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[Should folic acid be given to women treated with valproic acid and/or carbamazepine? Folic acid and pregnancy in epilepsy].
Rev Neurol (Paris) 1999; 155(3):220-4RN

Abstract

Fetal exposure to valproic acid or carbamazepine increases the risk of neural tube defect (NTD). The risk of a mother having a baby with spina bifida has been estimated at 1-2 p. 100, close to the rate of risk of recurrent cases. No study has evaluated the effect of folic acid in neonates of women treated with valproic acid or carbamazepine although the protective effect against NTD has been proven in other populations. Periconceptional folic acid supplementation, 0.4 to 1 mg/day, for at least one month prior to conception and until the date of the second missed menstrual period or later decreases the incidence of a first occurrence of neural tube defect. Periconceptional folic acid supplementation, 4 mg/day, decreases the recurrence of NTD in women who had previously had a child with NTD. It seems pertinent to recommend periconceptional folic acid supplementation in women treated with carbamazepine or valporic acid. There are very few data in women on which to base a decision to advise taking 4 mg/day (as used in recurrence prevention) or low doses of 0.4 mg/day (used in primary prevention).

Authors+Show Affiliations

Service de Pharmacologie Clinique et Centre Régional de Pharmacovigilance et de Renseignements sur le Médicament du C.H.U. de Tours.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

10339792

Citation

Champel, V, et al. "[Should Folic Acid Be Given to Women Treated With Valproic Acid And/or Carbamazepine? Folic Acid and Pregnancy in Epilepsy]." Revue Neurologique, vol. 155, no. 3, 1999, pp. 220-4.
Champel V, Radal M, Moulin-Vallez M, et al. [Should folic acid be given to women treated with valproic acid and/or carbamazepine? Folic acid and pregnancy in epilepsy]. Rev Neurol (Paris). 1999;155(3):220-4.
Champel, V., Radal, M., Moulin-Vallez, M., Jonville-Béra, A. P., & Autret-Leca, E. (1999). [Should folic acid be given to women treated with valproic acid and/or carbamazepine? Folic acid and pregnancy in epilepsy]. Revue Neurologique, 155(3), pp. 220-4.
Champel V, et al. [Should Folic Acid Be Given to Women Treated With Valproic Acid And/or Carbamazepine? Folic Acid and Pregnancy in Epilepsy]. Rev Neurol (Paris). 1999;155(3):220-4. PubMed PMID: 10339792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Should folic acid be given to women treated with valproic acid and/or carbamazepine? Folic acid and pregnancy in epilepsy]. AU - Champel,V, AU - Radal,M, AU - Moulin-Vallez,M, AU - Jonville-Béra,A P, AU - Autret-Leca,E, PY - 1999/5/26/pubmed PY - 1999/5/26/medline PY - 1999/5/26/entrez SP - 220 EP - 4 JF - Revue neurologique JO - Rev. Neurol. (Paris) VL - 155 IS - 3 N2 - Fetal exposure to valproic acid or carbamazepine increases the risk of neural tube defect (NTD). The risk of a mother having a baby with spina bifida has been estimated at 1-2 p. 100, close to the rate of risk of recurrent cases. No study has evaluated the effect of folic acid in neonates of women treated with valproic acid or carbamazepine although the protective effect against NTD has been proven in other populations. Periconceptional folic acid supplementation, 0.4 to 1 mg/day, for at least one month prior to conception and until the date of the second missed menstrual period or later decreases the incidence of a first occurrence of neural tube defect. Periconceptional folic acid supplementation, 4 mg/day, decreases the recurrence of NTD in women who had previously had a child with NTD. It seems pertinent to recommend periconceptional folic acid supplementation in women treated with carbamazepine or valporic acid. There are very few data in women on which to base a decision to advise taking 4 mg/day (as used in recurrence prevention) or low doses of 0.4 mg/day (used in primary prevention). SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/10339792/[Should_folic_acid_be_given_to_women_treated_with_valproic_acid_and/or_carbamazepine_Folic_acid_and_pregnancy_in_epilepsy]_ L2 - http://www.em-consulte.com/retrieve/pii/MDOI-RN-04-1999-155-3-0035-3787-101019-ART59 DB - PRIME DP - Unbound Medicine ER -