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A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals.
Arthritis Rheum. 1999 May; 42(5):910-7.AR

Abstract

OBJECTIVE

To study the association of cigarette smoking with risk of rheumatoid arthritis (RA), among 377,481 female health professionals in the Women's Health Cohort Study.

METHODS

Subjects completed mailed questionnaires regarding demographics, health habits, including cigarette smoking history, and medical history, including RA diagnosis made by a physician and date of diagnosis. Of 7,697 women who self-reported RA, 3,416 reported seropositive RA. Cox proportional hazards regression models were used to retrospectively assess the associations of smoking intensity and duration with the risk of developing RA or seropositive RA. Cigarette smoking status was treated as a time-varying exposure in these regression models.

RESULTS

In multivariate analyses controlling for age, race, education, age at menarche, pregnancy history, menopausal status, and postmenopausal hormone use, duration of smoking was associated with a significantly increased risk of both RA and seropositive RA (both P < 0.01 for trend), after adjusting for smoking intensity. Women who smoked > or =25 cigarettes/day for more than 20 years experienced a 39% increased risk of RA and 49% increased risk of seropositive RA. However, smoking intensity (number of cigarettes/day) was unrelated to risk of RA or seropositive RA (both P = 0.3 for trend), after adjusting for duration of smoking.

CONCLUSION

Duration, but not intensity, of cigarette smoking is associated with a modest increased risk of RA in women.

Links

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Authors+Show Affiliations

Karlson EW
Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Lee IM
No affiliation info available
Cook NR
No affiliation info available
Manson JE
No affiliation info available
Buring JE
No affiliation info available
Hennekens CH
No affiliation info available

MeSH

Arthritis, RheumatoidCohort StudiesDouble-Blind MethodEstrogensFemaleHumansRetrospective StudiesRisk FactorsSmoking

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10323446

Clinical Trial Links

Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer

Citation

Karlson, E W., et al. "A Retrospective Cohort Study of Cigarette Smoking and Risk of Rheumatoid Arthritis in Female Health Professionals." Arthritis and Rheumatism, vol. 42, no. 5, 1999, pp. 910-7.
Karlson EW, Lee IM, Cook NR, et al. A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals. Arthritis Rheum. 1999;42(5):910-7.
Karlson, E. W., Lee, I. M., Cook, N. R., Manson, J. E., Buring, J. E., & Hennekens, C. H. (1999). A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals. Arthritis and Rheumatism, 42(5), 910-7.
Karlson EW, et al. A Retrospective Cohort Study of Cigarette Smoking and Risk of Rheumatoid Arthritis in Female Health Professionals. Arthritis Rheum. 1999;42(5):910-7. PubMed PMID: 10323446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals. AU - Karlson,E W, AU - Lee,I M, AU - Cook,N R, AU - Manson,J E, AU - Buring,J E, AU - Hennekens,C H, PY - 1999/5/14/pubmed PY - 1999/5/14/medline PY - 1999/5/14/entrez SP - 910 EP - 7 JF - Arthritis and rheumatism JO - Arthritis Rheum VL - 42 IS - 5 N2 - OBJECTIVE: To study the association of cigarette smoking with risk of rheumatoid arthritis (RA), among 377,481 female health professionals in the Women's Health Cohort Study. METHODS: Subjects completed mailed questionnaires regarding demographics, health habits, including cigarette smoking history, and medical history, including RA diagnosis made by a physician and date of diagnosis. Of 7,697 women who self-reported RA, 3,416 reported seropositive RA. Cox proportional hazards regression models were used to retrospectively assess the associations of smoking intensity and duration with the risk of developing RA or seropositive RA. Cigarette smoking status was treated as a time-varying exposure in these regression models. RESULTS: In multivariate analyses controlling for age, race, education, age at menarche, pregnancy history, menopausal status, and postmenopausal hormone use, duration of smoking was associated with a significantly increased risk of both RA and seropositive RA (both P < 0.01 for trend), after adjusting for smoking intensity. Women who smoked > or =25 cigarettes/day for more than 20 years experienced a 39% increased risk of RA and 49% increased risk of seropositive RA. However, smoking intensity (number of cigarettes/day) was unrelated to risk of RA or seropositive RA (both P = 0.3 for trend), after adjusting for duration of smoking. CONCLUSION: Duration, but not intensity, of cigarette smoking is associated with a modest increased risk of RA in women. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/10323446/A_retrospective_cohort_study_of_cigarette_smoking_and_risk_of_rheumatoid_arthritis_in_female_health_professionals_ L2 - https://doi.org/10.1002/1529-0131(199905)42:5&lt;910::AID-ANR9&gt;3.0.CO;2-D DB - PRIME DP - Unbound Medicine ER -