Tags

Type your tag names separated by a space and hit enter

Head and neck mucosal melanoma: a 32-year review.
Ear Nose Throat J. 1999 May; 78(5):372-5.EN

Abstract

Because mucosal melanoma of the head or neck is uncommon, retrospective data are of value in defining its natural history, response to treatment, and patterns of recurrence. We analyzed the medical records of 28 patients who had been treated for a mucosal melanoma of the head or neck between 1961 and 1993. We found that their cumulative 5-year survival rate was 20%. Patients who had primary tumors of the nasal cavity had significantly better 5-year survival than other patients. Early stage at presentation was another predictor of a more favorable outcome. Only 2 of the 17 patients (12%) who underwent surgery died with local disease. However, 13 of these 17 surgical patients (76%) eventually died of distant metastases. There were 3 long-term (> 5 yr) survivors: 2 who were treated by surgery alone, and 1 who was treated with surgery and radiation therapy. We found that aggressive resection of the primary tumor and of any local recurrence can achieve local control in most patients with mucosal melanoma of the head or neck. Distant metastasis is the limiting factor for long-term survival.

Authors+Show Affiliations

Department of Head and Neck Surgery and Oncology, Roswell Park Cancer Institute, Buffalo, N.Y. 14263, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10355199

Citation

Loree, T R., et al. "Head and Neck Mucosal Melanoma: a 32-year Review." Ear, Nose, & Throat Journal, vol. 78, no. 5, 1999, pp. 372-5.
Loree TR, Mullins AP, Spellman J, et al. Head and neck mucosal melanoma: a 32-year review. Ear Nose Throat J. 1999;78(5):372-5.
Loree, T. R., Mullins, A. P., Spellman, J., North, J. H., & Hicks, W. L. (1999). Head and neck mucosal melanoma: a 32-year review. Ear, Nose, & Throat Journal, 78(5), 372-5.
Loree TR, et al. Head and Neck Mucosal Melanoma: a 32-year Review. Ear Nose Throat J. 1999;78(5):372-5. PubMed PMID: 10355199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Head and neck mucosal melanoma: a 32-year review. AU - Loree,T R, AU - Mullins,A P, AU - Spellman,J, AU - North,J H,Jr AU - Hicks,W L,Jr PY - 1999/6/4/pubmed PY - 2001/3/28/medline PY - 1999/6/4/entrez SP - 372 EP - 5 JF - Ear, nose, & throat journal JO - Ear Nose Throat J VL - 78 IS - 5 N2 - Because mucosal melanoma of the head or neck is uncommon, retrospective data are of value in defining its natural history, response to treatment, and patterns of recurrence. We analyzed the medical records of 28 patients who had been treated for a mucosal melanoma of the head or neck between 1961 and 1993. We found that their cumulative 5-year survival rate was 20%. Patients who had primary tumors of the nasal cavity had significantly better 5-year survival than other patients. Early stage at presentation was another predictor of a more favorable outcome. Only 2 of the 17 patients (12%) who underwent surgery died with local disease. However, 13 of these 17 surgical patients (76%) eventually died of distant metastases. There were 3 long-term (> 5 yr) survivors: 2 who were treated by surgery alone, and 1 who was treated with surgery and radiation therapy. We found that aggressive resection of the primary tumor and of any local recurrence can achieve local control in most patients with mucosal melanoma of the head or neck. Distant metastasis is the limiting factor for long-term survival. SN - 0145-5613 UR - https://www.unboundmedicine.com/medline/citation/10355199/Head_and_neck_mucosal_melanoma:_a_32_year_review_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10355199.ui DB - PRIME DP - Unbound Medicine ER -