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Yoghurt enriched with Lactobacillus acidophilus does not lower blood lipids in healthy men and women with normal to borderline high serum cholesterol levels.
Eur J Clin Nutr 1999; 53(4):277-80EJ

Abstract

OBJECTIVE

To investigate whether intake of Lactobacillus acidophilus strain L-1 lowers serum cholesterol in healthy men and women.

DESIGN

Randomised, placebo-controlled parallel trial.

SETTING

Subjects were free-living. Blood sampling and distribution of yoghurts were administered at a local hospital.

SUBJECTS

Seventy-eight adult men and women with cholesterol levels of 3.9-7.8 mmol/L (mean +/- s.d., 5.4+/-0.7).

INTERVENTIONS

Subjects consumed 500 mL of control yoghurt daily for two weeks. They were then randomly allocated to receive 500 mL per day of control yoghurt or of yoghurt enriched with Lactobacillus acidophilus L-1 for another six weeks. The yoghurts were spiked with a trace of lithium; compliance as assessed by plasma lithium was excellent.

RESULTS

Energy and nutrient intake was constant, and identical for the two groups. Mean body weight was stable. Baseline blood lipid concentrations in the control and treatment groups were highly similar. The effect of consumption of Lactobacillus acidophilus L-1 vs. control on total cholesterol was -0.02 mmol/L (95% CI, -0.18-0.15) after three weeks and 0.04 mmol/L (95% CI, -0.12-0.20) after six weeks. Serum LDL and HDL-cholesterol and triacylglycerol levels were also unaffected.

CONCLUSIONS

Yoghurt enriched with Lactobacillus acidophilus L-1 does not lower serum cholesterol in men and women with normal to borderline high cholesterol levels.

Authors+Show Affiliations

Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10334653

Citation

de Roos, N M., et al. "Yoghurt Enriched With Lactobacillus Acidophilus Does Not Lower Blood Lipids in Healthy Men and Women With Normal to Borderline High Serum Cholesterol Levels." European Journal of Clinical Nutrition, vol. 53, no. 4, 1999, pp. 277-80.
de Roos NM, Schouten G, Katan MB. Yoghurt enriched with Lactobacillus acidophilus does not lower blood lipids in healthy men and women with normal to borderline high serum cholesterol levels. Eur J Clin Nutr. 1999;53(4):277-80.
de Roos, N. M., Schouten, G., & Katan, M. B. (1999). Yoghurt enriched with Lactobacillus acidophilus does not lower blood lipids in healthy men and women with normal to borderline high serum cholesterol levels. European Journal of Clinical Nutrition, 53(4), pp. 277-80.
de Roos NM, Schouten G, Katan MB. Yoghurt Enriched With Lactobacillus Acidophilus Does Not Lower Blood Lipids in Healthy Men and Women With Normal to Borderline High Serum Cholesterol Levels. Eur J Clin Nutr. 1999;53(4):277-80. PubMed PMID: 10334653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Yoghurt enriched with Lactobacillus acidophilus does not lower blood lipids in healthy men and women with normal to borderline high serum cholesterol levels. AU - de Roos,N M, AU - Schouten,G, AU - Katan,M B, PY - 1999/5/20/pubmed PY - 1999/5/20/medline PY - 1999/5/20/entrez SP - 277 EP - 80 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 53 IS - 4 N2 - OBJECTIVE: To investigate whether intake of Lactobacillus acidophilus strain L-1 lowers serum cholesterol in healthy men and women. DESIGN: Randomised, placebo-controlled parallel trial. SETTING: Subjects were free-living. Blood sampling and distribution of yoghurts were administered at a local hospital. SUBJECTS: Seventy-eight adult men and women with cholesterol levels of 3.9-7.8 mmol/L (mean +/- s.d., 5.4+/-0.7). INTERVENTIONS: Subjects consumed 500 mL of control yoghurt daily for two weeks. They were then randomly allocated to receive 500 mL per day of control yoghurt or of yoghurt enriched with Lactobacillus acidophilus L-1 for another six weeks. The yoghurts were spiked with a trace of lithium; compliance as assessed by plasma lithium was excellent. RESULTS: Energy and nutrient intake was constant, and identical for the two groups. Mean body weight was stable. Baseline blood lipid concentrations in the control and treatment groups were highly similar. The effect of consumption of Lactobacillus acidophilus L-1 vs. control on total cholesterol was -0.02 mmol/L (95% CI, -0.18-0.15) after three weeks and 0.04 mmol/L (95% CI, -0.12-0.20) after six weeks. Serum LDL and HDL-cholesterol and triacylglycerol levels were also unaffected. CONCLUSIONS: Yoghurt enriched with Lactobacillus acidophilus L-1 does not lower serum cholesterol in men and women with normal to borderline high cholesterol levels. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/10334653/Yoghurt_enriched_with_Lactobacillus_acidophilus_does_not_lower_blood_lipids_in_healthy_men_and_women_with_normal_to_borderline_high_serum_cholesterol_levels_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -