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Localization of Mycobacterium leprae to endothelial cells of epineurial and perineurial blood vessels and lymphatics.
Am J Pathol. 1999 May; 154(5):1611-20.AJ

Abstract

Infection of peripheral nerve by Mycobacterium leprae, the histopathological hallmark of leprosy, is a major factor in this disease, but the route and mechanisms by which bacilli localize to peripheral nerve are unknown. Experimentally infected armadillos have recently been recognized as a model of lepromatous neuritis; the major site of early accumulation of M. leprae is epineurial. To determine the epineurial cells involved, 1-cm segments of 44 nerves from armadillos were screened for acid-fast bacilli and thin sections were examined ultrastructurally. Of 596 blocks containing nerve, 36% contained acid-fast bacilli. Overall, M. leprae were found in endothelial cells in 40% of epineurial blood vessels and 75% of lymphatics, and in 25% of vessels intraneurally. Comparison of epineurial and endoneurial findings suggested that colonization of epineurial vessels preceded endoneurial infection. Such colonization of epineurial nutrient vessels may greatly increase the risk of endoneurial M. leprae bacteremia, and also enhance the risk of ischemia following even mild increases in inflammation or mechanical stress. These findings also raise the possibility that early, specific mechanisms in the localization of M. leprae to peripheral nerve may involve adhesion events between M. leprae (or M. leprae-parasitized macrophages) and the endothelial cells of the vasa nervorum.

Authors+Show Affiliations

Department of Research Pathology, G. W. L. Hansen's Disease Center at Louisiana State University, Baton Rouge, LA, USA. dscoll1@lsu.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10329613

Citation

Scollard, D M., et al. "Localization of Mycobacterium Leprae to Endothelial Cells of Epineurial and Perineurial Blood Vessels and Lymphatics." The American Journal of Pathology, vol. 154, no. 5, 1999, pp. 1611-20.
Scollard DM, McCormick G, Allen JL. Localization of Mycobacterium leprae to endothelial cells of epineurial and perineurial blood vessels and lymphatics. Am J Pathol. 1999;154(5):1611-20.
Scollard, D. M., McCormick, G., & Allen, J. L. (1999). Localization of Mycobacterium leprae to endothelial cells of epineurial and perineurial blood vessels and lymphatics. The American Journal of Pathology, 154(5), 1611-20.
Scollard DM, McCormick G, Allen JL. Localization of Mycobacterium Leprae to Endothelial Cells of Epineurial and Perineurial Blood Vessels and Lymphatics. Am J Pathol. 1999;154(5):1611-20. PubMed PMID: 10329613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Localization of Mycobacterium leprae to endothelial cells of epineurial and perineurial blood vessels and lymphatics. AU - Scollard,D M, AU - McCormick,G, AU - Allen,J L, PY - 1999/5/18/pubmed PY - 1999/5/18/medline PY - 1999/5/18/entrez SP - 1611 EP - 20 JF - The American journal of pathology JO - Am J Pathol VL - 154 IS - 5 N2 - Infection of peripheral nerve by Mycobacterium leprae, the histopathological hallmark of leprosy, is a major factor in this disease, but the route and mechanisms by which bacilli localize to peripheral nerve are unknown. Experimentally infected armadillos have recently been recognized as a model of lepromatous neuritis; the major site of early accumulation of M. leprae is epineurial. To determine the epineurial cells involved, 1-cm segments of 44 nerves from armadillos were screened for acid-fast bacilli and thin sections were examined ultrastructurally. Of 596 blocks containing nerve, 36% contained acid-fast bacilli. Overall, M. leprae were found in endothelial cells in 40% of epineurial blood vessels and 75% of lymphatics, and in 25% of vessels intraneurally. Comparison of epineurial and endoneurial findings suggested that colonization of epineurial vessels preceded endoneurial infection. Such colonization of epineurial nutrient vessels may greatly increase the risk of endoneurial M. leprae bacteremia, and also enhance the risk of ischemia following even mild increases in inflammation or mechanical stress. These findings also raise the possibility that early, specific mechanisms in the localization of M. leprae to peripheral nerve may involve adhesion events between M. leprae (or M. leprae-parasitized macrophages) and the endothelial cells of the vasa nervorum. SN - 0002-9440 UR - https://www.unboundmedicine.com/medline/citation/10329613/Localization_of_Mycobacterium_leprae_to_endothelial_cells_of_epineurial_and_perineurial_blood_vessels_and_lymphatics_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9440(10)65414-4 DB - PRIME DP - Unbound Medicine ER -