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Diet and its preventive role in prostatic disease.

Abstract

Asian men have much lower incidences of prostate cancer and possibly of benign prostatic hyperplasia (BPH) than their Western counterparts. Vegetarian men also have a lower incidence of prostate cancer than omnivorous males. Both Asian and vegetarian men consume low-fat, high-fibre diets which provide a rich supply of weak dietary oestrogens. These plant or phyto-oestrogens have been proposed as chemopreventive agents, particularly for Asian men and to a lesser extent, for vegetarian men also. The three principal classes of phyto-oestrogens are the isoflavonoids, flavonoids and lignans. Many foods of plant origin contain varying amounts of these compounds and hundreds of plants manifest some degree of oestrogenic activity. Soya, a dietary staple in many parts of Asia, is a major source of the isoflavonoids, daidzein and genistein. Flavonoids are present in high concentration in many fruits, vegetables and crop species. In particular, apigenin and kaempferol are regarded as major flavonoids because of their common occurrence in plants, and their significant concentrations when present. Apples, onions and tea-leaves are excellent sources of flavonoids. Plant lignans are present in many cereals, grains, fruits and vegetables, and give rise to the mammalian lignans, enterodiol and enterolactone; however, the richest source is linseed (flaxseed) and other oilseeds. In addition to their oestrogenic activity, many of these plant compounds can interfere with steroid metabolism and bioavailability, and also inhibit enzymes, such as tyrosine kinase and topoisomerase, which are crucial to cellular proliferation.

Authors+Show Affiliations

,

Oncology Centre, Antwerp, Belgium. louis.denis@skynet.be

,

Source

European urology 35:5-6 1999 pg 377-87

MeSH

Animals
Diet
Global Health
Humans
Incidence
Male
Prognosis
Prostatic Diseases
Prostatic Neoplasms
Risk Assessment
Sensitivity and Specificity

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10325492

Citation

Denis, L, et al. "Diet and Its Preventive Role in Prostatic Disease." European Urology, vol. 35, no. 5-6, 1999, pp. 377-87.
Denis L, Morton MS, Griffiths K. Diet and its preventive role in prostatic disease. Eur Urol. 1999;35(5-6):377-87.
Denis, L., Morton, M. S., & Griffiths, K. (1999). Diet and its preventive role in prostatic disease. European Urology, 35(5-6), pp. 377-87.
Denis L, Morton MS, Griffiths K. Diet and Its Preventive Role in Prostatic Disease. Eur Urol. 1999;35(5-6):377-87. PubMed PMID: 10325492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and its preventive role in prostatic disease. AU - Denis,L, AU - Morton,M S, AU - Griffiths,K, PY - 1999/5/15/pubmed PY - 2000/8/16/medline PY - 1999/5/15/entrez SP - 377 EP - 87 JF - European urology JO - Eur. Urol. VL - 35 IS - 5-6 N2 - Asian men have much lower incidences of prostate cancer and possibly of benign prostatic hyperplasia (BPH) than their Western counterparts. Vegetarian men also have a lower incidence of prostate cancer than omnivorous males. Both Asian and vegetarian men consume low-fat, high-fibre diets which provide a rich supply of weak dietary oestrogens. These plant or phyto-oestrogens have been proposed as chemopreventive agents, particularly for Asian men and to a lesser extent, for vegetarian men also. The three principal classes of phyto-oestrogens are the isoflavonoids, flavonoids and lignans. Many foods of plant origin contain varying amounts of these compounds and hundreds of plants manifest some degree of oestrogenic activity. Soya, a dietary staple in many parts of Asia, is a major source of the isoflavonoids, daidzein and genistein. Flavonoids are present in high concentration in many fruits, vegetables and crop species. In particular, apigenin and kaempferol are regarded as major flavonoids because of their common occurrence in plants, and their significant concentrations when present. Apples, onions and tea-leaves are excellent sources of flavonoids. Plant lignans are present in many cereals, grains, fruits and vegetables, and give rise to the mammalian lignans, enterodiol and enterolactone; however, the richest source is linseed (flaxseed) and other oilseeds. In addition to their oestrogenic activity, many of these plant compounds can interfere with steroid metabolism and bioavailability, and also inhibit enzymes, such as tyrosine kinase and topoisomerase, which are crucial to cellular proliferation. SN - 0302-2838 UR - https://www.unboundmedicine.com/medline/citation/10325492/full_citation L2 - https://medlineplus.gov/prostatecancer.html DB - PRIME DP - Unbound Medicine ER -