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Pathophysiology of variceal bleeding.
Gastrointest Endosc Clin N Am. 1999 Apr; 9(2):167-74.GE

Abstract

A review of the pathophysiology of variceal bleeding, with a discussion of the pathogenesis of portal hypertension, formation of varices, and bleeding from varices. Portal hypertension results from increases in portal flow and portal vascular resistance. The factors increasing portal blood flow are primarily humoral. Resistance to portal flow has fixed and variable components. Elevated portal pressure leads to variceal formation. Variceal bleeding is dependent on portal pressure, variceal size, and variceal wall thickness.

Authors+Show Affiliations

Roberts LR
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Kamath PS
No affiliation info available

MeSH

AnimalsBlood Flow VelocityEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansHypertension, PortalLiver CirrhosisPortal PressurePortal SystemVascular Resistance

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10333436

Citation

Roberts, L R., and P S. Kamath. "Pathophysiology of Variceal Bleeding." Gastrointestinal Endoscopy Clinics of North America, vol. 9, no. 2, 1999, pp. 167-74.
Roberts LR, Kamath PS. Pathophysiology of variceal bleeding. Gastrointest Endosc Clin N Am. 1999;9(2):167-74.
Roberts, L. R., & Kamath, P. S. (1999). Pathophysiology of variceal bleeding. Gastrointestinal Endoscopy Clinics of North America, 9(2), 167-74.
Roberts LR, Kamath PS. Pathophysiology of Variceal Bleeding. Gastrointest Endosc Clin N Am. 1999;9(2):167-74. PubMed PMID: 10333436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathophysiology of variceal bleeding. AU - Roberts,L R, AU - Kamath,P S, PY - 1999/5/20/pubmed PY - 1999/5/20/medline PY - 1999/5/20/entrez SP - 167 EP - 74 JF - Gastrointestinal endoscopy clinics of North America JO - Gastrointest Endosc Clin N Am VL - 9 IS - 2 N2 - A review of the pathophysiology of variceal bleeding, with a discussion of the pathogenesis of portal hypertension, formation of varices, and bleeding from varices. Portal hypertension results from increases in portal flow and portal vascular resistance. The factors increasing portal blood flow are primarily humoral. Resistance to portal flow has fixed and variable components. Elevated portal pressure leads to variceal formation. Variceal bleeding is dependent on portal pressure, variceal size, and variceal wall thickness. SN - 1052-5157 UR - https://www.unboundmedicine.com/medline/citation/10333436/Pathophysiology_of_variceal_bleeding_ L2 - https://medlineplus.gov/gastrointestinalbleeding.html DB - PRIME DP - Unbound Medicine ER -