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Plasma levels of antioxidant vitamins and cholesterol in a large population sample in central-northern Italy.
Eur J Nutr 1999; 38(2):90-8EJ

Abstract

BACKGROUND

In a population-based multicenter case-control study of diet, life-style, and gastric cancer a large series of adults, aged 30-75 years (mean 58.9 years), were randomly sampled from the general population in 3 areas of Central-Northern Italy.

AIM OF THE STUDY

To evaluate the relationship between plasma levels of antioxidant vitamins and cholesterol, and sociodemographic characteristics, life-style factors, and dietary intake of selected nutrients in a sample of the Italian population.

METHODS

A fasting blood sample was available for 945 subjects (553 men, 392 women). The plasma concentrations of ascorbic acid, carotene, retinol, alpha-tocopherol, and cholesterol were determined by a centralized laboratory. All participants answered to a detailed questionnaire collecting information on sociodemographic and anthropometric characteristics, smoking, alcohol drinking, and dietary habits. Covariance analysis models, with post hoc Dunnett tests, including terms for age, sex, study center, and period of blood drawing, were used for selected multiple-way comparisons of mean values of plasma nutrients.

RESULTS

Mean plasma values of retinol were higher among men while women had higher levels of plasma carotene, ascorbic acid, alpha-tocopherol, and cholesterol. Plasma carotene levels showed an inverse association with body mass index, alcohol consumption, and smoking and a positive association with social class. Carotene concentrations were higher in plasma samples obtained in spring/summer, while ascorbic acid levels were higher in autumn/winter. Partial correlation co-efficients between plasma vitamin levels showed a strong correlation between carotene and ascorbic acid (0.69 in men; 0.74 in women), between carotene and alpha-tocopherol (0.44; 0.37), and between alpha-tocopherol and ascorbic acid (0.45; 0.41). Plasma alpha-tocopherol and retinol correlated with plasma cholesterol. On the other hand, plasma carotene and ascorbic acid were correlated with their estimated dietary intakes, while the intakes of other nutrients, as expected, correlated rather poorly with the respective plasma concentrations.

CONCLUSIONS

Socio-economic factors, life-style, and specific nutrient intake, in addition to gender, are related to nutrient plasma levels in Italian adults and may provide specific suggestions for the prevention of chronic diseases.

Authors+Show Affiliations

Analytical Epidemiology Section, CSPO, A.O. CAREGGI, Florence, Italy. md0632@mclink.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10352948

Citation

Palli, D, et al. "Plasma Levels of Antioxidant Vitamins and Cholesterol in a Large Population Sample in Central-northern Italy." European Journal of Nutrition, vol. 38, no. 2, 1999, pp. 90-8.
Palli D, Decarli A, Russo A, et al. Plasma levels of antioxidant vitamins and cholesterol in a large population sample in central-northern Italy. Eur J Nutr. 1999;38(2):90-8.
Palli, D., Decarli, A., Russo, A., Cipriani, F., Giacosa, A., Amadori, D., ... Buiatti, E. (1999). Plasma levels of antioxidant vitamins and cholesterol in a large population sample in central-northern Italy. European Journal of Nutrition, 38(2), pp. 90-8.
Palli D, et al. Plasma Levels of Antioxidant Vitamins and Cholesterol in a Large Population Sample in Central-northern Italy. Eur J Nutr. 1999;38(2):90-8. PubMed PMID: 10352948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma levels of antioxidant vitamins and cholesterol in a large population sample in central-northern Italy. AU - Palli,D, AU - Decarli,A, AU - Russo,A, AU - Cipriani,F, AU - Giacosa,A, AU - Amadori,D, AU - Salkeld,R, AU - Salvini,S, AU - Buiatti,E, PY - 1999/6/3/pubmed PY - 1999/6/3/medline PY - 1999/6/3/entrez SP - 90 EP - 8 JF - European journal of nutrition JO - Eur J Nutr VL - 38 IS - 2 N2 - BACKGROUND: In a population-based multicenter case-control study of diet, life-style, and gastric cancer a large series of adults, aged 30-75 years (mean 58.9 years), were randomly sampled from the general population in 3 areas of Central-Northern Italy. AIM OF THE STUDY: To evaluate the relationship between plasma levels of antioxidant vitamins and cholesterol, and sociodemographic characteristics, life-style factors, and dietary intake of selected nutrients in a sample of the Italian population. METHODS: A fasting blood sample was available for 945 subjects (553 men, 392 women). The plasma concentrations of ascorbic acid, carotene, retinol, alpha-tocopherol, and cholesterol were determined by a centralized laboratory. All participants answered to a detailed questionnaire collecting information on sociodemographic and anthropometric characteristics, smoking, alcohol drinking, and dietary habits. Covariance analysis models, with post hoc Dunnett tests, including terms for age, sex, study center, and period of blood drawing, were used for selected multiple-way comparisons of mean values of plasma nutrients. RESULTS: Mean plasma values of retinol were higher among men while women had higher levels of plasma carotene, ascorbic acid, alpha-tocopherol, and cholesterol. Plasma carotene levels showed an inverse association with body mass index, alcohol consumption, and smoking and a positive association with social class. Carotene concentrations were higher in plasma samples obtained in spring/summer, while ascorbic acid levels were higher in autumn/winter. Partial correlation co-efficients between plasma vitamin levels showed a strong correlation between carotene and ascorbic acid (0.69 in men; 0.74 in women), between carotene and alpha-tocopherol (0.44; 0.37), and between alpha-tocopherol and ascorbic acid (0.45; 0.41). Plasma alpha-tocopherol and retinol correlated with plasma cholesterol. On the other hand, plasma carotene and ascorbic acid were correlated with their estimated dietary intakes, while the intakes of other nutrients, as expected, correlated rather poorly with the respective plasma concentrations. CONCLUSIONS: Socio-economic factors, life-style, and specific nutrient intake, in addition to gender, are related to nutrient plasma levels in Italian adults and may provide specific suggestions for the prevention of chronic diseases. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/10352948/Plasma_levels_of_antioxidant_vitamins_and_cholesterol_in_a_large_population_sample_in_central_northern_Italy_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -