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Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors.
Psychopharmacology (Berl). 1999 Apr; 143(3):315-7.P

Abstract

RATIONALE

Central cannabinoid systems have been implicated in appetite regulation by the respective hyperphagic actions of exogenous cannabinoids, such as delta9-THC, and hypophagic effects of selective cannabinoid receptor antagonists.

OBJECTIVE

This study examined whether an endogenous cannabinoid, anandamide, could induce overeating, via a specific action at central (CB1) cannabinoid receptors.

METHODS

Pre-satiated male rats (n=18), received subcutaneous injections of anandamide (0.5, 1.0, 5.0, 10.0 mg/kg) before 3-h, nocturnal food intake tests. In a second series of intake tests (n=8), anandamide injection (1.0 mg/kg) was preceded by injection of the specific CB1 receptor antagonist, SR141716 (0.1, 0.5, 1.0 mg/kg SC).

RESULTS

All doses of anandamide induced significant overeating, with 1.0 mg/kg being most potent. Additionally, hyperphagia induced by 1.0 mg/kg anandamide was dose-dependently attenuated by SR141716 pretreatment.

CONCLUSION

This first demonstration of anandamide-induced, CB -mediated, overeating provides important evidence for the involvement of a central cannabinoid system in the normal control of eating.

Authors+Show Affiliations

Department of Psychology, University of Reading, Whiteknights, UK.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10353436

Citation

Williams, C M., and T C. Kirkham. "Anandamide Induces Overeating: Mediation By Central Cannabinoid (CB1) Receptors." Psychopharmacology, vol. 143, no. 3, 1999, pp. 315-7.
Williams CM, Kirkham TC. Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. Psychopharmacology (Berl). 1999;143(3):315-7.
Williams, C. M., & Kirkham, T. C. (1999). Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. Psychopharmacology, 143(3), 315-7.
Williams CM, Kirkham TC. Anandamide Induces Overeating: Mediation By Central Cannabinoid (CB1) Receptors. Psychopharmacology (Berl). 1999;143(3):315-7. PubMed PMID: 10353436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. AU - Williams,C M, AU - Kirkham,T C, PY - 1999/6/3/pubmed PY - 1999/6/3/medline PY - 1999/6/3/entrez SP - 315 EP - 7 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 143 IS - 3 N2 - RATIONALE: Central cannabinoid systems have been implicated in appetite regulation by the respective hyperphagic actions of exogenous cannabinoids, such as delta9-THC, and hypophagic effects of selective cannabinoid receptor antagonists. OBJECTIVE: This study examined whether an endogenous cannabinoid, anandamide, could induce overeating, via a specific action at central (CB1) cannabinoid receptors. METHODS: Pre-satiated male rats (n=18), received subcutaneous injections of anandamide (0.5, 1.0, 5.0, 10.0 mg/kg) before 3-h, nocturnal food intake tests. In a second series of intake tests (n=8), anandamide injection (1.0 mg/kg) was preceded by injection of the specific CB1 receptor antagonist, SR141716 (0.1, 0.5, 1.0 mg/kg SC). RESULTS: All doses of anandamide induced significant overeating, with 1.0 mg/kg being most potent. Additionally, hyperphagia induced by 1.0 mg/kg anandamide was dose-dependently attenuated by SR141716 pretreatment. CONCLUSION: This first demonstration of anandamide-induced, CB -mediated, overeating provides important evidence for the involvement of a central cannabinoid system in the normal control of eating. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/10353436/Anandamide_induces_overeating:_mediation_by_central_cannabinoid__CB1__receptors_ L2 - https://dx.doi.org/10.1007/s002130050953 DB - PRIME DP - Unbound Medicine ER -