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Decrease in serum levels of vitamin A and zeaxanthin in patients with colorectal polyp.
Eur J Gastroenterol Hepatol 1999; 11(3):305-8EJ

Abstract

OBJECTIVE

Several retrospective and prospective epidemiological investigations have demonstrated that a diet rich in carotenoids could prevent the development of pre-cancerous and neoplastic lesions of the digestive tract. The aim of this examination was to analyse the correlation between colorectal polyps with different histological classifications and serum carotenoid levels.

DESIGN AND METHODS

A 10 ml blood sample was taken from all of the patients after the colonoscopic diagnosis. The serum levels of vitamin A, lutein, zeaxanthin, alpha- and beta-cryptoxanthin, alpha- and beta-carotene were measured in patients with adenomatous colorectal polyp (n = 59, 35 males, 24 females) by high-pressure liquid chromatography (HPLC) and compared with those in healthy subjects (n = 20, 10 males, 10 females). The patients were separated into four groups depending on their histological findings.

RESULTS

The serum levels of vitamin A and zeaxanthin were significantly lower in all patients with polyps (vitamin A: 0.913 +/- 0.112 micromol/l, zeaxanthin: 0.071 +/- 0.012 micromol/l) than in the control healthy group (vitamin A: 2.036 +/- 0.354 micromol/l, zeaxanthin: 0.138 +/- 0.048 micromol/l). The lowest levels were found in patients with focal adenocarcinoma in the polyp. There were no significant differences in the serum levels of other carotenoids. The serum levels of cholesterol, haemoglobin, total protein and albumin were normal in these patients.

CONCLUSIONS

There are close and inverse correlations between the serum level of carotenoids and colorectal polyps with different histological grades. The low mean carotenoid levels in patients with adenocarcinoma in the polyp indicate that deficiency of carotenoids may be an important factor in the development of colorectal cancer.

Authors+Show Affiliations

First Department of Medicine, University Medical School of Pécs, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10333204

Citation

Rumi, G, et al. "Decrease in Serum Levels of Vitamin a and Zeaxanthin in Patients With Colorectal Polyp." European Journal of Gastroenterology & Hepatology, vol. 11, no. 3, 1999, pp. 305-8.
Rumi G, Szabó I, Vincze A, et al. Decrease in serum levels of vitamin A and zeaxanthin in patients with colorectal polyp. Eur J Gastroenterol Hepatol. 1999;11(3):305-8.
Rumi, G., Szabó, I., Vincze, A., Matus, Z., Tóth, G., Rumi, G., & Mózsik, G. (1999). Decrease in serum levels of vitamin A and zeaxanthin in patients with colorectal polyp. European Journal of Gastroenterology & Hepatology, 11(3), pp. 305-8.
Rumi G, et al. Decrease in Serum Levels of Vitamin a and Zeaxanthin in Patients With Colorectal Polyp. Eur J Gastroenterol Hepatol. 1999;11(3):305-8. PubMed PMID: 10333204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decrease in serum levels of vitamin A and zeaxanthin in patients with colorectal polyp. AU - Rumi,G,Jr AU - Szabó,I, AU - Vincze,A, AU - Matus,Z, AU - Tóth,G, AU - Rumi,G, AU - Mózsik,G, PY - 1999/5/20/pubmed PY - 2001/3/28/medline PY - 1999/5/20/entrez SP - 305 EP - 8 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 11 IS - 3 N2 - OBJECTIVE: Several retrospective and prospective epidemiological investigations have demonstrated that a diet rich in carotenoids could prevent the development of pre-cancerous and neoplastic lesions of the digestive tract. The aim of this examination was to analyse the correlation between colorectal polyps with different histological classifications and serum carotenoid levels. DESIGN AND METHODS: A 10 ml blood sample was taken from all of the patients after the colonoscopic diagnosis. The serum levels of vitamin A, lutein, zeaxanthin, alpha- and beta-cryptoxanthin, alpha- and beta-carotene were measured in patients with adenomatous colorectal polyp (n = 59, 35 males, 24 females) by high-pressure liquid chromatography (HPLC) and compared with those in healthy subjects (n = 20, 10 males, 10 females). The patients were separated into four groups depending on their histological findings. RESULTS: The serum levels of vitamin A and zeaxanthin were significantly lower in all patients with polyps (vitamin A: 0.913 +/- 0.112 micromol/l, zeaxanthin: 0.071 +/- 0.012 micromol/l) than in the control healthy group (vitamin A: 2.036 +/- 0.354 micromol/l, zeaxanthin: 0.138 +/- 0.048 micromol/l). The lowest levels were found in patients with focal adenocarcinoma in the polyp. There were no significant differences in the serum levels of other carotenoids. The serum levels of cholesterol, haemoglobin, total protein and albumin were normal in these patients. CONCLUSIONS: There are close and inverse correlations between the serum level of carotenoids and colorectal polyps with different histological grades. The low mean carotenoid levels in patients with adenocarcinoma in the polyp indicate that deficiency of carotenoids may be an important factor in the development of colorectal cancer. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/10333204/Decrease_in_serum_levels_of_vitamin_A_and_zeaxanthin_in_patients_with_colorectal_polyp_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10333204.ui DB - PRIME DP - Unbound Medicine ER -