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Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects.
Eur J Clin Nutr. 1999 Apr; 53(4):319-27.EJ

Abstract

OBJECTIVE

To investigate the dose-response relationship between cholesterol lowering and three different, relatively low intake levels of plant sterols (0.83, 1.61, 3.24 g/d) from spreads. To investigate the effects on lipid-soluble (pro)vitamins.

DESIGN

A randomized double-blind placebo controlled balanced incomplete Latin square design using five spreads and four periods. The five study spreads included butter, a commercially available spread and three experimental spreads fortified with three different concentrations of plant sterols.

SUBJECTS

One hundred apparently healthy normocholesterolaemic and mildly hypercholesterolaemic volunteers participated.

INTERVENTIONS

Each subject consumed four spreads, each for a period of 3.5 week.

RESULTS

Compared to the control spread, total cholesterol decreased by 0.26 (CI: 0.15-0.36), 0.31 (CI: 0.20-0.41) and 0.35 (CI: 0.25-0.46) mmol/L, for daily consumption of 0.83, 1.61 and 3.24 g plant sterols, respectively. For LDL-cholesterol these decreases were 0.20 (CI: 0.10-0.31), 0.26 (CI: 0.15-0.36) and 0.30 (CI: 0.20-0.41). Decreases in the LDL/HDL ratio were 0.13 (CI: 0.04-0.22), 0.16 (CI: 0.07-0.24) and 0.16 (CI: 0.07-0.24) units, respectively. Differences in cholesterol reductions between the plant sterol doses consumed were not statistically significant. Plasma vitamin K1 and 25-OH-vitamin D and lipid standardized plasma lycopene and alpha-tocopherol were not affected by consumption of plant sterol enriched spreads, but lipid standardized plasma (alpha + beta)-carotene concentrations were decreased by about 11 and 19% by daily consumption of 0.83 and 3.24 g plant sterols in spread, respectively.

CONCLUSIONS

The three relatively low dosages of plant sterols had a significant cholesterol lowering effect ranging from 4.9-6.8%, 6.7-9.9% and 6.5-7.9%, for total, LDL-cholesterol and the LDL/HDL cholesterol ratio, respectively, without substantially affecting lipid soluble (pro)vitamins. No significant differences in cholesterol lowering effect between the three dosages of plant sterols could be detected. This study would support that consumption of about 1.6 g of plant sterols per day will beneficially affect plasma cholesterol concentrations without seriously affecting plasma carotenoid concentrations.

Authors+Show Affiliations

TNO Nutrition and Food Research Institute, Zeist, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10334658

Citation

Hendriks, H F., et al. "Spreads Enriched With Three Different Levels of Vegetable Oil Sterols and the Degree of Cholesterol Lowering in Normocholesterolaemic and Mildly Hypercholesterolaemic Subjects." European Journal of Clinical Nutrition, vol. 53, no. 4, 1999, pp. 319-27.
Hendriks HF, Weststrate JA, van Vliet T, et al. Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr. 1999;53(4):319-27.
Hendriks, H. F., Weststrate, J. A., van Vliet, T., & Meijer, G. W. (1999). Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. European Journal of Clinical Nutrition, 53(4), 319-27.
Hendriks HF, et al. Spreads Enriched With Three Different Levels of Vegetable Oil Sterols and the Degree of Cholesterol Lowering in Normocholesterolaemic and Mildly Hypercholesterolaemic Subjects. Eur J Clin Nutr. 1999;53(4):319-27. PubMed PMID: 10334658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. AU - Hendriks,H F, AU - Weststrate,J A, AU - van Vliet,T, AU - Meijer,G W, PY - 1999/5/20/pubmed PY - 1999/5/20/medline PY - 1999/5/20/entrez SP - 319 EP - 27 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 53 IS - 4 N2 - OBJECTIVE: To investigate the dose-response relationship between cholesterol lowering and three different, relatively low intake levels of plant sterols (0.83, 1.61, 3.24 g/d) from spreads. To investigate the effects on lipid-soluble (pro)vitamins. DESIGN: A randomized double-blind placebo controlled balanced incomplete Latin square design using five spreads and four periods. The five study spreads included butter, a commercially available spread and three experimental spreads fortified with three different concentrations of plant sterols. SUBJECTS: One hundred apparently healthy normocholesterolaemic and mildly hypercholesterolaemic volunteers participated. INTERVENTIONS: Each subject consumed four spreads, each for a period of 3.5 week. RESULTS: Compared to the control spread, total cholesterol decreased by 0.26 (CI: 0.15-0.36), 0.31 (CI: 0.20-0.41) and 0.35 (CI: 0.25-0.46) mmol/L, for daily consumption of 0.83, 1.61 and 3.24 g plant sterols, respectively. For LDL-cholesterol these decreases were 0.20 (CI: 0.10-0.31), 0.26 (CI: 0.15-0.36) and 0.30 (CI: 0.20-0.41). Decreases in the LDL/HDL ratio were 0.13 (CI: 0.04-0.22), 0.16 (CI: 0.07-0.24) and 0.16 (CI: 0.07-0.24) units, respectively. Differences in cholesterol reductions between the plant sterol doses consumed were not statistically significant. Plasma vitamin K1 and 25-OH-vitamin D and lipid standardized plasma lycopene and alpha-tocopherol were not affected by consumption of plant sterol enriched spreads, but lipid standardized plasma (alpha + beta)-carotene concentrations were decreased by about 11 and 19% by daily consumption of 0.83 and 3.24 g plant sterols in spread, respectively. CONCLUSIONS: The three relatively low dosages of plant sterols had a significant cholesterol lowering effect ranging from 4.9-6.8%, 6.7-9.9% and 6.5-7.9%, for total, LDL-cholesterol and the LDL/HDL cholesterol ratio, respectively, without substantially affecting lipid soluble (pro)vitamins. No significant differences in cholesterol lowering effect between the three dosages of plant sterols could be detected. This study would support that consumption of about 1.6 g of plant sterols per day will beneficially affect plasma cholesterol concentrations without seriously affecting plasma carotenoid concentrations. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/10334658/Spreads_enriched_with_three_different_levels_of_vegetable_oil_sterols_and_the_degree_of_cholesterol_lowering_in_normocholesterolaemic_and_mildly_hypercholesterolaemic_subjects_ L2 - https://doi.org/10.1038/sj.ejcn.1600728 DB - PRIME DP - Unbound Medicine ER -