1999, pp. 1-15.
Schwartz AG, Rothrock M, Yang P, et al. Increased cancer risk among relatives of nonsmoking lung cancer cases. Genet Epidemiol. 1999;17(1):1-15.
Schwartz, A. G., Rothrock, M., Yang, P., & Swanson, G. M. (1999). Increased cancer risk among relatives of nonsmoking lung cancer cases. Genetic Epidemiology, 17(1), pp. 1-15.
Schwartz AG, et al. Increased Cancer Risk Among Relatives of Nonsmoking Lung Cancer Cases. Genet Epidemiol. 1999;17(1):1-15. PubMed PMID: 10323181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased cancer risk among relatives of nonsmoking lung cancer cases. AU - Schwartz,A G, AU - Rothrock,M, AU - Yang,P, AU - Swanson,G M, PY - 1999/5/14/pubmed PY - 2000/6/20/medline PY - 1999/5/14/entrez SP - 1 EP - 15 JF - Genetic epidemiology JO - Genet. Epidemiol. VL - 17 IS - 1 N2 - Lung cancer has been shown to aggregate in families of nonsmoking lung cancer cases with an earlier age at onset. The current study evaluates whether relatives of nonsmoking lung cancer cases are at increased risk of cancers at sites other than lung. Families were identified through 257 population-based, nonsmoking lung cancer cases and 277 population-based, nonsmoking controls residing in metropolitan Detroit. Data were collected for 2,252 relatives of cases and 2,408 relatives of controls. First-degree relatives of nonsmoking lung cancer cases were at 1.52-fold (95% CI, 1.02-2.27) increased risk of cancer of the digestive system after adjustment for each relative's age, race, sex, and smoking status. Relative risk estimates also were elevated, but not significantly, for tobacco-related cancers (RR = 1.39) and breast cancer (RR = 1.72). Among first-degree relatives of younger probands (age 40-59), risk was non-significantly increased 72% (95% CI 0.95-3.10) for all cancers combined and 3.14-fold for cancers of the digestive system (95% CI 0.76-12.9). Nonsmoking relatives of cases were at increased risk of all cancer sites combined (RR = 1.32; 95% CI 1.003-1.73), cancers other than lung (RR = 1.37; 95% CI 1.03-1.82), and digestive system cancers (RR = 2.01; 95% CI 1.20-3.37). These findings of moderate familial aggregation for cancers of the lung, digestive system, breast, and tobacco-related sites suggest that common susceptibility genes may act to increase risk for a variety of cancers in families. SN - 0741-0395 UR - https://www.unboundmedicine.com/medline/citation/10323181/Increased_cancer_risk_among_relatives_of_nonsmoking_lung_cancer_cases_ L2 - https://doi.org/10.1002/(SICI)1098-2272(1999)17:1<1::AID-GEPI1>3.0.CO;2-C DB - PRIME DP - Unbound Medicine ER -