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Alcohol-histamine interactions.

Abstract

Alcohol and histamine metabolic pathways in the body have the common enzymes aldehyde dehydrogenase and aldehyde oxidase. The metabolite of ethanol, acetaldehyde, can effectively compete with the metabolites of histamine, methylimidazole acetaldehyde, and imidazole acetaldehyde. At the periphery, alcohol and acetaldehyde liberate histamine from its store in mast cells and depress histamine elimination by inhibiting diamine oxidase, resulting in elevated histamine levels in tissues. Histamine mediates alcohol-induced gastric and intestinal damage and bronchial asthma as well as flushing in Orientals. On the other hand, alcohol provokes food-induced histaminosis and histamine intolerance, which is an epidemiological problem. There are many controversial reports concerning the effect of H2 receptor antagonists on ethanol metabolism and the activity of alcohol dehydrogenase in the stomach. In addition, alcohol affects histamine levels in the brain by modulating histamine synthesis, release, and turnover. Histamine receptor antagonists can affect ethanol metabolism and change the sensitivity of animals to the hypnotic effects of alcohol. In contrast to other neurotransmitters, the involvement of the brain histamine system in the mechanisms of the central actions of alcohol and in the pathogenesis of alcoholism is poorly studied and understood.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno.

    Source

    MeSH

    Alcohol Deterrents
    Animals
    Drug Interactions
    Ethanol
    Ethnic Groups
    Flushing
    Histamine
    Histamine Agonists
    Histamine H1 Antagonists
    Histamine H2 Antagonists
    Humans
    Receptors, Histamine

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    10344773

    Citation

    Zimatkin, S M., and O V. Anichtchik. "Alcohol-histamine Interactions." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 34, no. 2, 1999, pp. 141-7.
    Zimatkin SM, Anichtchik OV. Alcohol-histamine interactions. Alcohol Alcohol. 1999;34(2):141-7.
    Zimatkin, S. M., & Anichtchik, O. V. (1999). Alcohol-histamine interactions. Alcohol and Alcoholism (Oxford, Oxfordshire), 34(2), pp. 141-7.
    Zimatkin SM, Anichtchik OV. Alcohol-histamine Interactions. Alcohol Alcohol. 1999;34(2):141-7. PubMed PMID: 10344773.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol-histamine interactions. AU - Zimatkin,S M, AU - Anichtchik,O V, PY - 1999/5/27/pubmed PY - 1999/5/27/medline PY - 1999/5/27/entrez SP - 141 EP - 7 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol. VL - 34 IS - 2 N2 - Alcohol and histamine metabolic pathways in the body have the common enzymes aldehyde dehydrogenase and aldehyde oxidase. The metabolite of ethanol, acetaldehyde, can effectively compete with the metabolites of histamine, methylimidazole acetaldehyde, and imidazole acetaldehyde. At the periphery, alcohol and acetaldehyde liberate histamine from its store in mast cells and depress histamine elimination by inhibiting diamine oxidase, resulting in elevated histamine levels in tissues. Histamine mediates alcohol-induced gastric and intestinal damage and bronchial asthma as well as flushing in Orientals. On the other hand, alcohol provokes food-induced histaminosis and histamine intolerance, which is an epidemiological problem. There are many controversial reports concerning the effect of H2 receptor antagonists on ethanol metabolism and the activity of alcohol dehydrogenase in the stomach. In addition, alcohol affects histamine levels in the brain by modulating histamine synthesis, release, and turnover. Histamine receptor antagonists can affect ethanol metabolism and change the sensitivity of animals to the hypnotic effects of alcohol. In contrast to other neurotransmitters, the involvement of the brain histamine system in the mechanisms of the central actions of alcohol and in the pathogenesis of alcoholism is poorly studied and understood. SN - 0735-0414 UR - https://www.unboundmedicine.com/medline/citation/10344773/full_citation L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/34.2.141 DB - PRIME DP - Unbound Medicine ER -