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Lack of influence of test meal fatty acid composition on the contribution of intestinally-derived lipoproteins to postprandial lipaemia.

Abstract

The extent and duration of postprandial lipaemia have been linked to risk of CHD but the influence of dietary variables on, and the relative contributions of, exogenous (chylomicron) and endogenous (VLDL) triacylglycerols to the total lipaemic response have not been comprehensively evaluated. In the present study the triacylglycerol, apolipoprotein (apo) B-48 and retinyl ester (RE) responses to three test meals of varying monounsaturated (MUFA) and saturated fatty acid (SFA) content were measured in the triacylglycerol-rich lipoprotein (TRL) fraction of plasma (rho = 1.006 g/ml) for 9 h after meal consumption. Fifteen healthy normolipidaemic young men consumed, on separate occasions, three test meals which were identical apart from their MUFA and SFA contents. Expressed as a percentage of total energy the MUFA/SFA contents of the meals were: (1) 12%/17%; (2) 17%/12% and (3) 24%/5%. The contribution of the intestinally-derived lipoproteins (chylomicrons) to the lipaemic response was investigated by determining the time to reach peak concentration and the total and incremental areas under the time response curves (AUC and incremental AUC) for RE, apoB-48 and triacylglycerol in the TRL fraction. No significant differences in these measurements were observed for the three meals. However, visual comparison of the postprandial responses to the three meals suggested that as meal MUFA content increased there was a tendency for the triacylglycerol, apoB-48 and RE responses to become biphasic as opposed to the typical monophasic response seen with the 12% MUFA/17% SFA meal. Comparison of the apoB-48 and RE responses for the three test meals confirmed other workers' findings of delayed entry of RE relative to apoB-48 in TRL. The value of the two markers in investigating dietary fat absorption and metabolism is discussed.

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  • Authors+Show Affiliations

    ,

    Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford, UK. k.jackson@afnovell.reading.ac.uk

    , , , , ,

    Source

    The British journal of nutrition 81:1 1999 Jan pg 51-7

    MeSH

    Adult
    Analysis of Variance
    Apolipoprotein B-48
    Apolipoproteins B
    Area Under Curve
    Biomarkers
    Esters
    Fatty Acids
    Fatty Acids, Monounsaturated
    Humans
    Intestinal Mucosa
    Lipids
    Male
    Postprandial Period
    Triglycerides
    Vitamin A

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10341676

    Citation

    Jackson, K G., et al. "Lack of Influence of Test Meal Fatty Acid Composition On the Contribution of Intestinally-derived Lipoproteins to Postprandial Lipaemia." The British Journal of Nutrition, vol. 81, no. 1, 1999, pp. 51-7.
    Jackson KG, Zampelas A, Knapper JM, et al. Lack of influence of test meal fatty acid composition on the contribution of intestinally-derived lipoproteins to postprandial lipaemia. Br J Nutr. 1999;81(1):51-7.
    Jackson, K. G., Zampelas, A., Knapper, J. M., Culverwell, C. C., Wright, J., Gould, B. J., & Williams, C. M. (1999). Lack of influence of test meal fatty acid composition on the contribution of intestinally-derived lipoproteins to postprandial lipaemia. The British Journal of Nutrition, 81(1), pp. 51-7.
    Jackson KG, et al. Lack of Influence of Test Meal Fatty Acid Composition On the Contribution of Intestinally-derived Lipoproteins to Postprandial Lipaemia. Br J Nutr. 1999;81(1):51-7. PubMed PMID: 10341676.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lack of influence of test meal fatty acid composition on the contribution of intestinally-derived lipoproteins to postprandial lipaemia. AU - Jackson,K G, AU - Zampelas,A, AU - Knapper,J M, AU - Culverwell,C C, AU - Wright,J, AU - Gould,B J, AU - Williams,C M, PY - 1999/5/26/pubmed PY - 1999/5/26/medline PY - 1999/5/26/entrez SP - 51 EP - 7 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 81 IS - 1 N2 - The extent and duration of postprandial lipaemia have been linked to risk of CHD but the influence of dietary variables on, and the relative contributions of, exogenous (chylomicron) and endogenous (VLDL) triacylglycerols to the total lipaemic response have not been comprehensively evaluated. In the present study the triacylglycerol, apolipoprotein (apo) B-48 and retinyl ester (RE) responses to three test meals of varying monounsaturated (MUFA) and saturated fatty acid (SFA) content were measured in the triacylglycerol-rich lipoprotein (TRL) fraction of plasma (rho = 1.006 g/ml) for 9 h after meal consumption. Fifteen healthy normolipidaemic young men consumed, on separate occasions, three test meals which were identical apart from their MUFA and SFA contents. Expressed as a percentage of total energy the MUFA/SFA contents of the meals were: (1) 12%/17%; (2) 17%/12% and (3) 24%/5%. The contribution of the intestinally-derived lipoproteins (chylomicrons) to the lipaemic response was investigated by determining the time to reach peak concentration and the total and incremental areas under the time response curves (AUC and incremental AUC) for RE, apoB-48 and triacylglycerol in the TRL fraction. No significant differences in these measurements were observed for the three meals. However, visual comparison of the postprandial responses to the three meals suggested that as meal MUFA content increased there was a tendency for the triacylglycerol, apoB-48 and RE responses to become biphasic as opposed to the typical monophasic response seen with the 12% MUFA/17% SFA meal. Comparison of the apoB-48 and RE responses for the three test meals confirmed other workers' findings of delayed entry of RE relative to apoB-48 in TRL. The value of the two markers in investigating dietary fat absorption and metabolism is discussed. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/10341676/Lack_of_influence_of_test_meal_fatty_acid_composition_on_the_contribution_of_intestinally_derived_lipoproteins_to_postprandial_lipaemia_ L2 - https://www.cambridge.org/core/product/identifier/S0007114599000148/type/journal_article DB - PRIME DP - Unbound Medicine ER -