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Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity.
J Infect Dis. 1999 Jul; 180(1):122-32.JI

Abstract

To determine the efficacy of a mucosal vaccine against nontypeable Haemophilus influenzae (NTHi), mice were immunized nasally, orally, intratracheally, or intraperitoneally with NTHi antigen together with cholera toxin. Antigen-specific IgA antibody titers in nasal washes and the numbers of antigen-specific IgA-producing cells in nasal passages showed the greatest increases in mice immunized nasally. Cytokine analysis showed that interferon-gamma, interleukin (IL)-2, IL-5, IL-6, and IL-10 were induced by nasal immunization, suggesting that Th2- and Th1-type cells were generated. Furthermore, bacterial clearance of a homologous strain of NTHi from the nasal tract was significantly enhanced in the nasal immunization group. These findings suggest that nasal immunization is an effective vaccination regimen for the induction of antigen-specific mucosal immune responses, which reduce the colonization of NTHi in the nasal tract.

Authors+Show Affiliations

Department of Otolaryngology, Faculty of Medicine, Kagoshima University,Kagoshima 890-8520, Japan. kurono@khosp3.kufm.kagoshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10353870

Citation

Kurono, Y, et al. "Nasal Immunization Induces Haemophilus Influenzae-specific Th1 and Th2 Responses With Mucosal IgA and Systemic IgG Antibodies for Protective Immunity." The Journal of Infectious Diseases, vol. 180, no. 1, 1999, pp. 122-32.
Kurono Y, Yamamoto M, Fujihashi K, et al. Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. J Infect Dis. 1999;180(1):122-32.
Kurono, Y., Yamamoto, M., Fujihashi, K., Kodama, S., Suzuki, M., Mogi, G., McGhee, J. R., & Kiyono, H. (1999). Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. The Journal of Infectious Diseases, 180(1), 122-32.
Kurono Y, et al. Nasal Immunization Induces Haemophilus Influenzae-specific Th1 and Th2 Responses With Mucosal IgA and Systemic IgG Antibodies for Protective Immunity. J Infect Dis. 1999;180(1):122-32. PubMed PMID: 10353870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. AU - Kurono,Y, AU - Yamamoto,M, AU - Fujihashi,K, AU - Kodama,S, AU - Suzuki,M, AU - Mogi,G, AU - McGhee,J R, AU - Kiyono,H, PY - 1999/6/3/pubmed PY - 2000/3/21/medline PY - 1999/6/3/entrez SP - 122 EP - 32 JF - The Journal of infectious diseases JO - J Infect Dis VL - 180 IS - 1 N2 - To determine the efficacy of a mucosal vaccine against nontypeable Haemophilus influenzae (NTHi), mice were immunized nasally, orally, intratracheally, or intraperitoneally with NTHi antigen together with cholera toxin. Antigen-specific IgA antibody titers in nasal washes and the numbers of antigen-specific IgA-producing cells in nasal passages showed the greatest increases in mice immunized nasally. Cytokine analysis showed that interferon-gamma, interleukin (IL)-2, IL-5, IL-6, and IL-10 were induced by nasal immunization, suggesting that Th2- and Th1-type cells were generated. Furthermore, bacterial clearance of a homologous strain of NTHi from the nasal tract was significantly enhanced in the nasal immunization group. These findings suggest that nasal immunization is an effective vaccination regimen for the induction of antigen-specific mucosal immune responses, which reduce the colonization of NTHi in the nasal tract. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10353870/Nasal_immunization_induces_Haemophilus_influenzae_specific_Th1_and_Th2_responses_with_mucosal_IgA_and_systemic_IgG_antibodies_for_protective_immunity_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/314827 DB - PRIME DP - Unbound Medicine ER -