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Alcohol-histamine interactions.
Alcohol Alcohol 1999 Mar-Apr; 34(2):141-7AA

Abstract

Alcohol and histamine metabolic pathways in the body have the common enzymes aldehyde dehydrogenase and aldehyde oxidase. The metabolite of ethanol, acetaldehyde, can effectively compete with the metabolites of histamine, methylimidazole acetaldehyde, and imidazole acetaldehyde. At the periphery, alcohol and acetaldehyde liberate histamine from its store in mast cells and depress histamine elimination by inhibiting diamine oxidase, resulting in elevated histamine levels in tissues. Histamine mediates alcohol-induced gastric and intestinal damage and bronchial asthma as well as flushing in Orientals. On the other hand, alcohol provokes food-induced histaminosis and histamine intolerance, which is an epidemiological problem. There are many controversial reports concerning the effect of H2 receptor antagonists on ethanol metabolism and the activity of alcohol dehydrogenase in the stomach. In addition, alcohol affects histamine levels in the brain by modulating histamine synthesis, release, and turnover. Histamine receptor antagonists can affect ethanol metabolism and change the sensitivity of animals to the hypnotic effects of alcohol. In contrast to other neurotransmitters, the involvement of the brain histamine system in the mechanisms of the central actions of alcohol and in the pathogenesis of alcoholism is poorly studied and understood.

Authors+Show Affiliations

Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10344773

Citation

Zimatkin, S M., and O V. Anichtchik. "Alcohol-histamine Interactions." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 34, no. 2, 1999, pp. 141-7.
Zimatkin SM, Anichtchik OV. Alcohol-histamine interactions. Alcohol Alcohol. 1999;34(2):141-7.
Zimatkin, S. M., & Anichtchik, O. V. (1999). Alcohol-histamine interactions. Alcohol and Alcoholism (Oxford, Oxfordshire), 34(2), pp. 141-7.
Zimatkin SM, Anichtchik OV. Alcohol-histamine Interactions. Alcohol Alcohol. 1999;34(2):141-7. PubMed PMID: 10344773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol-histamine interactions. AU - Zimatkin,S M, AU - Anichtchik,O V, PY - 1999/5/27/pubmed PY - 1999/5/27/medline PY - 1999/5/27/entrez SP - 141 EP - 7 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol. VL - 34 IS - 2 N2 - Alcohol and histamine metabolic pathways in the body have the common enzymes aldehyde dehydrogenase and aldehyde oxidase. The metabolite of ethanol, acetaldehyde, can effectively compete with the metabolites of histamine, methylimidazole acetaldehyde, and imidazole acetaldehyde. At the periphery, alcohol and acetaldehyde liberate histamine from its store in mast cells and depress histamine elimination by inhibiting diamine oxidase, resulting in elevated histamine levels in tissues. Histamine mediates alcohol-induced gastric and intestinal damage and bronchial asthma as well as flushing in Orientals. On the other hand, alcohol provokes food-induced histaminosis and histamine intolerance, which is an epidemiological problem. There are many controversial reports concerning the effect of H2 receptor antagonists on ethanol metabolism and the activity of alcohol dehydrogenase in the stomach. In addition, alcohol affects histamine levels in the brain by modulating histamine synthesis, release, and turnover. Histamine receptor antagonists can affect ethanol metabolism and change the sensitivity of animals to the hypnotic effects of alcohol. In contrast to other neurotransmitters, the involvement of the brain histamine system in the mechanisms of the central actions of alcohol and in the pathogenesis of alcoholism is poorly studied and understood. SN - 0735-0414 UR - https://www.unboundmedicine.com/medline/citation/10344773/full_citation L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/34.2.141 DB - PRIME DP - Unbound Medicine ER -