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Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients.
Diabetes Care 1999; 22(1):10-8DC

Abstract

OBJECTIVE

To evaluate the effects of varying the glycemic index (GI) of carbohydrate-rich foods on metabolic control in type 2 diabetic patients.

RESEARCH DESIGN AND METHODS

In a randomized crossover study, 20 patients, 5 women and 15 men, were given preweighed diets with different GIs during two consecutive 24-day periods. Both diets were composed in accordance with dietary recommendations for people with diabetes. The macronutrient composition and type and amount of dietary fiber were identical. Differences in GI were achieved mainly by altering the structure of the starchy foods.

RESULTS

Peripheral insulin sensitivity increased significantly and fasting plasma glucose decreased during both treatment periods. There was a significant difference in the changes of serum fructosamine concentrations between the diets (P < 0.05). The incremental area under the curve for both blood glucose and plasma insulin was approximately 30% lower after the low- than after the high-GI diet. LDL cholesterol was significantly lowered on both diets, with a significantly more pronounced reduction on the low-GI diet. Plasminogen activator inhibitor-1 activity was normalized on the low-GI diet, (-54%, P < 0.001), but remained unchanged on the high-GI diet.

CONCLUSIONS

A diet characterized by low-GI starchy foods lowers the glucose and insulin responses throughout the day and improves the lipid profile and capacity for fibrinolysis, suggesting a therapeutic potential in diabetes.

Authors+Show Affiliations

Clinical Nutrition Research Unit, Uppsala University, Sweden. anette.jarvi@geriatrik.lul.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10333897

Citation

Järvi, A E., et al. "Improved Glycemic Control and Lipid Profile and Normalized Fibrinolytic Activity On a Low-glycemic Index Diet in Type 2 Diabetic Patients." Diabetes Care, vol. 22, no. 1, 1999, pp. 10-8.
Järvi AE, Karlström BE, Granfeldt YE, et al. Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients. Diabetes Care. 1999;22(1):10-8.
Järvi, A. E., Karlström, B. E., Granfeldt, Y. E., Björck, I. E., Asp, N. G., & Vessby, B. O. (1999). Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients. Diabetes Care, 22(1), pp. 10-8.
Järvi AE, et al. Improved Glycemic Control and Lipid Profile and Normalized Fibrinolytic Activity On a Low-glycemic Index Diet in Type 2 Diabetic Patients. Diabetes Care. 1999;22(1):10-8. PubMed PMID: 10333897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients. AU - Järvi,A E, AU - Karlström,B E, AU - Granfeldt,Y E, AU - Björck,I E, AU - Asp,N G, AU - Vessby,B O, PY - 1999/5/20/pubmed PY - 1999/5/20/medline PY - 1999/5/20/entrez SP - 10 EP - 8 JF - Diabetes care JO - Diabetes Care VL - 22 IS - 1 N2 - OBJECTIVE: To evaluate the effects of varying the glycemic index (GI) of carbohydrate-rich foods on metabolic control in type 2 diabetic patients. RESEARCH DESIGN AND METHODS: In a randomized crossover study, 20 patients, 5 women and 15 men, were given preweighed diets with different GIs during two consecutive 24-day periods. Both diets were composed in accordance with dietary recommendations for people with diabetes. The macronutrient composition and type and amount of dietary fiber were identical. Differences in GI were achieved mainly by altering the structure of the starchy foods. RESULTS: Peripheral insulin sensitivity increased significantly and fasting plasma glucose decreased during both treatment periods. There was a significant difference in the changes of serum fructosamine concentrations between the diets (P < 0.05). The incremental area under the curve for both blood glucose and plasma insulin was approximately 30% lower after the low- than after the high-GI diet. LDL cholesterol was significantly lowered on both diets, with a significantly more pronounced reduction on the low-GI diet. Plasminogen activator inhibitor-1 activity was normalized on the low-GI diet, (-54%, P < 0.001), but remained unchanged on the high-GI diet. CONCLUSIONS: A diet characterized by low-GI starchy foods lowers the glucose and insulin responses throughout the day and improves the lipid profile and capacity for fibrinolysis, suggesting a therapeutic potential in diabetes. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/10333897/Improved_glycemic_control_and_lipid_profile_and_normalized_fibrinolytic_activity_on_a_low_glycemic_index_diet_in_type_2_diabetic_patients_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=10333897 DB - PRIME DP - Unbound Medicine ER -