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Small supplements of N-3 fatty acids change serum low density lipoprotein composition by decreasing phospholid and apolipoprotein B concentrations in young adult women.
Eur J Nutr. 1999 Feb; 38(1):20-7.EJ

Abstract

In order to investigate the effect of a short-term application of marine n-3 polyunsaturated fatty acids on the composition of serum very low density lipoproteins (VLDL), low density lipoproteins (LDL), and high density lipoproteins (HDL), nine women aged 29 +/- 4.2 years, following a diet with a SFA/MUFA/PUFA profile of 2.4/3/1, received supplements of six capsules daily, each capsule containing 0.137 g of n-3 fatty acids (14.5% eicosapentaenoic acid (EPA) and 8.9% docosahexaenoic acid (DHA)) for 10 d. Food consumption, assessed during two 10-days periods indicates that percentage contribution of SFA, MUFA, and PUFA to the daily energy intake did not change through the fish-oil supplementation period, but the daily consumption of n-3 fatty acids increased 2.3 times. N-3 fatty supplementation increased EPA and DHA percentages in serum phospholipids, but failed to decrease (p > 0.05) the cholesterol and triglyceride concentration in serum LDL and HDL, although it did so in VLDL. In contrast, the lipoprotein-phospholipid and lipoprotein-protein concentrations were markedly affected, mainly in LDL and HDL (at least p < 0.01). HDL and VLDL compositions were not affected but the total mass (lipid + protein in mg/dl) concentration of these lipoproteins significantly decreased (p < 0.05), suggesting a lower number of these particles in circulating blood after the n-3 treatment. The LDL-cholesterol/LDL-apolipoprotein B ratio increased (p < 0.01) reflecting a probable increase in LDL size. Following fish oil supplementation, LDL particles contained a significantly lower amount of phospholipids, which also suggests changes in the surface/core ratio of the average LDL. Changes in serum lipoprotein lipids did not significantly correlate with any dietary change other than the n-3 fatty acid increase. The results indicate that a 10-day application of a small supplement of n-3 change the LDL composition leading to less atherogenic LDL particles with lower phospholipid and apolipoprotein (Apo) B concentrations.

Authors+Show Affiliations

Departmento de Nutrición y Bromatologia I, Facultad de Farmacia, Universidad Complutense, Madrid, Spain. frasan@eucmax.sim.ucm.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10338684

Citation

Sanchez-Muniz, F J., et al. "Small Supplements of N-3 Fatty Acids Change Serum Low Density Lipoprotein Composition By Decreasing Phospholid and Apolipoprotein B Concentrations in Young Adult Women." European Journal of Nutrition, vol. 38, no. 1, 1999, pp. 20-7.
Sanchez-Muniz FJ, Bastida S, Viejo JM, et al. Small supplements of N-3 fatty acids change serum low density lipoprotein composition by decreasing phospholid and apolipoprotein B concentrations in young adult women. Eur J Nutr. 1999;38(1):20-7.
Sanchez-Muniz, F. J., Bastida, S., Viejo, J. M., & Terpstra, A. H. (1999). Small supplements of N-3 fatty acids change serum low density lipoprotein composition by decreasing phospholid and apolipoprotein B concentrations in young adult women. European Journal of Nutrition, 38(1), 20-7.
Sanchez-Muniz FJ, et al. Small Supplements of N-3 Fatty Acids Change Serum Low Density Lipoprotein Composition By Decreasing Phospholid and Apolipoprotein B Concentrations in Young Adult Women. Eur J Nutr. 1999;38(1):20-7. PubMed PMID: 10338684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small supplements of N-3 fatty acids change serum low density lipoprotein composition by decreasing phospholid and apolipoprotein B concentrations in young adult women. AU - Sanchez-Muniz,F J, AU - Bastida,S, AU - Viejo,J M, AU - Terpstra,A H, PY - 1999/5/25/pubmed PY - 1999/5/25/medline PY - 1999/5/25/entrez SP - 20 EP - 7 JF - European journal of nutrition JO - Eur J Nutr VL - 38 IS - 1 N2 - In order to investigate the effect of a short-term application of marine n-3 polyunsaturated fatty acids on the composition of serum very low density lipoproteins (VLDL), low density lipoproteins (LDL), and high density lipoproteins (HDL), nine women aged 29 +/- 4.2 years, following a diet with a SFA/MUFA/PUFA profile of 2.4/3/1, received supplements of six capsules daily, each capsule containing 0.137 g of n-3 fatty acids (14.5% eicosapentaenoic acid (EPA) and 8.9% docosahexaenoic acid (DHA)) for 10 d. Food consumption, assessed during two 10-days periods indicates that percentage contribution of SFA, MUFA, and PUFA to the daily energy intake did not change through the fish-oil supplementation period, but the daily consumption of n-3 fatty acids increased 2.3 times. N-3 fatty supplementation increased EPA and DHA percentages in serum phospholipids, but failed to decrease (p > 0.05) the cholesterol and triglyceride concentration in serum LDL and HDL, although it did so in VLDL. In contrast, the lipoprotein-phospholipid and lipoprotein-protein concentrations were markedly affected, mainly in LDL and HDL (at least p < 0.01). HDL and VLDL compositions were not affected but the total mass (lipid + protein in mg/dl) concentration of these lipoproteins significantly decreased (p < 0.05), suggesting a lower number of these particles in circulating blood after the n-3 treatment. The LDL-cholesterol/LDL-apolipoprotein B ratio increased (p < 0.01) reflecting a probable increase in LDL size. Following fish oil supplementation, LDL particles contained a significantly lower amount of phospholipids, which also suggests changes in the surface/core ratio of the average LDL. Changes in serum lipoprotein lipids did not significantly correlate with any dietary change other than the n-3 fatty acid increase. The results indicate that a 10-day application of a small supplement of n-3 change the LDL composition leading to less atherogenic LDL particles with lower phospholipid and apolipoprotein (Apo) B concentrations. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/10338684/Small_supplements_of_N_3_fatty_acids_change_serum_low_density_lipoprotein_composition_by_decreasing_phospholid_and_apolipoprotein_B_concentrations_in_young_adult_women_ L2 - https://dx.doi.org/10.1007/s003940050042 DB - PRIME DP - Unbound Medicine ER -