Tags

Type your tag names separated by a space and hit enter

Breast cancer risk: perception versus reality.

Abstract

Evidence that breast cancer is hormonally mediated has fueled women's concern that use of oral contraceptives (OC) will increase their risk of developing the disease. A recent reanalysis of combined worldwide epidemiologic evidence regarding the relationship between breast cancer risk and use of combination OC provides reassurance that there is little or no association between OC use and breast cancer. Ten or more years after discontinuation of OC use, there is no difference in cumulative risk of breast cancer among OC ever-users and never-users. The risk of breast cancer diagnosis is slightly elevated in current OC users and remains slightly elevated until about 10 years after OC discontinuation. Once recency of use is taken into account, other characteristics have little additional effect. There is no increase in breast cancer risk with increasing dose or duration of OC use and no difference in risk related to type of estrogen or progestin used. Moreover, those breast cancers diagnosed in OC ever-users were found to be significantly more likely to be localized than those diagnosed in same-age never-users.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

    Source

    Contraception 59:1 Suppl 1999 Jan pg 25S-28S

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Breast Neoplasms
    Contraceptives, Oral, Hormonal
    Contraceptives, Oral, Synthetic
    Female
    Humans
    Middle Aged
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    10342093

    Citation

    Westhoff, C L.. "Breast Cancer Risk: Perception Versus Reality." Contraception, vol. 59, no. 1 Suppl, 1999, 25S-28S.
    Westhoff CL. Breast cancer risk: perception versus reality. Contraception. 1999;59(1 Suppl):25S-28S.
    Westhoff, C. L. (1999). Breast cancer risk: perception versus reality. Contraception, 59(1 Suppl), 25S-28S.
    Westhoff CL. Breast Cancer Risk: Perception Versus Reality. Contraception. 1999;59(1 Suppl):25S-28S. PubMed PMID: 10342093.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Breast cancer risk: perception versus reality. A1 - Westhoff,C L, PY - 1999/5/26/pubmed PY - 1999/5/26/medline PY - 1999/5/26/entrez KW - Americas KW - Biology KW - Breast Cancer KW - Cancer KW - Contraception KW - Contraceptive Methods--side effects KW - Developed Countries KW - Diseases KW - Family Planning KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives, Combined--side effects KW - Oral Contraceptives--side effects KW - Risk Factors--women KW - United States KW - Women SP - 25S EP - 28S JF - Contraception JO - Contraception VL - 59 IS - 1 Suppl N2 - Evidence that breast cancer is hormonally mediated has fueled women's concern that use of oral contraceptives (OC) will increase their risk of developing the disease. A recent reanalysis of combined worldwide epidemiologic evidence regarding the relationship between breast cancer risk and use of combination OC provides reassurance that there is little or no association between OC use and breast cancer. Ten or more years after discontinuation of OC use, there is no difference in cumulative risk of breast cancer among OC ever-users and never-users. The risk of breast cancer diagnosis is slightly elevated in current OC users and remains slightly elevated until about 10 years after OC discontinuation. Once recency of use is taken into account, other characteristics have little additional effect. There is no increase in breast cancer risk with increasing dose or duration of OC use and no difference in risk related to type of estrogen or progestin used. Moreover, those breast cancers diagnosed in OC ever-users were found to be significantly more likely to be localized than those diagnosed in same-age never-users. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/10342093/Breast_cancer_risk:_perception_versus_reality_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(98)00134-6 DB - PRIME DP - Unbound Medicine ER -